dbPTM

ETOL2_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ETOL2_ARATH
UniProt AC	Q9LV01
Protein Name	ETO1-like protein 2
Gene Name	EOL2
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	925
Subcellular Localization
Protein Description	Potential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. May act as a substrate-specific adapter that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes (By similarity)..
Protein Sequence	MRNLKLFERFKSTQVHAFTTQDSPSTSSNGSPRMMKFLGHPKSKSRSLLPHGFPTTDLLEPPLDSYLKPIDLVESLSNLYRRIESSSESEASMLYLEQYAVLRSLGDAKLLRRCLLNARRHAIDVPCKVVFSAWLRFFRREHELVGVESMDCNGLASECPKTSLTHGCDLNVDDEGCECSTVCEDEFGSDDVKISKADEFSGLDEVSDISFCVGSEKAKCVRSRIAALSRPFEAMLYGSFVESTTSEIDFSENGISIEAMLALNIYSRIKRVDLFRVETVFELLQLASKFCCDDLKSECEARLAASVTDLDKALTFVEYALEERTTLLLSACLQVFLRELPQSLHNPKVMRFFCSSEAKEQLAFLGSECVFLLYYFLSQVGMEEKLTTDTMLILLERTREFARTNWQKALSLHQMGCVLFERKDYKAAQFHFRLASSLGHVYSLAGVSRTEYKQGKRYSAYRLMNFLISNHKPHGWMYQERSLYNVGVEKLKDLATATELDPTLSFPYKYRAVMKFEQKQIKEAFQEIDRLIQFKLSPECLELRAWLYLATGDRESCLRDLRAVLSLEPNYVVFGGKMRDDLVEALTAQCIEVESEADCWVRLFDRWSAVDDVASLAVVHQMLQNDPSKNFLRFRQSLLLLRLNCQGAAMRCLRMAWNLATSEAERLVYEGWLLYDMGYVEETLTKAEEAISIQRSFEAFFLKAYALADKNLDADEISCVVQVLEEALKCPSDGLRKGQALNNLGSIYINLGMLDQAETAYKNAIEIKHIRARQGLARVYFLKNQRKEACEEMTKLIEKSCSKAAAYEKRSEYCEREKAKEDLDMATTLDPLRTYPYRYRAAVLMDDQRETEAVEELSKAIAFRPELQTLHLRAAFHEATGNLSLATQDCEAALCLDPNHTETLHLYSRSKDQASSIDNTIFGLD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
86	Phosphorylation	LYRRIESSSESEASM HHHHHHCCCHHHHHH	25.90	22074104
99	Phosphorylation	SMLYLEQYAVLRSLG HHHHHHHHHHHHHHC	6.84	22074104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ETOL2_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ETOL2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ETOL2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
1A15_ARATH	ACS5	physical	15118728
1A15_ARATH	ACS5	physical	23512855
UBQ3_ARATH	UBQ3	physical	23512855

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ETOL2_ARATH

Related Literatures of Post-Translational Modification