CYSK1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CYSK1_ARATH
• UniProt AC: P47998
• Protein Name: Cysteine synthase 1
• Gene Name: OASA1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 322
• Subcellular Localization: Cytoplasm.
• Protein Description: Acts as a major cysteine synthase, probably involved in maintaining organic sulfur level..
• Protein Sequence: MASRIAKDVTELIGNTPLVYLNNVAEGCVGRVAAKLEMMEPCSSVKDRIGFSMISDAEKKGLIKPGESVLIEPTSGNTGVGLAFTAAAKGYKLIITMPASMSTERRIILLAFGVELVLTDPAKGMKGAIAKAEEILAKTPNGYMLQQFENPANPKIHYETTGPEIWKGTGGKIDGFVSGIGTGGTITGAGKYLKEQNANVKLYGVEPVESAILSGGKPGPHKIQGIGAGFIPSVLNVDLIDEVVQVSSDESIDMARQLALKEGLLVGISSGAAAAAAIKLAQRPENAGKLFVAIFPSFGERYLSTVLFDATRKEAEAMTFEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASRIAKDV ------CCHHHHHHH	13.91	20658158
10	Phosphorylation	SRIAKDVTELIGNTP HHHHHHHHHHHCCCC	34.90	22092075
46	N6-(pyridoxal phosphate)lysine	MEPCSSVKDRIGFSM CCCCCCCHHHHCCCC	43.14	-
46	Other	MEPCSSVKDRIGFSM CCCCCCCHHHHCCCC	43.14	16166087
52	Phosphorylation	VKDRIGFSMISDAEK CHHHHCCCCCCHHHH	15.25	22092075
53	Sulfoxidation	KDRIGFSMISDAEKK HHHHCCCCCCHHHHC	2.95	25693801
75	Phosphorylation	SVLIEPTSGNTGVGL EEEEECCCCCCCCHH	40.54	29654922
78	Phosphorylation	IEPTSGNTGVGLAFT EECCCCCCCCHHHHH	36.45	29654922
85	Phosphorylation	TGVGLAFTAAAKGYK CCCHHHHHHHHCCCE	15.13	29654922
160	Phosphorylation	NPKIHYETTGPEIWK CCCEEEECCCCHHHC	29.86	22092075
178	Phosphorylation	GKIDGFVSGIGTGGT CCCCCEEEECCCCCC	23.56	22092075
185	Phosphorylation	SGIGTGGTITGAGKY EECCCCCCCCCHHHH	19.40	30291188
302	Nitration	FPSFGERYLSTVLFD ECCCHHHHHHHHHHC	10.74	-
302	Phosphorylation	FPSFGERYLSTVLFD ECCCHHHHHHHHHHC	10.74	22092075
318	Sulfoxidation	TRKEAEAMTFEA--- CHHHHHHHCCCC---	3.12	25693801

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CYSK1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CYSK1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CYSK1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SAT1_ARATH	SERAT2;1	physical	17425333
SAT1_ARATH	SERAT2;1	physical	17194764
SAT3_ARATH	SERAT2;2	physical	9076992
SUT12_ARATH	SULTR1;2	physical	20529854

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.