dbPTM

CD48A_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CD48A_ARATH
UniProt AC	P54609
Protein Name	Cell division control protein 48 homolog A
Gene Name	CDC48A
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	809
Subcellular Localization	Nucleus. Cytoplasm, cytoskeleton, phragmoplast. Cell membrane Peripheral membrane protein. Primarily localized to the nucleus and, during cytokinesis, to the phragmoplast, a site where membrane vesicles are targeted in the deposition of new cell wal
Protein Description	Probably functions in cell division and growth processes. Interacts with certain SNAREs as part of specialized membrane fusion events where vesicles from the same organelle fuse (homotypic fusion) (By similarity)..
Protein Sequence	MSTPAESSDSKSKKDFSTAILERKKSPNRLVVDEAINDDNSVVSLHPATMEKLQLFRGDTILIKGKKRKDTVCIALADETCEEPKIRMNKVVRSNLRVRLGDVISVHQCPDVKYGKRVHILPVDDTVEGVTGNLFDAYLKPYFLEAYRPVRKGDLFLVRGGMRSVEFKVIETDPAEYCVVAPDTEIFCEGEPVKREDEERLDDVGYDDVGGVRKQMAQIRELVELPLRHPQLFKSIGVKPPKGILLYGPPGSGKTLIARAVANETGAFFFCINGPEIMSKLAGESESNLRKAFEEAEKNAPSIIFIDEIDSIAPKREKTNGEVERRIVSQLLTLMDGLKSRAHVIVMGATNRPNSIDPALRRFGRFDREIDIGVPDEIGRLEVLRIHTKNMKLAEDVDLERISKDTHGYVGADLAALCTEAALQCIREKMDVIDLEDDSIDAEILNSMAVTNEHFHTALGNSNPSALRETVVEVPNVSWNDIGGLENVKRELQETVQYPVEHPEKFEKFGMSPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVREIFDKARQSAPCVLFFDELDSIATQRGGGSGGDGGGAADRVLNQLLTEMDGMNAKKTVFIIGATNRPDIIDSALLRPGRLDQLIYIPLPDEDSRLNIFKAALRKSPIAKDVDIGALAKYTQGFSGADITEICQRACKYAIRENIEKDIEKEKRRSENPEAMEEDGVDEVSEIKAAHFEESMKYARRSVSDADIRKYQAFAQTLQQSRGFGSEFRFENSAGSGATTGVADPFATSAAAAGDDDDLYN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSTPAESSD ------CCCCCCCCC	43.00	22223895
2	Phosphorylation	------MSTPAESSD ------CCCCCCCCC	43.00	25561503
3	Phosphorylation	-----MSTPAESSDS -----CCCCCCCCCC	25.81	25561503
7	Phosphorylation	-MSTPAESSDSKSKK -CCCCCCCCCCCCHH	41.36	25561503
8	Phosphorylation	MSTPAESSDSKSKKD CCCCCCCCCCCCHHH	37.09	25561503
10	Phosphorylation	TPAESSDSKSKKDFS CCCCCCCCCCHHHHH	40.55	25561503
17	Phosphorylation	SKSKKDFSTAILERK CCCHHHHHHHHHHCC	27.36	19880383
18	Phosphorylation	KSKKDFSTAILERKK CCHHHHHHHHHHCCC	20.08	27531888
41	Phosphorylation	EAINDDNSVVSLHPA ECCCCCCCEEEECHH	30.78	17693538
50	Sulfoxidation	VSLHPATMEKLQLFR EEECHHHHHHHHHHC	4.67	23289948
109	S-nitrosylation	DVISVHQCPDVKYGK CEEEEEECCCCCCCC	1.55	22115780
512	Phosphorylation	KFEKFGMSPSKGVLF HHHHCCCCCCCCEEE	26.80	19880383
724	Sulfoxidation	RSENPEAMEEDGVDE HCCCHHHHHHCCCCH	5.74	23289948
744	Sulfoxidation	AAHFEESMKYARRSV HHHHHHHHHHHHHCC	4.32	25693801
750	Phosphorylation	SMKYARRSVSDADIR HHHHHHHCCCHHHHH	22.03	25561503
752	Phosphorylation	KYARRSVSDADIRKY HHHHHCCCHHHHHHH	28.47	29654922
774	Phosphorylation	QQSRGFGSEFRFENS HHHCCCCCCEEEECC	31.16	29654922
781	Phosphorylation	SEFRFENSAGSGATT CCEEEECCCCCCCCC	27.15	22631563
784	Phosphorylation	RFENSAGSGATTGVA EEECCCCCCCCCCCC	25.60	22631563

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CD48A_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
41	S	Phosphorylation		17693538
Phosphorylated on at least one threonine residue and on Ser-41 by SERK1.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CD48A_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SERK1_ARATH	SERK1	physical	16621602
SERK1_ARATH	SERK1	physical	15592873
CD48A_ARATH	CDC48	physical	15592873

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CD48A_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"In vivo hexamerization and characterization of the Arabidopsis AAAATPase CDC48A complex using forster resonance energy transfer-fluorescence lifetime imaging microscopy and fluorescence correlationspectroscopy."; Aker J., Hesselink R., Engel R., Karlova R., Borst J.W.,Visser A.J.W.G., de Vries S.C.; Plant Physiol. 145:339-350(2007). Cited for: SUBUNIT, INTERACTION WITH SERK1, AND PHOSPHORYLATION AT SER-41.	17693538 [Abstract]

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