G3PC2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: G3PC2_ARATH
• UniProt AC: Q9FX54
• Protein Name: Glyceraldehyde-3-phosphate dehydrogenase GAPC2, cytosolic
• Gene Name: GAPC2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 338
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Essential for the maintenance of cellular ATP levels and carbohydrate metabolism (By similarity). Binds DNA in vitro..
• Protein Sequence: MADKKIRIGINGFGRIGRLVARVVLQRDDVELVAVNDPFITTEYMTYMFKYDSVHGQWKHHELKVKDDKTLLFGEKPVTVFGIRNPEDIPWGEAGADFVVESTGVFTDKDKAAAHLKGGAKKVVISAPSKDAPMFVVGVNEHEYKSDLDIVSNASCTTNCLAPLAKVINDRFGIVEGLMTTVHSITATQKTVDGPSMKDWRGGRAASFNIIPSSTGAAKAVGKVLPSLNGKLTGMSFRVPTVDVSVVDLTVRLEKAATYDEIKKAIKEESEGKMKGILGYTEDDVVSTDFVGDNRSSIFDAKAGIALSDKFVKLVSWYDNEWGYSSRVVDLIVHMSKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	Phosphorylation	LKVKDDKTLLFGEKP EEECCCCEEEECCCC		22092075
130	Acetylation	VVISAPSKDAPMFVV EEEECCCCCCCEEEE		-
134	Sulfoxidation	APSKDAPMFVVGVNE CCCCCCCEEEEECCC		25693801
152	Phosphorylation	KSDLDIVSNASCTTN CCCCEECCCCCCCCC		23776212
155	Phosphorylation	LDIVSNASCTTNCLA CEECCCCCCCCCCHH		30291188
156	Glutathionylation	DIVSNASCTTNCLAP EECCCCCCCCCCHHH		16286078
156	S-nitrosylation	DIVSNASCTTNCLAP EECCCCCCCCCCHHH		18298409
157	Phosphorylation	IVSNASCTTNCLAPL ECCCCCCCCCCHHHH		30291188
158	Phosphorylation	VSNASCTTNCLAPLA CCCCCCCCCCHHHHH		26811356
160	S-nitrosylation	NASCTTNCLAPLAKV CCCCCCCCHHHHHHH		18298409
179	Sulfoxidation	FGIVEGLMTTVHSIT CCHHHHHHHHHHHEE		23289948
180	Phosphorylation	GIVEGLMTTVHSITA CHHHHHHHHHHHEEE		22092075
181	Phosphorylation	IVEGLMTTVHSITAT HHHHHHHHHHHEEEE		26811356
184	Phosphorylation	GLMTTVHSITATQKT HHHHHHHHEEEEECC		26811356
186	Phosphorylation	MTTVHSITATQKTVD HHHHHHEEEEECCCC		24601666
188	Phosphorylation	TVHSITATQKTVDGP HHHHEEEEECCCCCC		23111157
196	Phosphorylation	QKTVDGPSMKDWRGG ECCCCCCCCCCCCCC		25561503
197	Sulfoxidation	KTVDGPSMKDWRGGR CCCCCCCCCCCCCCC		25693801
207	Phosphorylation	WRGGRAASFNIIPSS CCCCCCEEEEEECCC		30291188
213	Phosphorylation	ASFNIIPSSTGAAKA EEEEEECCCCCHHHH		23776212
214	Phosphorylation	SFNIIPSSTGAAKAV EEEEECCCCCHHHHH		23776212
215	Phosphorylation	FNIIPSSTGAAKAVG EEEECCCCCHHHHHH		23776212
219	Acetylation	PSSTGAAKAVGKVLP CCCCCHHHHHHHHHH		-
223	Acetylation	GAAKAVGKVLPSLNG CHHHHHHHHHHHHCC		21311031
227	Phosphorylation	AVGKVLPSLNGKLTG HHHHHHHHHCCEEEC		25561503
233	Phosphorylation	PSLNGKLTGMSFRVP HHHCCEEECEEEECC		23111157
236	Phosphorylation	NGKLTGMSFRVPTVD CCEEECEEEECCCCC		30291188
241	Phosphorylation	GMSFRVPTVDVSVVD CEEEECCCCCEEEEE		26811356
255	Acetylation	DLTVRLEKAATYDEI EEEEEHHHHCCHHHH		-
258	Phosphorylation	VRLEKAATYDEIKKA EEHHHHCCHHHHHHH		25561503
281	Phosphorylation	MKGILGYTEDDVVST CCEECCCCCCCEEEC		29797451
288	Phosphorylation	TEDDVVSTDFVGDNR CCCCEEECCCCCCCH		29797451
308	Phosphorylation	AKAGIALSDKFVKLV HHCCEECCHHHHHHH		30407730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of G3PC2_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
156	C	Glutathionylation	S-glutathionylation at Cys-156 in the presence of oxidized glutathione (GSSG).	18298409
156	C	S-nitrosylation	S-nitrosylation at Cys-156 and Cys-160 in the presence of S-nitrosoglutathione (GSNO) or sodium nitroprusside (SNP).	18298409
160	C	S-nitrosylation	S-nitrosylation at Cys-156 and Cys-160 in the presence of S-nitrosoglutathione (GSNO) or sodium nitroprusside (SNP).	18298409

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of G3PC2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VDAC3_ARATH	VDAC3	physical	23316205
G3PC2_ARATH	GAPC2	physical	23316205
G3PC1_ARATH	GAPC1	physical	23316205
G3PC1_ARATH	GAPC1	physical	25293756

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.