TMM_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMM_ARATH
• UniProt AC: Q9SSD1
• Protein Name: Protein TOO MANY MOUTHS {ECO:0000303|PubMed:11536724}
• Gene Name: TMM {ECO:0000303|PubMed:11536724}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 496
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Promotes cell fate progression in stomatal development. In leaves, needed to correctly orient spacing divisions, to limit the number of asymmetric divisions in neighbor cells, and to promote the asymmetric (amplifying) divisions of meristemoids. In stems, promotes the conversion of meristemoids into guard mother cells (GMC). [PubMed: 11090210]
• Protein Sequence: MARYEFFRQIFIVLSIVSPLVRSFTVITSDSTAPSALIDGPQTGFTMTNDGARTEPDEQDAVYDIMRATGNDWAAAIPDVCRGRWHGIECMPDQDNVYHVVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSKSGSTVRLCDAETSRPAPSGTVQHLSREEDGALPDGATDVSSTSKSLGFSYLSAFFLVFPNFIFMLISS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
181	N-linked_Glycosylation	PIPDELGNLTNLKVL CCCHHHCCCCCCEEE	57.21	-
196	N-linked_Glycosylation	DLHKNHLNGSIPLSF ECHHCCCCCCCCCCC	34.32	-
286	Phosphorylation	LVLLDLSYNRLSGPF HHHHCCCCCCCCCCC	16.17	24894044
362	N-linked_Glycosylation	VLHLEGNNLTGEIPL EEEEECCCCCCCCCC	50.24	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMM_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMM_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMM_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EPF2_ARATH	EPF2	physical	22241782
ERECT_ARATH	ER	physical	22241782
ERL1_ARATH	ERL1	physical	22241782

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.