KIWI_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KIWI_ARATH
• UniProt AC: O65154
• Protein Name: RNA polymerase II transcriptional coactivator KIWI
• Gene Name: KIWI
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 107
• Subcellular Localization: Nucleus.
• Protein Description: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. Binds single-stranded DNA (By similarity)..
• Protein Sequence: MSSRGKRKDEDVRASDDESETHAPAKKVAKPADDSDQSDDIVVCNISKNRRVSVRNWNGKIWIDIREFYVKDGKTLPGKKGISLSVDQWNTLRNHAEDIEKALSDLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	KDEDVRASDDESETH CCCCCCCCCCCCCCC	34.72	23776212
19	Phosphorylation	VRASDDESETHAPAK CCCCCCCCCCCCCCC	55.58	23776212
21	Phosphorylation	ASDDESETHAPAKKV CCCCCCCCCCCCCCC	32.39	19376835
35	Phosphorylation	VAKPADDSDQSDDIV CCCCCCCCCCCCCEE	37.79	30291188
38	Phosphorylation	PADDSDQSDDIVVCN CCCCCCCCCCEEEEE	42.09	23776212
75	Phosphorylation	FYVKDGKTLPGKKGI EEEECCCCCCCCCCE	43.65	22074104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KIWI_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KIWI_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KIWI_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KELP_ARATH	KELP	physical	9681033
KIWI_ARATH	KIWI	physical	21798944

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15, AND MASSSPECTROMETRY.
PubMed: 19376835