ERECT_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ERECT_ARATH
• UniProt AC: Q42371
• Protein Name: LRR receptor-like serine/threonine-protein kinase ERECTA {ECO:0000303|PubMed:8624444}
• Gene Name: ERECTA {ECO:0000303|PubMed:8624444}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 976
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Receptor kinase that, together with ERL1 and ERL2, regulates aerial architecture, including inflorescence (e.g. shoot apical meristem-originating organ shape, elongation of the internode and pedicels, and adaxial-abaxial polarity), and stomatal patterning (e.g. density and clustering), probably by tuning cell division and expansion. Redundantly involved with ERL1 in procambial development regulation. Forms a functional ligand-receptor pair with EPF2 (AC Q8LC53). [PubMed: 22241782 Modulates plant transpiration efficiency by controlling stomatal density, leaf photosynthetic capacity, epidermal cell expansion, mesophyll cell proliferation and cell-cell contact. A phloem-specific expression of ER is sufficient for proper inflorescence architecture]
• Protein Sequence: MALFRDIVLLGFLFCLSLVATVTSEEGATLLEIKKSFKDVNNVLYDWTTSPSSDYCVWRGVSCENVTFNVVALNLSDLNLDGEISPAIGDLKSLLSIDLRGNRLSGQIPDEIGDCSSLQNLDLSFNELSGDIPFSISKLKQLEQLILKNNQLIGPIPSTLSQIPNLKILDLAQNKLSGEIPRLIYWNEVLQYLGLRGNNLVGNISPDLCQLTGLWYFDVRNNSLTGSIPETIGNCTAFQVLDLSYNQLTGEIPFDIGFLQVATLSLQGNQLSGKIPSVIGLMQALAVLDLSGNLLSGSIPPILGNLTFTEKLYLHSNKLTGSIPPELGNMSKLHYLELNDNHLTGHIPPELGKLTDLFDLNVANNDLEGPIPDHLSSCTNLNSLNVHGNKFSGTIPRAFQKLESMTYLNLSSNNIKGPIPVELSRIGNLDTLDLSNNKINGIIPSSLGDLEHLLKMNLSRNHITGVVPGDFGNLRSIMEIDLSNNDISGPIPEELNQLQNIILLRLENNNLTGNVGSLANCLSLTVLNVSHNNLVGDIPKNNNFSRFSPDSFIGNPGLCGSWLNSPCHDSRRTVRVSISRAAILGIAIGGLVILLMVLIAACRPHNPPPFLDGSLDKPVTYSTPKLVILHMNMALHVYEDIMRMTENLSEKYIIGHGASSTVYKCVLKNCKPVAIKRLYSHNPQSMKQFETELEMLSSIKHRNLVSLQAYSLSHLGSLLFYDYLENGSLWDLLHGPTKKKTLDWDTRLKIAYGAAQGLAYLHHDCSPRIIHRDVKSSNILLDKDLEARLTDFGIAKSLCVSKSHTSTYVMGTIGYIDPEYARTSRLTEKSDVYSYGIVLLELLTRRKAVDDESNLHHLIMSKTGNNEVMEMADPDITSTCKDLGVVKKVFQLALLCTKRQPNDRPTMHQVTRVLGSFMLSEQPPAATDTSATLAGSCYVDEYANLKTPHSVNCSSMSASDAQLFLRFGQVISQNSE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
65	N-linked_Glycosylation	WRGVSCENVTFNVVA EECCCCCCEEEEEEE	42.32	-
74	N-linked_Glycosylation	TFNVVALNLSDLNLD EEEEEEEEHHHCCCC	27.97	-
221	N-linked_Glycosylation	LWYFDVRNNSLTGSI CEEEEECCCCCCCCC	42.14	-
234	N-linked_Glycosylation	SIPETIGNCTAFQVL CCCCCCCCCCEEEEE	19.00	-
305	N-linked_Glycosylation	SIPPILGNLTFTEKL CCCCCCCCCCCCEEE	32.25	-
329	N-linked_Glycosylation	SIPPELGNMSKLHYL CCCHHHCCCCCCEEE	44.15	-
409	N-linked_Glycosylation	LESMTYLNLSSNNIK HHHCCEEECCCCCCC	27.71	-
457	N-linked_Glycosylation	LEHLLKMNLSRNHIT HHHHHHCCCCCCCCC	33.02	-
510	N-linked_Glycosylation	LLRLENNNLTGNVGS EEEECCCCCCCCHHH	51.03	-
528	N-linked_Glycosylation	CLSLTVLNVSHNNLV HHHEEEEECCCCCCC	28.98	-
543	N-linked_Glycosylation	GDIPKNNNFSRFSPD CCCCCCCCCCCCCCC	45.74	-
645	Phosphorylation	YEDIMRMTENLSEKY HHHHHHHHCCCCCCE	16.03	-
721	Phosphorylation	HLGSLLFYDYLENGS HHHHHHHHHHHHCCC	12.03	-
760	Phosphorylation	GAAQGLAYLHHDCSP HHHHHHHHHCCCCCC	16.18	-
815	Phosphorylation	YVMGTIGYIDPEYAR EEEEEEEECCHHHHC	9.78	-
823	Phosphorylation	IDPEYARTSRLTEKS CCHHHHCCCCCCCCC	15.27	-
972	Phosphorylation	LRFGQVISQNSE--- HHHHHHHCCCCC---	25.18	25561503
975	Phosphorylation	GQVISQNSE------ HHHHCCCCC------	0.00	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ERECT_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ERECT_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ERECT_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EPF1_ARATH	EPF1	physical	22241782
EPF2_ARATH	EPF2	physical	22241782
ERECT_ARATH	ER	physical	22241782
ERL1_ARATH	ERL1	physical	22241782
MSBP1_ARATH	MSBP1	physical	24833385
HHP2_ARATH	HHP2	physical	24833385
UBC34_ARATH	UBC34	physical	24833385
POT2_ARATH	KT2	physical	24833385
BET12_ARATH	ATBET12	physical	24833385
ERECT_ARATH	ER	physical	25969537

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.