TKTC2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TKTC2_ARATH
• UniProt AC: F4IW47
• Protein Name: Transketolase-2, chloroplastic
• Gene Name: TKL-2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 741
• Subcellular Localization: Plastid, chloroplast thylakoid membrane. Plastid, chloroplast stroma .
• Protein Description: Catalyzes the reversible transfer of a two-carbon ketol group from fructose-6-phosphate or sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate to yield xylulose-5-phosphate and erythrose-4-phosphate or ribose-5-phosphate, respectively (By similarity). Could act as a stress sensor involved in adaptation process..
• Protein Sequence: MASTSSLALSQALLTRAISHNGSENCVSIPAFSALKSTSPRTSGTISSRRRNASTISHSLRPLVRAAAVEAIVTSSDSSLVDKSVNTIRFLAIDAVEKAKSGHPGLPMGCAPMSHILYDEVMKYNPKNPYWFNRDRFVLSAGHGCMLQYALLHLAGYDSVREEDLKSFRQWGSKTPGHPENFETPGVEATTGPLGQGIANAVGLALAEKHLAARFNKPDNEIVDHYTYSILGDGCQMEGISNEVCSLAGHWGLGKLIAFYDDNHISIDGDTDIAFTESVDKRFEALGWHVIWVKNGNNGYDEIRAAIREAKAVTDKPTLIKVTTTIGYGSPNKANSYSVHGAALGEKEVEATRNNLGWPYEPFHVPEDVKSHWSRHTPEGAALEADWNAKFAAYEKKYPEEAAELKSIISGELPVGWEKALPTYTPDSPGDATRNLSQQCLNALAKAVPGFLGGSADLASSNMTMLKAFGNFQKATPEERNLRFGVREHGMGAICNGIALHSPGFIPYCATFFVFTDYMRAAMRISALSEAGVIYVMTHDSIGLGEDGPTHQPIEHLSSFRAMPNIMMFRPADGNETAGAYKIAVTKRKTPSVLALSRQKLPQLPGTSIESVEKGGYTISDNSTGNKPDVILIGTGSELEIAAQAAEKLREQGKSVRVVSFVCWELFDEQSDAYKESVLPSDVSARVSIEAGSTFGWGKIVGGKGKSIGIDTFGASAPAGKLYKEFGITIEAMVEAAKSLI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Phosphorylation	RRNASTISHSLRPLV CCCHHHHCHHHHHHH		25368622
59	Phosphorylation	NASTISHSLRPLVRA CHHHHCHHHHHHHHH		25368622
66	Acetylation	SLRPLVRAAAVEAIV HHHHHHHHHHHHHHH		22223895
336	Phosphorylation	GSPNKANSYSVHGAA CCCCCCCCEEECCCC		22092075
338	Phosphorylation	PNKANSYSVHGAALG CCCCCCEEECCCCCC		25561503
398	Phosphorylation	FAAYEKKYPEEAAEL HHHHHHHCHHHHHHH		19880383
428	Phosphorylation	LPTYTPDSPGDATRN CCCCCCCCCCHHHHH		19880383
437	Phosphorylation	GDATRNLSQQCLNAL CHHHHHHHHHHHHHH		30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TKTC2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TKTC2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TKTC2_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of TKTC2_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.