MPK9_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MPK9_ARATH
• UniProt AC: Q9LV37
• Protein Name: Mitogen-activated protein kinase 9
• Gene Name: MPK9
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 510
• Protein Sequence: MDPHKKVALETEFFTEYGEASRYQIQEVIGKGSYGVVASAIDTHSGEKVAIKKINDVFEHVSDATRILREIKLLRLLRHPDIVEIKHVMLPPSRREFRDIYVVFELMESDLHQVIKANDDLTPEHYQFFLYQLLRGLKFIHTANVFHRDLKPKNILANSDCKLKICDFGLARVSFNDAPSAIFWTDYVATRWYRAPELCGSFFSKYTPAIDIWSIGCIFAEMLTGKPLFPGKNVVHQLDIMTDLLGTPPPEAIARIRNEKARRYLGNMRRKPPVPFTHKFPHVDPLALRLLHRLLAFDPKDRPSAEEALADPYFYGLANVDREPSTQPIPKLEFEFERRKITKEDVRELIYREILEYHPQMLQEYLRGGEQTSFMYPSGVDRFKRQFAHLEENYGKGEKGSPLQRQHASLPRERVPAPKKENGSHNHDIENRSIASLVTTLESPPTSQHEGSDYRNGTSQTGYSARSLLKSASISASKCIGMKPRNKSEYGESNNDTVDALSQKVAALHT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
185	Phosphorylation	APSAIFWTDYVATRW CCCHHEECHHCCCCC	13.50	24894044
187	Phosphorylation	SAIFWTDYVATRWYR CHHEECHHCCCCCCC	5.66	30291188
190	Phosphorylation	FWTDYVATRWYRAPE EECHHCCCCCCCCHH	16.22	22074104
401	Phosphorylation	YGKGEKGSPLQRQHA CCCCCCCCHHHHHHC	33.24	29654922
409	Phosphorylation	PLQRQHASLPRERVP HHHHHHCCCCHHHCC	36.46	29654922
433	Phosphorylation	NHDIENRSIASLVTT CCCCCCCHHHHHHHH	33.80	23776212
436	Phosphorylation	IENRSIASLVTTLES CCCCHHHHHHHHCCC	23.00	23776212
439	Phosphorylation	RSIASLVTTLESPPT CHHHHHHHHCCCCCC	30.84	23776212
440	Phosphorylation	SIASLVTTLESPPTS HHHHHHHHCCCCCCC	22.50	23776212
443	Phosphorylation	SLVTTLESPPTSQHE HHHHHCCCCCCCCCC	39.01	30291188
446	Phosphorylation	TTLESPPTSQHEGSD HHCCCCCCCCCCCCC	44.39	23776212
447	Phosphorylation	TLESPPTSQHEGSDY HCCCCCCCCCCCCCC	35.00	23776212
452	Phosphorylation	PTSQHEGSDYRNGTS CCCCCCCCCCCCCCC	28.60	23776212
454	Phosphorylation	SQHEGSDYRNGTSQT CCCCCCCCCCCCCCC	14.00	23776212
473	Phosphorylation	RSLLKSASISASKCI HHHHHHCCCCHHHHC	24.94	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MPK9_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
185	T	Phosphorylation	Dually phosphorylated on Thr-185 and Tyr-187, which activates the enzyme.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MPK9_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MPK9_ARATH	MPK9	physical	25646663

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.