RH21_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RH21_ARATH
• UniProt AC: P93008
• Protein Name: DEAD-box ATP-dependent RNA helicase 21
• Gene Name: RH21
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 733
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity)..
• Protein Sequence: MKRTINEVVGSTSVNTLDSSIAKKPVFLTKKQREELALKRRQDQISEQRVRREQLGRPEPETEDVSNGDTNRDKDRDRDRDRDRERDRDRERDRGRDRDRDRDRDRDRDRERERDRERDRRERDREPDRRNREKEREEEVKAREKARVEKLVEREKEKELDAIKEQYLGGKKPKKRVIRPSEKFRFSFDWENTEDTSRDMNVLYQNPHEAQLLFGRGFRAGMDRREQKKQAAKHEKEMRDEIRKKDGIVEKPEEAAAQRVREEAADTYDSFDMRVDRHWSDKRLEEMTERDWRIFREDFNISYKGSRIPRPMRSWEESKLTSELLKAVERAGYKKPSPIQMAAIPLGLQQRDVIGIAETGSGKTAAFVLPMLAYISRLPPMSEENETEGPYAVVMAPTRELAQQIEEETVKFAHYLGFRVTSIVGGQSIEEQGLKITQGCEIVIATPGRLIDCLERRYAVLNQCNYVVLDEADRMIDMGFEPQVAGVLDAMPSSNLKPENEEEELDEKKIYRTTYMFSATMPPGVERLARKYLRNPVVVTIGTAGKTTDLISQHVIMMKESEKFFRLQKLLDELGEKTAIVFVNTKKNCDSIAKNLDKAGYRVTTLHGGKSQEQREISLEGFRAKRYNVLVATDVVGRGIDIPDVAHVINYDMPKHIEMYTHRIGRTGRAGKSGVATSFLTLHDTEVFYDLKQMLVQSNSAVPPELARHEASRFKPGTVPDRPPRHSDTVYIN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	Phosphorylation	LGRPEPETEDVSNGD HCCCCCCCCCCCCCC	48.47	30407730
66	Phosphorylation	EPETEDVSNGDTNRD CCCCCCCCCCCCCCC	47.63	30407730
685	Phosphorylation	SFLTLHDTEVFYDLK EEEEECCHHHHHCHH	24.25	25368622
689	Phosphorylation	LHDTEVFYDLKQMLV ECCHHHHHCHHHHHH	26.07	25368622
698	Phosphorylation	LKQMLVQSNSAVPPE HHHHHHHCCCCCCHH	25.85	25368622
700	Phosphorylation	QMLVQSNSAVPPELA HHHHHCCCCCCHHHH	35.57	25368622

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RH21_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RH21_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RH21_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of RH21_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.