HSP7F_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HSP7F_ARATH
• UniProt AC: Q9STW6
• Protein Name: Heat shock 70 kDa protein 6, chloroplastic
• Gene Name: HSP70-6
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 718
• Subcellular Localization: Plastid, chloroplast stroma .
• Protein Description: Acts redundantly with HSP70-7 in the thermotolerance of germinating seeds. Plays an important role in the protein precursor import into chloroplasts.; In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity)..
• Protein Sequence: MASSAAQIHVLGGIGFASSSSSKRNLNGKGGTFMPRSAFFGTRTGPFSTPTSAFLRMGTRNGGGASRYAVGPVRVVNEKVVGIDLGTTNSAVAAMEGGKPTIVTNAEGQRTTPSVVAYTKSGDRLVGQIAKRQAVVNPENTFFSVKRFIGRKMNEVDEESKQVSYRVVRDENNNVKLECPAINKQFAAEEISAQVLRKLVDDASRFLNDKVTKAVITVPAYFNDSQRTATKDAGRIAGLEVLRIINEPTAASLAYGFDRKANETILVFDLGGGTFDVSVLEVGDGVFEVLSTSGDTHLGGDDFDKRVVDWLAAEFKKDEGIDLLKDKQALQRLTEAAEKAKIELSSLTQTNMSLPFITATADGPKHIETTLTRAKFEELCSDLLDRVRTPVENSLRDAKLSFKDIDEVILVGGSTRIPAVQELVRKVTGKEPNVTVNPDEVVALGAAVQAGVLAGDVSDIVLLDVTPLSIGLETLGGVMTKIIPRNTTLPTSKSEVFSTAADGQTSVEINVLQGEREFVRDNKSLGSFRLDGIPPAPRGVPQIEVKFDIDANGILSVSAVDKGTGKKQDITITGASTLPKDEVDQMVQEAERFAKDDKEKRDAIDTKNQADSVVYQTEKQLKELGEKIPGEVKEKVEAKLQELKDKIGSGSTQEIKDAMAALNQEVMQIGQSLYNQPGAGGPGAGPSPGGEGASSGDSSSSKGGDGDDVIDADFTDSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	Phosphorylation	SAFLRMGTRNGGGAS HHHCCCCCCCCCCCC	16.18	29797451
111	Phosphorylation	TNAEGQRTTPSVVAY ECCCCCCCCCCEEEE	34.86	28295753
112	Phosphorylation	NAEGQRTTPSVVAYT CCCCCCCCCCEEEEE	18.76	28295753
114	Phosphorylation	EGQRTTPSVVAYTKS CCCCCCCCEEEEECC	27.42	28295753
119	Phosphorylation	TPSVVAYTKSGDRLV CCCEEEEECCCCHHH	14.70	28295753
153	Sulfoxidation	KRFIGRKMNEVDEES HHHHCCCHHCCCHHH	5.08	25693801
348	Phosphorylation	KIELSSLTQTNMSLP CCCHHHHCCCCCCCC	34.98	22092075
389	Phosphorylation	DLLDRVRTPVENSLR HHHHHCCCHHHHHHH	28.91	25561503
401	Phosphorylation	SLRDAKLSFKDIDEV HHHHCCCCCCCCCEE	29.55	23111157
488	Phosphorylation	KIIPRNTTLPTSKSE EEECCCCCCCCCHHH	34.00	29797451
524	Phosphorylation	EFVRDNKSLGSFRLD HEECCCCCCCCEEEC	44.19	23776212
527	Phosphorylation	RDNKSLGSFRLDGIP CCCCCCCCEEECCCC	16.70	23776212
612	Phosphorylation	DTKNQADSVVYQTEK CCCHHHHHHHHHHHH	19.25	30291188
615	Phosphorylation	NQADSVVYQTEKQLK HHHHHHHHHHHHHHH	13.94	25561503
617	Phosphorylation	ADSVVYQTEKQLKEL HHHHHHHHHHHHHHH	27.71	22074104
715	Phosphorylation	DVIDADFTDSQ---- CCCCCCCCCCC----	34.98	30291188
717	Phosphorylation	IDADFTDSQ------ CCCCCCCCC------	34.43	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HSP7F_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HSP7F_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HSP7F_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SUMO3_ARATH	SUMO3	physical	20855607

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.