FIP37_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FIP37_ARATH
• UniProt AC: Q9ZSZ8
• Protein Name: FKBP12-interacting protein of 37 kDa
• Gene Name: FIP37
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 330
• Subcellular Localization: Nucleus speckle . Nuclear with a speckled distribution pattern.
• Protein Description: Probable regulatory subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing and processing and mRNA stability (By similarity). Essential protein required during endosperm development and embryogenesis. Involved in endoreduplication, especially in trichomes. May play a role in splicing events..
• Protein Sequence: MEFSSQDDDFGGDDSAANATRASGNRRSFGDLEDDEDDIFGSTTVAPGVRTGMILSLRGSLKNCKDDLASCQNELESAKTEIQKWKSAFQNESFVPAGKSPEPRFLIDYIQNLKSSEKSLKEQLEIAKRKEASCIVQYAKREQEMAELKSAVRDLKSQLKPASMQARRLLLDPAIHEEFSRLKNLVEEKDKKIKELQDNIAAVTFTPQSKNGKMLMAKCRTLQEENEEIGHQAAEGKIHELAIKLAMQKSQNAELRSQFEGLYKHMEELTNDVERSNETVIILQEKLEEKEKEIERVKKGLEIVSELVGDKKDEVDEIDEDAKEEIAGGE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEFSSQDD -------CCCCCCCC	12.08	22223895
4	Phosphorylation	----MEFSSQDDDFG ----CCCCCCCCCCC	17.49	19880383
5	Phosphorylation	---MEFSSQDDDFGG ---CCCCCCCCCCCC	42.84	19880383
15	Phosphorylation	DDFGGDDSAANATRA CCCCCCCHHHHHHHC	33.74	24894044
20	Phosphorylation	DDSAANATRASGNRR CCHHHHHHHCCCCCC	26.95	24894044
23	Phosphorylation	AANATRASGNRRSFG HHHHHHCCCCCCCCC	33.05	24894044
28	Phosphorylation	RASGNRRSFGDLEDD HCCCCCCCCCCCCCC	30.28	30291188
87	Phosphorylation	TEIQKWKSAFQNESF HHHHHHHHHHCCCCC	32.95	23776212
93	Phosphorylation	KSAFQNESFVPAGKS HHHHCCCCCCCCCCC	38.81	23776212
100	Phosphorylation	SFVPAGKSPEPRFLI CCCCCCCCCCCHHHH	33.31	30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FIP37_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FIP37_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FIP37_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FIP37_ARATH	FIP37	physical	21798944
KIWI_ARATH	KIWI	physical	21798944

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.