dbPTM

14331_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	14331_ARATH
UniProt AC	P42643
Protein Name	14-3-3-like protein GF14 chi
Gene Name	GRF1
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	267
Subcellular Localization	Nucleus . Cytoplasm . Translocates from the cytosol to the nucleus when phosphorylated.
Protein Description	Is associated with a DNA binding complex that binds to the G box, a well-characterized cis-acting DNA regulatory element found in plant genes. Involved in the regulation of nutrient metabolism. [PubMed: 22104211]
Protein Sequence	MATPGASSARDEFVYMAKLAEQAERYEEMVEFMEKVAKAVDKDELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEESRGNDDHVSLIRDYRSKIETELSDICDGILKLLDTILVPAAASGDSKVFYLKMKGDYHRYLAEFKSGQERKDAAEHTLTAYKAAQDIANSELAPTHPIRLGLALNFSVFYYEILNSPDRACNLAKQAFDEAIAELDTLGEESYKDSTLIMQLLRDNLTLWTSDMQDDVADDIKEAAPAAAKPADEQQS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATPGASSA ------CCCCCCCCC	23.62	22223895
3	Phosphorylation	-----MATPGASSAR -----CCCCCCCCCH	22.43	30589143
54	Phosphorylation	VEERNLLSVAYKNVI HHHHHHHHHHHHHHH	14.10	25561503
72	Phosphorylation	RASWRIISSIEQKEE HHHHHHHHHHHHHHH	23.92	-
88	Phosphorylation	RGNDDHVSLIRDYRS CCCCCHHHHHHHHHH	18.05	30291188
114	Phosphorylation	GILKLLDTILVPAAA HHHHHHHHHHHHHCC	19.04	19880383
169	Phosphorylation	AAQDIANSELAPTHP HHHHHHHCCCCCCCC	25.60	23111157
195	Phosphorylation	FYYEILNSPDRACNL HHHHHHCCHHHHHHH	25.40	-
216	Phosphorylation	EAIAELDTLGEESYK HHHHHHHCCCCHHHC	49.65	25368622
221	Phosphorylation	LDTLGEESYKDSTLI HHCCCCHHHCCHHHH	32.93	25368622
237	Phosphorylation	QLLRDNLTLWTSDMQ HHHHCCCCCCCCCCC	26.89	23776212
240	Phosphorylation	RDNLTLWTSDMQDDV HCCCCCCCCCCCCHH	20.26	23776212
241	Phosphorylation	DNLTLWTSDMQDDVA CCCCCCCCCCCCHHH	21.36	23776212
267	Phosphorylation	KPADEQQS------- CCHHHHCC-------	41.71	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of 14331_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of 14331_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of 14331_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GIF1_ARATH	AN3	physical	15326298
GLO2_ARATH	AT3G14415	physical	21766784
6PGD1_ARATH	AT1G64190	physical	21766784
AL2C4_ARATH	ALDH2C4	physical	21766784
ACLA2_ARATH	ACLA-2	physical	21766784
ACCC_ARATH	CAC2	physical	21766784
FAP3_ARATH	AT1G53520	physical	21766784
PSL5_ARATH	RSW3	physical	21766784
METE1_ARATH	ATMS1	physical	21766784
CAPP1_ARATH	PPC1	physical	21766784
PGKH1_ARATH	PGK1	physical	21766784
PDX12_ARATH	PDX1.2	physical	21766784
TKTC2_ARATH	AT2G45290	physical	21766784
UGDH3_ARATH	AT5G15490	physical	21766784
UGPA2_ARATH	UGP1	physical	21766784
U78D1_ARATH	UGT78D1	physical	21766784
UXS5_ARATH	UXS5	physical	21766784
CB1A_ARATH	CAB3	physical	21766784
CB1B_ARATH	CAB3	physical	21766784
DML2_ARATH	DML2	physical	21766784
PCNA1_ARATH	PCNA1	physical	21766784
RGP2_ARATH	RGP2	physical	21766784
RS23_ARATH	AT2G41840	physical	21766784
RSSA1_ARATH	P40	physical	21766784
RL121_ARATH	AT2G37190	physical	21766784
RL111_ARATH	RPL16A	physical	21766784
RL301_ARATH	AT1G36240	physical	21766784
R35A2_ARATH	AT1G41880	physical	21766784
RL4A_ARATH	AT3G09630	physical	21766784
EF1G2_ARATH	AT1G57720	physical	21766784
CALR1_ARATH	CRT1a	physical	21766784
CPNB1_ARATH	CPN60B	physical	21766784
HSP7C_ARATH	AT3G09440	physical	21766784
HSP7F_ARATH	cpHsc70-1	physical	21766784
SBT17_ARATH	ARA12	physical	21766784
CD48A_ARATH	CDC48	physical	21766784
ATPBM_ARATH	AT5G08670	physical	21766784
ATPG1_ARATH	ATPC1	physical	21766784
BAS1A_ARATH	AT3G11630	physical	21766784
TCTP1_ARATH	TCTP	physical	21766784
14331_ARATH	GRF1	physical	21766784
14310_ARATH	GRF10	physical	21766784
14337_ARATH	GRF7	physical	21766784
14332_ARATH	GRF2	physical	21766784
14334_ARATH	GF14 PHI	physical	21766784
14333_ARATH	GRF3	physical	21766784
VSP1_ARATH	VSP1	physical	21766784
IDH3_ARATH	IDH-III	physical	22104211
MDHC1_ARATH	AT1G04410	physical	22104211
MDHC2_ARATH	AT5G43330	physical	22104211
SKIP2_ARATH	SKIP2	physical	21094157
SDHA1_ARATH	SDH1-1	physical	21094157
GMD1_ARATH	GMD1	physical	21094157
14338_ARATH	GRF8	physical	21094157
AB10A_ARATH	ATH14	physical	21094157
RL123_ARATH	AT5G60670	physical	21094157
PDX2_ARATH	PDX2	physical	21094157
ETOL2_ARATH	EOL2	physical	21094157
PMA3_ARATH	HA3	physical	21094157
CKX3_ARATH	CKX3	physical	21094157
HATB_ARATH	HAG2	physical	21094157
GPDL4_ARATH	SVL1	physical	21094157
DEF83_ARATH	LCR46	physical	21094157
NFYB2_ARATH	NF-YB2	physical	21094157
ERF80_ARATH	ERF9	physical	21094157
SUC6_ARATH	SUC6	physical	21094157
MDHC2_ARATH	AT5G43330	physical	21094157
MDHC1_ARATH	AT1G04410	physical	21094157
SCPDL_ARATH	AT5G39410	physical	21094157
GLN11_ARATH	GSR 1	physical	21094157
GLN14_ARATH	GLN1;4	physical	21094157
GLN12_ARATH	GSR2	physical	21094157
TYRA1_ARATH	AT5G34930	physical	21094157
LONM1_ARATH	LON1	physical	21094157
RH3_ARATH	emb1138	physical	21094157
2A5K_ARATH	AT5G25510	physical	21094157
SM3L2_ARATH	RAD5	physical	21094157
PER60_ARATH	RHS18	physical	21094157
DCE1_ARATH	GAD	physical	21094157
P2_ARATH	AT5G16990	physical	21094157
BCCP1_ARATH	CAC1	physical	21094157
KIN1_ARATH	KIN1	physical	21094157
VDAC3_ARATH	VDAC3	physical	21094157
CNG18_ARATH	CNGC18	physical	21094157
P5CR1_ARATH	P5CR	physical	21094157
AGP6_ARATH	AGP6	physical	21094157
UTP18_ARATH	AT5G14050	physical	21094157
ATPO_ARATH	ATP5	physical	21094157
PNSL5_ARATH	CYP20-2	physical	21094157
SUT21_ARATH	SULTR2;1	physical	21094157
HEM3_ARATH	HEMC	physical	21094157
FLA17_ARATH	FLA17	physical	21094157
ATE1_ARATH	ATE1	physical	21094157
EIN2_ARATH	EIN2	physical	21094157
MD37E_ARATH	HSC70-1	physical	21094157
CP18C_ARATH	ROC1	physical	21094157
VATB2_ARATH	AT4G38510	physical	21094157
PCKA_ARATH	PCK1	physical	21094157
HA22K_ARATH	HVA22K	physical	21094157
IDH3_ARATH	IDH-III	physical	21094157
MCCB_ARATH	MCCB	physical	21094157
HMA6_ARATH	PAA1	physical	21094157
PMA2_ARATH	HA2	physical	21094157
GH35_ARATH	WES1	physical	21094157
AB2B_ARATH	PGP2	physical	21094157
FWA_ARATH	FWA	physical	21094157
KN14C_ARATH	ATK1	physical	21094157
SNAG_ARATH	GSNAP	physical	21094157
EFTU_ARATH	RABE1b	physical	21094157
MYB98_ARATH	MYB98	physical	21094157
HFA1A_ARATH	HSF1	physical	21094157
CYSK1_ARATH	OASA1	physical	21094157
AMT11_ARATH	AMT1;1	physical	21094157
PLDG2_ARATH	PLDGAMMA2	physical	21094157
SPT16_ARATH	SPT16	physical	21094157
NSF_ARATH	NSF	physical	21094157
METK2_ARATH	SAM-2	physical	21094157
METK4_ARATH	MTO3	physical	21094157
METK3_ARATH	MAT3	physical	21094157
METK1_ARATH	SAM1	physical	21094157
FN3KR_ARATH	AT3G61080	physical	21094157
NT102_ARATH	AT3G57940	physical	21094157
VILI3_ARATH	VLN3	physical	21094157
2A5E_ARATH	AT3G54930	physical	21094157
FIP37_ARATH	FIP37	physical	21094157
PAL2_ARATH	PAL2	physical	21094157
ODP21_ARATH	LTA3	physical	21094157
PP15_ARATH	TOPP5	physical	21094157
R13L2_ARATH	AT3G46710	physical	21094157
IVD_ARATH	IVD	physical	21094157
ACA13_ARATH	AT3G22910	physical	21094157
RH9_ARATH	PMH1	physical	21094157
HAT31_ARATH	HAT3.1	physical	21094157
MSH2_ARATH	MSH2	physical	21094157
MPK9_ARATH	MPK9	physical	21094157
EXP12_ARATH	EXPA12	physical	21094157
CAPP3_ARATH	PPC3	physical	21094157
AB6C_ARATH	MRP8	physical	21094157
MD37C_ARATH	HSP70	physical	21094157
KPK1_ARATH	PK1	physical	21094157
GLR14_ARATH	GLR1.4	physical	21094157
RPM1_ARATH	RPM1	physical	21094157
PRX2F_ARATH	PRXIIF	physical	21094157
SEC_ARATH	SEC	physical	21094157
G3PC1_ARATH	GAPC1	physical	21094157
G3PC2_ARATH	GAPC2	physical	21094157
ATL51_ARATH	AT3G03550	physical	21094157
HAT5_ARATH	HB-1	physical	21094157
TLP3_ARATH	TLP3	physical	21094157
NAC42_ARATH	NAC042	physical	21094157
ATL41_ARATH	AT2G42360	physical	21094157
ACT5_ARATH	AT2G42100	physical	21094157
PI5K5_ARATH	PIP5K5	physical	21094157
AGT22_ARATH	AGT3	physical	21094157
RH21_ARATH	AT2G33730	physical	21094157
RK28_ARATH	AT2G33450	physical	21094157
THIK2_ARATH	PKT3	physical	21094157
SCRK1_ARATH	AT2G31390	physical	21094157
SCRK3_ARATH	AT1G06020	physical	21094157
SCRK2_ARATH	AT1G06030	physical	21094157
RPT2_ARATH	RPT2	physical	21094157
BL1S1_ARATH	AT2G30330	physical	21094157
PUSH_ARATH	AT2G30320	physical	21094157
Y2988_ARATH	AT2G29880	physical	21094157
AB3G_ARATH	AT2G28070	physical	21094157
CNGC6_ARATH	CNGC6	physical	21094157
HAT9_ARATH	HAT9	physical	21094157
CP19B_ARATH	AT2G21130	physical	21094157
PLT4_ARATH	AT2G20780	physical	21094157
SIRK_ARATH	FRK1	physical	21094157
GGPP4_ARATH	GGPS4	physical	21094157
NIR_ARATH	NIR1	physical	21094157
WRKY1_ARATH	ZAP1	physical	21094157
TMM_ARATH	TMM	physical	21094157
HAC1_ARATH	HAC1	physical	21094157
STT7_ARATH	STN7	physical	21094157
1A110_ARATH	ACS10	physical	21094157
DRL13_ARATH	AT1G59780	physical	21094157
MPPA1_ARATH	AT1G51980	physical	21094157
IAA18_ARATH	IAA18	physical	21094157
FBX11_ARATH	AT1G51320	physical	21094157
HXK3_ARATH	HKL1	physical	21094157
BCAT7_ARATH	AT1G50090	physical	21094157
DF124_ARATH	LCR16	physical	21094157
ZIP10_ARATH	ZIP10	physical	21094157
ARFF_ARATH	ARF6	physical	21094157
GRXC9_ARATH	GRX480	physical	21094157
AB13B_ARATH	PGP13	physical	21094157
14312_ARATH	GRF12	physical	21094157
SUT13_ARATH	SULTR1;3	physical	21094157
WOX14_ARATH	WOX14	physical	21094157
XXT4_ARATH	AT1G18690	physical	21094157
CH10_ARATH	CPN10	physical	21094157
PIF3_ARATH	PIF3	physical	21094157
PORC_ARATH	POR C	physical	21094157
CNX3_ARATH	CNX3	physical	21094157
RIBA1_ARATH	GCH	physical	21094157
ATL31_ARATH	CNI1	physical	21094157
EMS1_ARATH	EMS1	physical	21094157
SAT4_ARATH	SERAT3;2	physical	21094157
SWI3D_ARATH	CHB3	physical	21094157
AB41G_ARATH	PDR13	physical	21094157
IAA19_ARATH	IAA19	physical	21094157
AB26G_ARATH	WBC27	physical	21094157
14334_ARATH	GF14 PHI	physical	21094157
TLP10_ARATH	TLP10	physical	21094157

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of 14331_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks."; Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.; Plant Physiol. 150:889-903(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-267, AND MASSSPECTROMETRY.	19376835 [Abstract]
"Site-specific phosphorylation profiling of Arabidopsis proteins bymass spectrometry and peptide chip analysis."; de la Fuente van Bentem S., Anrather D., Dohnal I., Roitinger E.,Csaszar E., Joore J., Buijnink J., Carreri A., Forzani C.,Lorkovic Z.J., Barta A., Lecourieux D., Verhounig A., Jonak C.,Hirt H.; J. Proteome Res. 7:2458-2470(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-267, AND MASSSPECTROMETRY.	18433157 [Abstract]