HAC1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HAC1_ARATH
• UniProt AC: Q9C5X9
• Protein Name: Histone acetyltransferase HAC1
• Gene Name: HAC1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1697
• Subcellular Localization: Nucleus .
• Protein Description: Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation..
• Protein Sequence: MNVQAHMSGQVSNQGTMSQQNGNSQMQNLVGGGSAPATGAGLGPSRVSPVDNDILKLRQAMRIRIFNILQQKQPSPADEASKAKYMDVARRLEEGLFKIANTKEDYVNPSTLEPRLASLIKGRQLNNYNQRHANSSSVGTMIPTPGLQHSGGNPNLMITSSGDATMAGSNNITTSAMNTGNLLNSGGMLGGNLSNGYQHSSSNFGLGSGGNMSSMSSQRNTGQMMPTPGFVNSSTNNNSNNGQSYLSVEASNNSGGFSTAPMMVPQTQQQQLRQDIGGQNSRMLQNHGSQMGVGLRPGMQQKLSNVSNSSINGGVGMNAKSVDSGTSYTNPIRNSQQAYDNLQRSGMQGDGYGTNNSDPFGSGNLYGAVTSVGMMTNTQNANTASFQAVSRTSSSLSHQQQQFQQQPNRFQQQPNQFHQQQQQFLHQQQLKQQSQQQQRFISHDAFGQNNVASDMVTHVKHEPGMENPSESIHSQTPEQFQLSQFQNQYQNNAEDRHAGSQILPVTSQSDMCTSVPQNSQQIQQMLHPHSMASDSVNGFSNLSVGVKTESGMRGHWQSQSQEHTQMSNSMSNERHIQEDFRQRMSGTDEAQPNNMSGGSIIGQNRVSTTSESLNPQNPTATTCRNGNGNRDPRFKNQQKWLLFLRHARHCKAPEGKCPDRNCVTVQKLWKHMDSCAAPQCSYPRCLPTKTLINHHRSCKEPNCPVCIPVKAYLQQQANARSLARLKNETDAARSVNGGGISSDAVQTSAGAKSCTSPGADISGHLQPSLKRLKVEQSSQPVDVETESCKSSVVSVTEAQSSQYAERKDHKHSDVRAPSKYFEVKAEVSDFSVQTRPGFKDTKIGIAENIPKQRPVSQPDKQDLSDVSPMQETTKVEKEPESLKKENLAESTEHTSKSGKPEIKGVSLTELFTPEQVREHIRGLRQWVGQSKAKAEKNQAMEHSMSENSCQLCAVEKLTFEPPPIYCTPCGARIKRNAMYYTVGAGDTRHYFCIPCYNESRGDTILAEGTPMPKARLEKKKNDEETEEWWVQCDKCEAWQHQICALFNGRRNDGGQAEYTCPYCFIAEVEQSKRKPLPQSAVLGAKDLPRTILSDHIEQRLFKRLKQERTERARAQGKSYDEIPTAESLVIRVVSSVDKKLEVKPRFLEIFREDSYPTEFAYKSKVVLLFQKIEGVEVCLFGMYVQEFGSECAFPNQRRVYLSYLDSVKYFRPEVRSYNGEALRTFVYHEILIGYLEYCKLRGFTSCYIWACPPLKGEDYILYCHPEIQKTPKSDKLREWYLAMLRKASKEGIVAETINLYDHFFMQTGECRAKVTAARLPYFDGDYWPGAAEDLIYQMSQEEDGRKGNKKGMLKKTITKRALKASGQTDLSGNASKDLLLMHRLGETIHPMKEDFIMVHLQPSCTHCCILMVSGNRWVCSQCKHFQICDKCYEAEQRREDRERHPVNFKDKHALYPVEIMDIPADTRDKDEILESEFFDTRQAFLSLCQGNHYQYDTLRRAKHSSMMVLYHLHNPTAPAFVTTCNACHLDIETGQGWRCEVCPDYDVCNACFSRDGGVNHPHKLTNHPSLADQNAQNKEARQLRVLQLRKMLDLLVHASQCRSAHCQYPNCRKVKGLFRHGINCKVRASGGCVLCKKMWYLLQLHARACKESECHVPRCRDLKEHLRRLQQQSDSRRRAAVMEMMRQRAAEVAGGSG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
392	Phosphorylation	SFQAVSRTSSSLSHQ HHHHHHHCCCCCHHH	26.00	25561503
393	Phosphorylation	FQAVSRTSSSLSHQQ HHHHHHCCCCCHHHH	19.47	25561503
394	Phosphorylation	QAVSRTSSSLSHQQQ HHHHHCCCCCHHHHH	34.38	25561503
395	Phosphorylation	AVSRTSSSLSHQQQQ HHHHCCCCCHHHHHH	33.39	29654922
397	Phosphorylation	SRTSSSLSHQQQQFQ HHCCCCCHHHHHHHH	22.62	25561503
753	Phosphorylation	QTSAGAKSCTSPGAD HHCCCCCCCCCCCCC	23.30	23776212
755	Phosphorylation	SAGAKSCTSPGADIS CCCCCCCCCCCCCCC	45.08	23776212
756	Phosphorylation	AGAKSCTSPGADISG CCCCCCCCCCCCCCC	26.18	23776212
762	Phosphorylation	TSPGADISGHLQPSL CCCCCCCCCCCCHHH	22.25	23776212
768	Phosphorylation	ISGHLQPSLKRLKVE CCCCCCHHHCCCCCE	33.30	23776212
867	Phosphorylation	KQDLSDVSPMQETTK CCCCCCCCCCCCCCC	21.46	25561503
980	Phosphorylation	IKRNAMYYTVGAGDT EECCCCEEEECCCCC	5.05	28295753
981	Phosphorylation	KRNAMYYTVGAGDTR ECCCCEEEECCCCCE	8.58	28295753
987	Phosphorylation	YTVGAGDTRHYFCIP EEECCCCCEEEEEEE	20.59	28295753

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HAC1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HAC1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HAC1_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of HAC1_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.