GDIB_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GDIB_RAT
• UniProt AC: P50399
• Protein Name: Rab GDP dissociation inhibitor beta
• Gene Name: Gdi2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 445
• Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein.
• Protein Description: Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them..
• Protein Sequence: MNEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDQNPYYGGESASITPLEDLYKRFKLPGQPPASMGRGRDWNVDLIPKFLMANGQLVKMLLFTEVTRYMDFKVIEGSFVYKGGKIYKVPSTEAEALASSLMGLFEKRRFRKFLVYVANFDEKDPRTFEGVDPKKTSMRDVYKKFDLGQDVIDFTGHSLALYRTDDYLDQPCCETINRIKLYSESLARYGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPIEEIIVQNGKVVGVKSEGEIARCKQLICDPSYVKDRVEKVGQVIRVICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISFAHNVAAQGKYIAIVSTTVETKEPEKEIRPALELLEPIEQKFVSISDLFVPKDLGTDSQIFISRAYDATTHFETTCDDIKDIYKRMTGSEFDFEEMKRKKNDIYGED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNEEYDVI -------CCCCCCEE	14.90	-
57	Succinylation	EDLYKRFKLPGQPPA HHHHHHCCCCCCCCC	58.78	-
57	Succinylation	EDLYKRFKLPGQPPA HHHHHHCCCCCCCCC	58.78	-
99	Phosphorylation	LFTEVTRYMDFKVIE HHHCHHHHCCEEEEE	7.53	-
112	Acetylation	IEGSFVYKGGKIYKV EEEEEEEECCEEEEC	56.75	22902405
129	Phosphorylation	TEAEALASSLMGLFE HHHHHHHHHHHHHHH	25.51	22673903
130	Phosphorylation	EAEALASSLMGLFEK HHHHHHHHHHHHHHH	19.44	22673903
142	Acetylation	FEKRRFRKFLVYVAN HHHHCHHHEEEEEEC	40.10	22902405
153	Acetylation	YVANFDEKDPRTFEG EEECCCCCCCCCCCC	74.91	26302492
164	Acetylation	TFEGVDPKKTSMRDV CCCCCCCCCCCHHHH	65.31	22902405
165	Acetylation	FEGVDPKKTSMRDVY CCCCCCCCCCHHHHH	51.74	26302492
174	Acetylation	SMRDVYKKFDLGQDV CHHHHHHHCCCCCCC	26.82	22902405
213	Phosphorylation	INRIKLYSESLARYG HHHHHHHHHHHHHHC	31.01	-
221	Acetylation	ESLARYGKSPYLYPL HHHHHHCCCCCEECC	39.05	66734115
221	Ubiquitination	ESLARYGKSPYLYPL HHHHHHCCCCCEECC	39.05	-
224	Phosphorylation	ARYGKSPYLYPLYGL HHHCCCCCEECCCCC	26.42	-
226	Phosphorylation	YGKSPYLYPLYGLGE HCCCCCEECCCCCCC	5.83	-
229	Phosphorylation	SPYLYPLYGLGELPQ CCCEECCCCCCCCCC	13.05	-
269	Acetylation	NGKVVGVKSEGEIAR CCEEEEECCHHHHHH	36.54	22902405
360	Ubiquitination	VSTTVETKEPEKEIR EEEEECCCCCHHHHH	58.74	-
382	Phosphorylation	PIEQKFVSISDLFVP HHHHHCCCHHHCCCC	21.36	-
418	Succinylation	ETTCDDIKDIYKRMT ECHHHHHHHHHHHHH	45.10	26843850
425	Phosphorylation	KDIYKRMTGSEFDFE HHHHHHHHCCCCCHH	41.40	25575281
427	Phosphorylation	IYKRMTGSEFDFEEM HHHHHHCCCCCHHHH	26.39	28432305

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GDIB_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GDIB_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GDIB_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of GDIB_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.