SSRP1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SSRP1_ARATH
• UniProt AC: Q05153
• Protein Name: FACT complex subunit SSRP1
• Gene Name: SSRP1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 646
• Subcellular Localization: Nucleus . Chromosome . Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.
• Protein Description: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to double-stranded DNA (Probable). Required for karyogamy during female gametophyte development, when the two polar nuclei fuse to form the diploid central cell nucleus. [PubMed: 16698901]
• Protein Sequence: MADGHSFNNISLSGRGGKNPGLLKINSGGIQWKKQGGGKAVEVDRSDIVSVSWTKVTKSNQLGVKTKDGLYYKFVGFRDQDVPSLSSFFQSSYGKTPDEKQLSVSGRNWGEVDLHGNTLTFLVGSKQAFEVSLADVSQTQLQGKNDVTLEFHVDDTAGANEKDSLMEISFHIPNSNTQFVGDENRPPSQVFNDTIVAMADVSPGVEDAVVTFESIAILTPRGRYNVELHLSFLRLQGQANDFKIQYSSVVRLFLLPKSNQPHTFVVISLDPPIRKGQTMYPHIVMQFETDTVVESELSISDELMNTKFKDKLERSYKGLIHEVFTTVLRWLSGAKITKPGKFRSSQDGFAVKSSLKAEDGVLYPLEKGFFFLPKPPTLILHDEIDYVEFERHAAGGANMHYFDLLIRLKTDHEHLFRNIQRNEYHNLYTFISSKGLKIMNLGGAGTADGVAAVLGDNDDDDAVDPHLTRIRNQAADESDEEDEDFVMGEDDDGGSPTDDSGGDDSDASEGGVGEIKEKSIKKEPKKEASSSKGLPPKRKTVAADEGSSKRKKPKKKKDPNAPKRAMSGFMFFSQMERDNIKKEHPGIAFGEVGKVLGDKWRQMSADDKEPYEAKAQVDKQRYKDEISDYKNPQPMNVDSGNDSDSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	PGLLKINSGGIQWKK CCCEEECCCCCEEEE	41.70	25561503
639	Phosphorylation	PQPMNVDSGNDSDSN CCCCCCCCCCCCCCC	34.90	23776212
643	Phosphorylation	NVDSGNDSDSN---- CCCCCCCCCCC----	47.11	23776212
645	Phosphorylation	DSGNDSDSN------ CCCCCCCCC------	48.68	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SSRP1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SSRP1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SSRP1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPT16_ARATH	SPT16	physical	15546350

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.