HEM3_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HEM3_ARATH
• UniProt AC: Q43316
• Protein Name: Porphobilinogen deaminase, chloroplastic
• Gene Name: HEMC
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 382
• Subcellular Localization: Plastid, chloroplast.
• Protein Description: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps..
• Protein Sequence: MDIASSSLSQAHKVVLTRQPSSRVNTCSLGSVSAIGFSLPQISSPALGKCRRKQSSSGFVKACVAVEQKTRTAIIRIGTRGSPLALAQAYETREKLKKKHPELVEDGAIHIEIIKTTGDKILSQPLADIGGKGLFTKEIDEALINGHIDIAVHSMKDVPTYLPEKTILPCNLPREDVRDAFICLTAATLAELPAGSVVGTASLRRKSQILHKYPALHVEENFRGNVQTRLSKLQGGKVQATLLALAGLKRLSMTENVASILSLDEMLPAVAQGAIGIACRTDDDKMATYLASLNHEETRLAISCERAFLETLDGSCRTPIAGYASKDEEGNCIFRGLVASPDGTKVLETSRKGPYVYEDMVKMGKDAGQELLSRAGPGFFGN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
82	Phosphorylation	IRIGTRGSPLALAQA EEECCCCCHHHHHHH	17.28	25561503
123	Phosphorylation	TTGDKILSQPLADIG CCCCHHHCCCHHHCC	32.97	30291188
315	Phosphorylation	FLETLDGSCRTPIAG HHHHCCCCCCCCCCC	10.49	19880383
316	S-(dipyrrolylmethanemethyl)cysteine	LETLDGSCRTPIAGY HHHCCCCCCCCCCCC	7.40	-
316	Pyrrolylation	LETLDGSCRTPIAGY HHHCCCCCCCCCCCC	7.40	23519422
340	Phosphorylation	IFRGLVASPDGTKVL EEEEEEECCCCCEEE	18.95	25561503
360	Sulfoxidation	GPYVYEDMVKMGKDA CCCCHHHHHHCCHHH	1.77	25693801
373	Phosphorylation	DAGQELLSRAGPGFF HHHHHHHHHHCCCCC	32.48	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HEM3_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HEM3_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HEM3_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of HEM3_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-123, AND MASSSPECTROMETRY.
PubMed: 19376835