| UniProt ID | MDHC1_ARATH | |
|---|---|---|
| UniProt AC | P93819 | |
| Protein Name | Malate dehydrogenase 1, cytoplasmic {ECO:0000305} | |
| Gene Name | MDH1 | |
| Organism | Arabidopsis thaliana (Mouse-ear cress). | |
| Sequence Length | 332 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments.. | |
| Protein Sequence | MAKEPVRVLVTGAAGQIGYALVPMIARGIMLGADQPVILHMLDIPPAAEALNGVKMELIDAAFPLLKGVVATTDAVEGCTGVNVAVMVGGFPRKEGMERKDVMSKNVSIYKSQAAALEKHAAPNCKVLVVANPANTNALILKEFAPSIPEKNISCLTRLDHNRALGQISERLSVPVSDVKNVIIWGNHSSSQYPDVNHAKVQTSSGEKPVRELVKDDAWLDGEFISTVQQRGAAIIKARKLSSALSAASSACDHIRDWVLGTPEGTFVSMGVYSDGSYSVPSGLIYSFPVTCRNGDWSIVQGLPIDEVSRKKMDLTAEELKEEKDLAYSCLS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Acetylation | -----MAKEPVRVLV -----CCCCCEEEEE | 62.34 | - | |
| 41 | Sulfoxidation | DQPVILHMLDIPPAA CCCEEEEECCCCHHH | 3.01 | 23289948 | |
| 56 | Oxidation | EALNGVKMELIDAAF HHHCCCCHHHHHHHH | 4.75 | 29194485 | |
| 97 | Oxidation | GFPRKEGMERKDVMS CCCCCCCCCHHHHHH | 4.76 | 29194485 | |
| 97 | Sulfoxidation | GFPRKEGMERKDVMS CCCCCCCCCHHHHHH | 4.76 | 25693801 | |
| 119 | Ubiquitination | SQAAALEKHAAPNCK HHHHHHHHHCCCCCE | 39.12 | 19292762 | |
| 173 | Phosphorylation | GQISERLSVPVSDVK HHHHHHCCCCHHHCC | 30.51 | 25561503 | |
| 177 | Phosphorylation | ERLSVPVSDVKNVII HHCCCCHHHCCEEEE | 30.53 | 19880383 | |
| 189 | Phosphorylation | VIIWGNHSSSQYPDV EEEECCCCCCCCCCC | 35.37 | 22092075 | |
| 203 | Phosphorylation | VNHAKVQTSSGEKPV CCCCEEECCCCCCCH | 28.04 | 19376835 | |
| 204 | Phosphorylation | NHAKVQTSSGEKPVR CCCEEECCCCCCCHH | 21.18 | 23111157 | |
| 205 | Phosphorylation | HAKVQTSSGEKPVRE CCEEECCCCCCCHHH | 55.12 | 19376835 | |
| 242 | Phosphorylation | IIKARKLSSALSAAS HHHHHHHHHHHHHHH | 19.32 | 30291188 | |
| 243 | Phosphorylation | IKARKLSSALSAASS HHHHHHHHHHHHHHH | 43.60 | 24601666 | |
| 246 | Phosphorylation | RKLSSALSAASSACD HHHHHHHHHHHHHCH | 22.85 | 30291188 | |
| 249 | Phosphorylation | SSALSAASSACDHIR HHHHHHHHHHCHHHH | 20.41 | 27643528 | |
| 250 | Phosphorylation | SALSAASSACDHIRD HHHHHHHHHCHHHHH | 28.34 | 27643528 | |
| 313 | Sulfoxidation | DEVSRKKMDLTAEEL HHHHHHHCCCCHHHH | 5.99 | 25693801 | |
| 316 | Phosphorylation | SRKKMDLTAEELKEE HHHHCCCCHHHHHHH | 27.97 | 19880383 | |
| 332 | Phosphorylation | DLAYSCLS------- HHHHHHCC------- | 42.37 | 29654922 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MDHC1_ARATH !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MDHC1_ARATH !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MDHC1_ARATH !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of MDHC1_ARATH !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks."; Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.; Plant Physiol. 150:889-903(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204 AND SER-205, ANDMASS SPECTROMETRY. | |
| Ubiquitylation | |
| Reference | PubMed |
| "Tandem affinity purification and mass spectrometric analysis ofubiquitylated proteins in Arabidopsis."; Saracco S.A., Hansson M., Scalf M., Walker J.M., Smith L.M.,Vierstra R.D.; Plant J. 59:344-358(2009). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-119, AND IDENTIFICATIONBY MASS SPECTROMETRY. | |
