SPT16_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPT16_ARATH
• UniProt AC: O82491
• Protein Name: FACT complex subunit SPT16
• Gene Name: SPT16
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1074
• Subcellular Localization: Nucleus . Chromosome . Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.
• Protein Description: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (Probable)..
• Protein Sequence: MADSRNGNARAPPSGVPPKAGNTYSIDVKNFISRARALYEHWKKHSADLWGSADALAIATPPASDDLRYLKSSALNIWLLGYEFPDTIMVFTKKQIHFLCSRNKASLLEVVKKPAHDELKLDVIMHVKPKGDDGTGLMDAIFRAIRDLSRGDGNDSQVVGHIAREAPEGKLLETWTERLKNANFQFVDITGGLSDLFAVKDDTEVMSVKKAAYLAYSVMKNVVVPNLESAIDEEKDVTHSALMDLTEKAILEPTKASVKLKPENVDICYPPIFQSGGKFDLKPSAASNDELLTYDPASIIICAVGARYNSYCSNVARTYLIDATSLQSKAYEVLLKAHEAAIDALRSGRKINTVYQAALSVVEKNAPEFVDKLTKSAGTGIGLEFRESGLNINAKNDKVLRPKMAFNVSLGFQNLECESESRSKNKKFSLLLADTVLVTDQKPELLTKCSKSVKDVAYSFKEDEEEEKPRKKARTSGSENYITKTALRSDDHVVSKEELRKQHQAELARQKNEETARRLAGDSSGAGDSRSTAKTSADVVAYKNVNDMPHKELMIQVDTRNEAVLLPIYGSLVPFHVATIRTVSGNQDTNRNCYIRIIFNVPGTPFNPHDSNSLKNQGAIYLKEVSFRTKDSRHSSEVTQQIKTLRRQVMARESERAERATLVTQEKLQLAGNKFKPLRLSELWIRPPFSGRKKIPGTLEAHANGFRYSTTRPDERVDVLFANIKHAFFQPAEKEMITLLHFHLHNHIMVGTKKTKDVQFYVEVMDVVQSLGGGRRSAYDPDEIDEEQRERDRKNKINMDFNHFANRVNDMWQLPQFASLDLEFDQPLRELGFHGVPHKTSAFIIPTSSCLVELIEYPFLVVSLSEIEIVNLERVGFGQKNFDMAIIFKDFKKDVLRVDSVPTSSLEGIKEWLDTTDIKYYESKLNLNWRQILKTITDDPQSFIDDGGWEFLNLDGSDSESGGSEESDKGYEPSDVEVESESEDEASESESLVESDDDEEEDSEQESEEEKGKTWDELEREATNADREHGVESDSEEERKRRKMKAFGKSRPGTSGGGGSSSMKNMPPSKRKHR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MADSRNGNARA ----CCCCCCCCCCC	34.40	19880383
238	Phosphorylation	IDEEKDVTHSALMDL CCCCCCCCHHHHHHH	21.90	19880383
240	Phosphorylation	EEKDVTHSALMDLTE CCCCCCHHHHHHHHH	17.46	19880383
1023	Phosphorylation	DELEREATNADREHG HHHHHHHHHHHHHCC	26.62	23776212
1033	Phosphorylation	DREHGVESDSEEERK HHHCCCCCCCHHHHH	43.99	23776212
1035	Phosphorylation	EHGVESDSEEERKRR HCCCCCCCHHHHHHH	57.07	23776212
1050	Phosphorylation	KMKAFGKSRPGTSGG HHHHHCCCCCCCCCC	44.05	26811356
1054	Phosphorylation	FGKSRPGTSGGGGSS HCCCCCCCCCCCCCC	27.21	26811356
1055	Phosphorylation	GKSRPGTSGGGGSSS CCCCCCCCCCCCCCC	41.16	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPT16_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPT16_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPT16_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SSRP1_ARATH	HMG	physical	15546350

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.