dbPTM

VDAC2_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VDAC2_RAT
UniProt AC	P81155
Protein Name	Voltage-dependent anion-selective channel protein 2
Gene Name	Vdac2
Organism	Rattus norvegicus (Rat).
Sequence Length	295
Subcellular Localization	Mitochondrion outer membrane.
Protein Description	Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity)..
Protein Sequence	MAECCVPVCQRPICIPPPYADLGKAARDIFNKGFGFGLVKLDVKTKSCSGVEFSTSGSSNTDTGKVSGTLETKYKWCEYGLTFTEKWNTDNTLGTEIAIEDQICQGLKLTFDTTFSPNTGKKSGKIKSAYKRECINLGCDVDFDFAGPAIHGSAVFGYEGWLAGYQMTFDSAKSKLTRSNFAVGYRTGDFQLHTNVNNGTEFGGSIYQKVCEDFDTSVNLAWTSGTNCTRFGIAAKYQLDPTASISAKVNNSSLIGVGYTQTLRPGVKLTLSALVDGKSFNAGGHKLGLALELEA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Succinylation	AARDIFNKGFGFGLV HHHHHHHCCCCCEEE	44.88	-
32	Ubiquitination	AARDIFNKGFGFGLV HHHHHHHCCCCCEEE	44.88	-
32	Acetylation	AARDIFNKGFGFGLV HHHHHHHCCCCCEEE	44.88	18763707
32	Succinylation	AARDIFNKGFGFGLV HHHHHHHCCCCCEEE	44.88	-
40	Acetylation	GFGFGLVKLDVKTKS CCCCEEEEEEECCCC	43.97	22902405
67	Phosphorylation	NTDTGKVSGTLETKY CCCCCEEEEEEECEE	29.55	30181290
67	O-linked_Glycosylation	NTDTGKVSGTLETKY CCCCCEEEEEEECEE	29.55	27213235
69	Phosphorylation	DTGKVSGTLETKYKW CCCEEEEEEECEEEE	17.57	30181290
72	Phosphorylation	KVSGTLETKYKWCEY EEEEEEECEEEEECC	42.67	30181290
73	Acetylation	VSGTLETKYKWCEYG EEEEEECEEEEECCC	35.14	165097
75	Acetylation	GTLETKYKWCEYGLT EEEECEEEEECCCCE	47.10	25786129
79	Phosphorylation	TKYKWCEYGLTFTEK CEEEEECCCCEEEEC	17.82	-
86	Acetylation	YGLTFTEKWNTDNTL CCCEEEECCCCCCCC	42.56	26302492
110	Phosphorylation	ICQGLKLTFDTTFSP HHCCCEEEEEEEECC	20.20	28551015
113	Phosphorylation	GLKLTFDTTFSPNTG CCEEEEEEEECCCCC	26.08	23991683
114	Phosphorylation	LKLTFDTTFSPNTGK CEEEEEEEECCCCCC	24.78	23991683
116	Phosphorylation	LTFDTTFSPNTGKKS EEEEEEECCCCCCCC	18.36	29779826
119	Phosphorylation	DTTFSPNTGKKSGKI EEEECCCCCCCCCCC	54.48	23991683
121	Acetylation	TFSPNTGKKSGKIKS EECCCCCCCCCCCCE	41.55	22902405
177	Phosphorylation	DSAKSKLTRSNFAVG HHHHHHHHCCCEEEE	35.47	23991683
179	Phosphorylation	AKSKLTRSNFAVGYR HHHHHHCCCEEEEEE	30.94	23991683
207	Phosphorylation	TEFGGSIYQKVCEDF CCCCCHHHHHHHCCC	12.18	-
236	Acetylation	TRFGIAAKYQLDPTA CEEEEEEEEECCCCC	25.22	22902405
237	Phosphorylation	RFGIAAKYQLDPTAS EEEEEEEEECCCCCE	15.02	22817900
242	Phosphorylation	AKYQLDPTASISAKV EEEECCCCCEEEEEE	32.48	23984901
244	Phosphorylation	YQLDPTASISAKVNN EECCCCCEEEEEECC	21.39	23984901
246	Phosphorylation	LDPTASISAKVNNSS CCCCCEEEEEECCCC	21.39	23984901
248	Acetylation	PTASISAKVNNSSLI CCCEEEEEECCCCEE	38.41	22902405
252	Phosphorylation	ISAKVNNSSLIGVGY EEEEECCCCEEEECC	22.71	23984901
253	Phosphorylation	SAKVNNSSLIGVGYT EEEECCCCEEEECCC	26.57	23984901
259	Phosphorylation	SSLIGVGYTQTLRPG CCEEEECCCCCCCCC	8.02	23991683
260	Phosphorylation	SLIGVGYTQTLRPGV CEEEECCCCCCCCCC	14.78	23991683
262	Phosphorylation	IGVGYTQTLRPGVKL EEECCCCCCCCCCEE	19.55	23991683
278	Acetylation	LSALVDGKSFNAGGH EEEEECCCCCCCCCC	47.62	22902405
286	Ubiquitination	SFNAGGHKLGLALEL CCCCCCCEEEEEEEE	47.74	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of VDAC2_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of VDAC2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VDAC2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of VDAC2_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VDAC2_RAT

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Post-translational modifications of rat liver mitochondrial outermembrane proteins identified by mass spectrometry."; Distler A.M., Kerner J., Hoppel C.L.; Biochim. Biophys. Acta 1774:628-636(2007). Cited for: PROTEIN SEQUENCE OF 236-243, PHOSPHORYLATION AT TYR-237, AND MASSSPECTROMETRY.	17478130 [Abstract]