RPT2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RPT2_ARATH
• UniProt AC: Q682S0
• Protein Name: Root phototropism protein 2
• Gene Name: RPT2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 593
• Protein Description: May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Signal transducer of the phototropic response and photo-induced movements. Necessary for root phototropism. Involved in hypocotyl phototropism under high rate but not under low rate light. Regulates stomata opening. Seems to be not involved in chloroplast accumulation and translocation..
• Protein Sequence: MATEGKNPINMNSMSSSLARTGQWVFSQDIPTDVVVEVGEANFSLHKFMLVAKSNYIRKLIMESKDSDVTRINLSDIPGGPEIFEKAAKFCYGVNFEITVQNVAALHCAAEFLQMTDKYCDNNLAGRTQDFLSQVALSSLSGAIVVLKSCEILLPISRDLGIVRRCVDVVGAKACNEAMFPCRTPPNWWTEELCILDVDFFSDVVSSMKQRGVKPSSLASAIITYTEKSLRDLVRDHSGRGVKYSDPGDNESDERSQQRDLVQSIVSLLPSDKGLFPVNFLCSLLRCAVFLDTSLTCKNELEKRISVVLEHVSVDDLLIPSFTYDGERLLDLDSVRRIISAFVEKEKNVGVFNGGDFNRGVCSVSLQRVAKTVDSYLAEIATYGDLTISKFNAIANLVPKSARKSDDDLYRAIDIFLKAHPNLDEIEREKVCSSMDPLKLSYDARLHASQNKRLPVNIVLHALYYDQLKLRSGVAEQEERAVVVLPEALKTRSQLQADTTLAKENEALRSELMKMKMYVSDMQKNKNGAGASSSNSSSLVSSKKSKHTFFSSVSKKLGKLNPFKNGSKDTSHIDEDLGGVDITKPRRRRFSIS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	KNPINMNSMSSSLAR CCCCCCCHHCHHHHH	14.85	23111157
15	Phosphorylation	PINMNSMSSSLARTG CCCCCHHCHHHHHHC	19.32	23111157
16	Phosphorylation	INMNSMSSSLARTGQ CCCCHHCHHHHHHCC	22.26	23111157
17	Phosphorylation	NMNSMSSSLARTGQW CCCHHCHHHHHHCCE	20.81	23111157
410	Phosphorylation	RKSDDDLYRAIDIFL CCCHHHHHHHHHHHH	12.66	-
491	Phosphorylation	VLPEALKTRSQLQAD ECHHHHHHHHHHHHC	36.08	19880383
493	Phosphorylation	PEALKTRSQLQADTT HHHHHHHHHHHHCCH	40.24	23111157
513	Sulfoxidation	EALRSELMKMKMYVS HHHHHHHHHHHHHHH	3.32	25693801
552	Phosphorylation	SKHTFFSSVSKKLGK CCCCCHHHHHHHHCC	25.83	25561503
554	Phosphorylation	HTFFSSVSKKLGKLN CCCHHHHHHHHCCCC	26.48	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RPT2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RPT2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RPT2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GMD1_ARATH	GMD1	physical	21798944

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.