dbPTM

MDHC2_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MDHC2_ARATH
UniProt AC	P57106
Protein Name	Malate dehydrogenase 2, cytoplasmic {ECO:0000305}
Gene Name	MDH2
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	332
Subcellular Localization	Cytoplasm.
Protein Description	Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments..
Protein Sequence	MAKEPVRVLVTGAAGQIGYALVPMIARGIMLGADQPVILHMLDIPFAAEALNGVKMELVDAAFPLLKGVVATTDAVEACTGVNVAVMVGGFPRKEGMERKDVMSKNVSIYKSQASALEKHAAPNCKVLVVANPANTNALILKEFAPSIPEKNITCLTRLDHNRALGQVSERLSVPVSDVKNVIIWGNHSSTQYPDVNHATVKTSVGEKPVRELVKNDEWLNGEFISTVQQRGAAIIKARKLSSALSAASSACDHIRDWVVGTPEGTFVSMGVYSDGSYNVPAGLIYSFPVTCRNGEWTIVQGLPIDDASRKKMDLTAEELKEEKDLAYSCLS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Acetylation	-----MAKEPVRVLV -----CCCCCEEEEE	62.34	21311031
173	Phosphorylation	GQVSERLSVPVSDVK HHHHHCCCCCHHHCC	30.51	25561503
177	Phosphorylation	ERLSVPVSDVKNVII HCCCCCHHHCCEEEE	30.53	19880383
242	Phosphorylation	IIKARKLSSALSAAS HHHHHHHHHHHHHHH	19.32	30291188
243	Phosphorylation	IKARKLSSALSAASS HHHHHHHHHHHHHHH	43.60	24601666
246	Phosphorylation	RKLSSALSAASSACD HHHHHHHHHHHHHCH	22.85	30291188
249	Phosphorylation	SSALSAASSACDHIR HHHHHHHHHHCHHHH	20.41	27643528
250	Phosphorylation	SALSAASSACDHIRD HHHHHHHHHCHHHHH	28.34	27643528
316	Phosphorylation	SRKKMDLTAEELKEE HHHHCCCCHHHHHHH	27.97	19880383
332	Phosphorylation	DLAYSCLS------- HHHHHHCC-------	42.37	29654922

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MDHC2_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MDHC2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MDHC2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MDHC2_ARATH !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MDHC2_ARATH

Related Literatures of Post-Translational Modification