dbPTM

POT2_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	POT2_ARATH
UniProt AC	O22881
Protein Name	Potassium transporter 2
Gene Name	POT2
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	794
Subcellular Localization	Cell membrane Multi-pass membrane protein .
Protein Description	Low-affinity potassium transporter. Could mediate the potassium-dependent cell expansion in growing tissues..
Protein Sequence	MDLNLGKCCGSRSSKKESWRSVLLLAYQSLGVVYGDLSISPLYVFKSTFAEDIQHSETNEEIYGVMSFVFWTLTLVPLLKYVFIVLRADDNGEGGTFALYSLICRHVKVSLLPNRQVSDEALSTYKLEHPPEKNHDSCVKRYLEKHKWLHTALLLLVLLGTCMVIGDGLLTPAISVFSAVSGLELNMSKEHHQYAVIPITCFILVCLFSLQHFGTHRVGFVFAPIVLTWLLCISGIGLYNIIQWNPHIYKALSPTYMFMFLRKTRVSGWMSLGGILLCITGAEAMFADLGHFNYAAIQIAFTFLVYPALILAYMGQAAYLSRHHHSAHAIGFYVSVPKCLHWPVLAVAILASVVGSQAIISGTFSIINQSQSLGCFPRVKVIHTSDKMHGQIYIPEINWMLMILCIAVTIGFRDVKHLGNASGLAVMAVMLVTTCLTSLVIVLCWHKPPILALAFLLFFGSIELLYFSASLTKFREGAWLPILLSLIFMIIMFVWHYTTIKKYEFDLQNKVSLEWLLALGPSLGISRVPGIGLVFTDLTSGIPANFSRFVTNLPAFHRVLVFVCVKSVPVPFVPPAERYLVGRVGPVDHRSYRCIVRYGYRDVHQDVDSFETELVSKLADFIRYDWHKRTQQEDDNARSVQSNESSSESRLAVIGTVAYEIEDNLQPESVSIGFSTVESMEDVIQMAEPAPTATIRRVRFAVEENSYEDEGSTSSAEADAELRSELRDLLAAQEAGTAFILGHSHVKAKQGSSVMKRLAVNFGYNFLRRNCRGPDVALKVPPVSLLEVGMVYVV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
639	Phosphorylation	QEDDNARSVQSNESS CCCCCCCCHHCCCCC	23.30	15308754
642	Phosphorylation	DNARSVQSNESSSES CCCCCHHCCCCCHHH	40.17	15308754
645	Phosphorylation	RSVQSNESSSESRLA CCHHCCCCCHHHHHH	43.33	15308754
646	Phosphorylation	SVQSNESSSESRLAV CHHCCCCCHHHHHHH	31.76	25561503
647	Phosphorylation	VQSNESSSESRLAVI HHCCCCCHHHHHHHE	49.20	25561503
649	Phosphorylation	SNESSSESRLAVIGT CCCCCHHHHHHHEEE	34.24	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of POT2_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of POT2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of POT2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
UBC34_ARATH	UBC34	physical	24833385
CNIH1_ARATH	AT3G12180	physical	24833385

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of POT2_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteomics of the Arabidopsis plasma membrane and a newphosphorylation site database."; Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.; Plant Cell 16:2394-2405(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639; SER-642 ANDSER-645, AND MASS SPECTROMETRY.	15308754 [Abstract]
"Large-scale analysis of in vivo phosphorylated membrane proteins byimmobilized metal ion affinity chromatography and mass spectrometry."; Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.; Mol. Cell. Proteomics 2:1234-1243(2003). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639; SER-642 ANDSER-645, AND MASS SPECTROMETRY.	14506206 [Abstract]