AB2B_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AB2B_ARATH
• UniProt AC: Q8LPK2
• Protein Name: ABC transporter B family member 2
• Gene Name: ABCB2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1273
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MYISLIFFLSNHFPPLISIPIFIFLSFSSPTNYTHLKLKKMQPSGDPAPEKEKEMTQPKVSLLKLFSFADFYDCVLMTLGSVGACIHGASVPIFFIFFGKLINIIGLAYLFPKQASHRVAKYSLDFVYLSVAILFSSWLEVACWMHTGERQAAKMRRAYLRSMLSQDISLFDTEASTGEVISAITSDILVVQDALSEKVGNFLHYISRFIAGFAIGFTSVWQISLVTLSIVPLIALAGGIYAFVAIGLIARVRKSYIKAGEIAEEVIGNVRTVQAFTGEERAVRLYREALENTYKYGRKAGLTKGLGLGSMHCVLFLSWALLVWFTSVVVHKDIADGGKSFTTMLNVVIAGLSLGQAAPDISAFVRAKAAAYPIFKMIERNTVTKTSAKSGRKLGKVDGHIQFKDATFSYPSRPDVVIFDRLNLAIPAGKIVALVGGSGSGKSTVISLIERFYEPISGAVLLDGNNISELDIKWLRGQIGLVNQEPALFATTIRENILYGKDDATAEEITRAAKLSEAISFINNLPEGFETQVGERGIQLSGGQKQRIAISRAIVKNPSILLLDEATSALDAESEKSVQEALDRVMVGRTTVVVAHRLSTVRNADIIAVVHEGKIVEFGNHENLISNPDGAYSSLLRLQETASLQRNPSLNRTLSRPHSIKYSRELSRTRSSFCSERESVTRPDGADPSKKVKVTVGRLYSMIRPDWMYGVCGTICAFIAGSQMPLFALGVSQALVSYYSGWDETQKEIKKIAILFCCASVITLIVYTIEHICFGTMGERLTLRVRENMFRAILKNEIGWFDEVDNTSSMLASRLESDATLLKTIVVDRSTILLQNLGLVVTSFIIAFILNWRLTLVVLATYPLVISGHISEKLFMQGYGGDLNKAYLKANMLAGESVSNIRTVAAFCAEEKILELYSRELLEPSKSSFRRGQIAGLFYGVSQFFIFSSYGLALWYGSTLMDKGLAGFKSVMKTFMVLIVTALAMGETLALAPDLLKGNQMVASVFEILDRKTQIVGETSEELNNVEGTIELKGVHFSYPSRPDVVIFRDFDLIVRAGKSMALVGQSGSGKSSVISLILRFYDPTAGKVMIEGKDIKKLDLKALRKHIGLVQQEPALFATTIYENILYGNEGASQSEVVESAMLANAHSFITSLPEGYSTKVGERGVQMSGGQRQRIAIARAILKNPAILLLDEATSALDVESERVVQQALDRLMANRTTVVVAHRLSTIKNADTISVLHGGKIVEQGSHRKLVLNKSGPYFKLISLQQQQQP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
466	N-linked_Glycosylation	AVLLDGNNISELDIK CEEECCCCCCHHHHH	44.70	-
649	Phosphorylation	ASLQRNPSLNRTLSR HHCCCCCCHHHCCCC	41.65	19376835
651	N-linked_Glycosylation	LQRNPSLNRTLSRPH CCCCCCHHHCCCCCC	38.95	-
655	Phosphorylation	PSLNRTLSRPHSIKY CCHHHCCCCCCHHHH	43.06	27531888
659	Phosphorylation	RTLSRPHSIKYSREL HCCCCCCHHHHHHHH	24.37	30300945
663	Phosphorylation	RPHSIKYSRELSRTR CCCHHHHHHHHHCCC	17.80	25561503
671	Phosphorylation	RELSRTRSSFCSERE HHHHCCCCCHHCCCC	27.44	25561503
672	Phosphorylation	ELSRTRSSFCSERES HHHCCCCCHHCCCCC	27.29	25561503
675	Phosphorylation	RTRSSFCSERESVTR CCCCCHHCCCCCCCC	37.36	25561503
806	N-linked_Glycosylation	GWFDEVDNTSSMLAS CCCCCCCCHHHHHHH	47.22	-
918	Phosphorylation	EKILELYSRELLEPS HHHHHHHHHHHHCCC	31.72	24894044
1217	N-linked_Glycosylation	ALDRLMANRTTVVVA HHHHHHCCCCEEEEE	28.06	-
1256	N-linked_Glycosylation	SHRKLVLNKSGPYFK CCEEEEEECCCCCEE	29.03	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AB2B_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AB2B_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AB2B_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of AB2B_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-649, AND MASSSPECTROMETRY.
PubMed: 19376835