LONM1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LONM1_ARATH
• UniProt AC: P93655
• Protein Name: Lon protease homolog 1, mitochondrial
• Gene Name: LON1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 940
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner..
• Protein Sequence: MLKLFTSSASRVHHLTPVSRVVGSSPVESPLFKALSQITGWNRRSTSLGHRAFFCSEPTNGEAAAEAETKAVESDSEVSDSKSSSAIVPTNPRPEDCLTVLALPVPHRPLFPGFYMPIYVKDPKVLAALQESRRRQAPYAGAFLLKDDPSADSSSSTDAEKNINELKGKELLNRLHEVGTLAQISSIQGDQVILVGHRRLRIKEMVSEEPLTVKVDHLKDNPFDMDDDVVKATSFEVISTLRDVLKTSSLWRDHVQTYTQHIGDFTYPRLADFGAAICGANRHQAQEVLEELDVHKRLRLTLELMKKEMEISKIQETIAKAIEEKISGEQRRYLLNEQLKAIKKELGVETDDKSALSAKFKERIEPNKEKIPAHVLQVIEEELTKLQLLEASSSEFNVTRNYLDWLTILPWGNYSNENFDVARAQTILDEDHYGLSDVKERILEFIAVGRLRGTSQGKIICLSGPPGVGKTSIGRSIARALNRKFFRFSVGGLADVAEIKGHRRTYVGAMPGKMVQCLKSVGTANPLVLIDEIDKLGRGHAGDPASALLELLDPEQNANFLDHYLDVTIDLSKVLFVCTANVIDMIPNPLLDRMEVISIAGYITDEKVHIARDYLEKTARGDCGVKPEQVEVSDAALLSLIENYCREAGVRNLQKQIEKIYRKIALKLVREGAVPEEPAVASDPEEAEIVADVGESIENHTVEENTVSSAEEPKEEAQTEKIAIETVMIDESNLADYVGKPVFHAEKLYEQTPVGVVMGLAWTSMGGSTLYIETTVVEEGEGKGGLNITGQLGDVMKESAQIAHTVARKIMLEKEPENQFFANSKLHLHVPAGATPKDGPSAGCTMITSLLSLATKKPVRKDLAMTGEVTLTGRILPIGGVKEKTIAARRSQIKTIIFPEANRRDFDELAENVKEGLNVHFVDDYGKIFELAFGYDKQED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Phosphorylation	SPLFKALSQITGWNR CHHHHHHHHHHCCCC	25.13	23111157
47	Phosphorylation	GWNRRSTSLGHRAFF CCCCCCCCCCCCEEE	33.33	23111157
74	Phosphorylation	AETKAVESDSEVSDS HHHHHHHCCCCCCCC	39.58	19880383
76	Phosphorylation	TKAVESDSEVSDSKS HHHHHCCCCCCCCCC	49.53	23776212
79	Phosphorylation	VESDSEVSDSKSSSA HHCCCCCCCCCCCCC	31.92	19376835
81	Phosphorylation	SDSEVSDSKSSSAIV CCCCCCCCCCCCCCC	27.25	19376835
214	Acetylation	SEEPLTVKVDHLKDN CCCCCEEEEEHHCCC	36.39	24727099
682	Phosphorylation	PEEPAVASDPEEAEI CCCCCCCCCHHHCEE	47.28	30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LONM1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LONM1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LONM1_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of LONM1_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Site-specific phosphorylation profiling of Arabidopsis proteins bymass spectrometry and peptide chip analysis.";
de la Fuente van Bentem S., Anrather D., Dohnal I., Roitinger E.,Csaszar E., Joore J., Buijnink J., Carreri A., Forzani C.,Lorkovic Z.J., Barta A., Lecourieux D., Verhounig A., Jonak C.,Hirt H.;
J. Proteome Res. 7:2458-2470(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74, AND MASSSPECTROMETRY.
PubMed: 18433157