1A15_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 1A15_ARATH
• UniProt AC: Q37001
• Protein Name: 1-aminocyclopropane-1-carboxylate synthase 5
• Gene Name: ACS5
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 470
• Protein Description: 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes catalyze the conversion of S-adenosyl-L-methionine (SAM) into 1-aminocyclopropane-1-carboxylate (ACC), a direct precursor of ethylene..
• Protein Sequence: MKQLSTKVTSNGHGQDSSYFLGWEEYEKNPYDEIKNPNGMIQMGLAENQLCFDLIESWLTKNPDAASLKRNGQSIFRELALFQDYHGMPEFKKAMAEFMEEIRGNRVTFDPKKIVLAAGSTSANETLMFCLAEPGDAFLLPTPYYPGFDRDLKWRTGAEIVPIHCSSSNGFQITESALQQAYQQAQKLDLKVKGVLVTNPSNPLGTALTRRELNLLVDFITSKNIHLISDEIYSGTMFGFEQFISVMDVLKDKKLEDTEVSKRVHVVYSLSKDLGLPGFRVGAIYSNDEMIVSAATKMSSFGLVSSQTQYLLSALLSDKKFTSQYLEENQKRLKSRQRRLVSGLESAGITCLRSNAGLFCWVDMRHLLDTNTFEAELDLWKKIVYNVKLNISPGSSCHCTEPGWFRVCFANMSEDTLDLALKRLKTFVESTDCGRMISRSSHERLKSLRKKTVSNWVFRVSWTDRVPDER

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
272	N6-(pyridoxal phosphate)lysine	HVVYSLSKDLGLPGF EEEEECCCCCCCCCE	63.37	-
272	Other	HVVYSLSKDLGLPGF EEEEECCCCCCCCCE	63.37	-
323	Phosphorylation	LSDKKFTSQYLEENQ HCCCCHHHHHHHHHH	21.69	22074104
461	Phosphorylation	SNWVFRVSWTDRVPD CCEEEEEECCCCCCC	21.72	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	ETO1	O65020	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 1A15_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 1A15_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ETO1_ARATH	ETO1	physical	15118728
14332_ARATH	GRF2	physical	23512855

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.