G3PC1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: G3PC1_ARATH
• UniProt AC: P25858
• Protein Name: Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic
• Gene Name: GAPC1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 338
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Essential for the maintenance of cellular ATP levels and carbohydrate metabolism. Required for full fertility. [PubMed: 18820081 Involved in response to oxidative stress by mediating plant responses to abscisic acid (ABA) and water deficits through the activation of PLDDELTA and production of phosphatidic acid (PA), a multifunctional stress signaling lipid in plants]
• Protein Sequence: MADKKIRIGINGFGRIGRLVARVVLQRDDVELVAVNDPFITTEYMTYMFKYDSVHGQWKHNELKIKDEKTLLFGEKPVTVFGIRNPEDIPWAEAGADYVVESTGVFTDKDKAAAHLKGGAKKVVISAPSKDAPMFVVGVNEHEYKSDLDIVSNASCTTNCLAPLAKVINDRFGIVEGLMTTVHSITATQKTVDGPSMKDWRGGRAASFNIIPSSTGAAKAVGKVLPALNGKLTGMSFRVPTVDVSVVDLTVRLEKAATYDEIKKAIKEESEGKLKGILGYTEDDVVSTDFVGDNRSSIFDAKAGIALSDKFVKLVSWYDNEWGYSSRVVDLIVHMSKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	Phosphorylation	LKIKDEKTLLFGEKP EECCCCEEEEECCCC		22092075
130	Acetylation	VVISAPSKDAPMFVV EEEECCCCCCCEEEE		21311031
152	Phosphorylation	KSDLDIVSNASCTTN CCCCEECCCCCCCCC		23776212
155	Phosphorylation	LDIVSNASCTTNCLA CEECCCCCCCCCCHH		30291188
156	S-nitrosylation	DIVSNASCTTNCLAP EECCCCCCCCCCHHH		-
156	Glutathionylation	DIVSNASCTTNCLAP EECCCCCCCCCCHHH		16286078
157	Phosphorylation	IVSNASCTTNCLAPL ECCCCCCCCCCHHHH		30291188
158	Phosphorylation	VSNASCTTNCLAPLA CCCCCCCCCCHHHHH		26811356
160	S-nitrosylation	NASCTTNCLAPLAKV CCCCCCCCHHHHHHH		-
160	Glutathionylation	NASCTTNCLAPLAKV CCCCCCCCHHHHHHH		22833525
179	Sulfoxidation	FGIVEGLMTTVHSIT CCHHHHHHHHHHHEE		23289948
180	Phosphorylation	GIVEGLMTTVHSITA CHHHHHHHHHHHEEE		22092075
181	Phosphorylation	IVEGLMTTVHSITAT HHHHHHHHHHHEEEE		26811356
184	Phosphorylation	GLMTTVHSITATQKT HHHHHHHHEEEEECC		26811356
186	Phosphorylation	MTTVHSITATQKTVD HHHHHHEEEEECCCC		24601666
188	Phosphorylation	TVHSITATQKTVDGP HHHHEEEEECCCCCC		23111157
196	Phosphorylation	QKTVDGPSMKDWRGG ECCCCCCCCCCCCCC		25561503
207	Phosphorylation	WRGGRAASFNIIPSS CCCCCCEEEEEECCC		30291188
213	Phosphorylation	ASFNIIPSSTGAAKA EEEEEECCCCCHHHH		23776212
214	Phosphorylation	SFNIIPSSTGAAKAV EEEEECCCCCHHHHH		23776212
215	Phosphorylation	FNIIPSSTGAAKAVG EEEECCCCCHHHHHH		23776212
219	Acetylation	PSSTGAAKAVGKVLP CCCCCHHHHHHHHHH		21311031
233	Phosphorylation	PALNGKLTGMSFRVP HHHCCEEECEEEECC		23111157
236	Phosphorylation	NGKLTGMSFRVPTVD CCEEECEEEECCCCC		30291188
241	Phosphorylation	GMSFRVPTVDVSVVD CEEEECCCCCEEEEE		26811356
255	Acetylation	DLTVRLEKAATYDEI EEEEEHHHHCCHHHH		21311031
258	Phosphorylation	VRLEKAATYDEIKKA EEHHHHCCHHHHHHH		25561503
281	Phosphorylation	LKGILGYTEDDVVST EEEECCCCCCCEEEC		29797451
288	Phosphorylation	TEDDVVSTDFVGDNR CCCCEEECCCCCCCH		29797451
308	Phosphorylation	AKAGIALSDKFVKLV HHCCEECCHHHHHHH		30407730
310	Acetylation	AGIALSDKFVKLVSW CCEECCHHHHHHHEE		24727099

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of G3PC1_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
156	C	Glutathionylation	S-glutathionylation at Cys-156 in the presence of oxidized glutathione (GSSG).	22607208

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of G3PC1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VDAC3_ARATH	VDAC3	physical	23316205
G3PC1_ARATH	GAPC1	physical	23316205
G3PC2_ARATH	GAPC2	physical	23316205

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.