RGP2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RGP2_ARATH
• UniProt AC: Q9LFW1
• Protein Name: UDP-arabinopyranose mutase 2 {ECO:0000305}
• Gene Name: RGP2 {ECO:0000303|PubMed:21478444}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 360
• Subcellular Localization: Cytoplasm, cytosol. Golgi apparatus. Soluble and membrane-associated.
• Protein Description: UDP-L-arabinose mutase involved in the biosynthesis of cell wall non-cellulosic polysaccharides. Catalyzes the interconvertion of UDP-L-arabinopyranose (UDP-Arap) and UDP-L-arabinofuranose (UDP-Araf) in vitro. Preferentially catalyzes the formation of UDP-Arap from UDP-Araf. At thermodynamic equilibrium in vitro the ratio of the pyranose form over the furanose form is 95:5. Is not active on other UDP-sugars (UDP-Gal, UDP-Xyl, UDP-Glc, GDP-Man and GDP-Fuc). [PubMed: 21478444 Functions redundantly with RGP2 and is essential for proper cell walls and pollen development. Probably involved in the formation of the pectocellulosic cell wall layer intine. Is probably active as heteromer in vivo]
• Protein Sequence: MVEPANTVGLPVNPTPLLKDELDIVIPTIRNLDFLEMWRPFLQPYHLIIVQDGDPSKKIHVPEGYDYELYNRNDINRILGPKASCISFKDSACRCFGYMVSKKKYIFTIDDDCFVAKDPSGKAVNALEQHIKNLLCPSSPFFFNTLYDPYREGADFVRGYPFSLREGVSTAVSHGLWLNIPDYDAPTQLVKPKERNTRYVDAVMTIPKGTLFPMCGMNLAFDRDLIGPAMYFGLMGDGQPIGRYDDMWAGWCIKVICDHLSLGVKTGLPYIYHSKASNPFVNLKKEYKGIFWQEEIIPFFQNAKLSKEAVTVQQCYIELSKMVKEKLSSLDPYFDKLADAMVTWIEAWDELNPPAASGKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MVEPANTVG ------CCCCCCCCC	14.01	22223895
7	Phosphorylation	-MVEPANTVGLPVNP -CCCCCCCCCCCCCC	20.32	25368622
15	Phosphorylation	VGLPVNPTPLLKDEL CCCCCCCCCCCCCHH	22.74	25368622
158	N-linked_Glycosylation	REGADFVRGYPFSLR CCCCCCCCCCCCCHH	38.63	-
277	Phosphorylation	YIYHSKASNPFVNLK EEECCCCCCCCCCCC	49.09	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RGP2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RGP2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RGP2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RGP5_ARATH	AT5G16510	physical	21798944

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.