GLN12_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLN12_ARATH
• UniProt AC: Q8LCE1
• Protein Name: Glutamine synthetase cytosolic isozyme 1-2
• Gene Name: GLN1-2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 356
• Subcellular Localization: Cytoplasm.
• Protein Description: Low-affinity glutamine synthetase. May contribute to the homeostatic control of glutamine synthesis in roots..
• Protein Sequence: MSLLADLVNLDISDNSEKIIAEYIWVGGSGMDMRSKARTLPGPVTDPSKLPKWNYDGSSTGQAPGQDSEVILYPQAIFKDPFRRGNNILVMCDAYTPAGEPIPTNKRHAAAEIFANPDVIAEVPWYGIEQEYTLLQKDVNWPLGWPIGGFPGPQGPYYCSIGADKSFGRDIVDAHYKASLYAGINISGINGEVMPGQWEFQVGPSVGISAADEIWIARYILERITEIAGVVVSFDPKPIPGDWNGAGAHTNYSTKSMREEGGYEIIKKAIEKLGLRHKEHISAYGEGNERRLTGHHETADINTFLWGVANRGASIRVGRDTEKEGKGYFEDRRPASNMDPYVVTSMIAETTLLWNP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSLLADLVN ------CCHHHHHHC	31.90	22223895
2	Phosphorylation	------MSLLADLVN ------CCHHHHHHC	31.90	19376835
13	Phosphorylation	DLVNLDISDNSEKII HHHCCCCCCCCCCEE	30.33	24243849
16	Phosphorylation	NLDISDNSEKIIAEY CCCCCCCCCCEEEEE	45.30	24243849
39	Phosphorylation	DMRSKARTLPGPVTD CHHHHCCCCCCCCCC	42.01	24299221
48	Phosphorylation	PGPVTDPSKLPKWNY CCCCCCHHHCCCCCC	50.03	-
257	Sulfoxidation	TNYSTKSMREEGGYE CCCCCHHHHHHCHHH	7.15	25693801
282	Phosphorylation	LRHKEHISAYGEGNE CCCHHHHHCCCCCCC	19.83	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLN12_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLN12_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLN12_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of GLN12_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, AND MASSSPECTROMETRY.
PubMed: 19376835