dbPTM

NEDD1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NEDD1_MOUSE
UniProt AC	P33215
Protein Name	Protein NEDD1
Gene Name	Nedd1
Organism	Mus musculus (Mouse).
Sequence Length	660
Subcellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
Protein Description	Required for mitosis progression. Promotes the nucleation of microtubules from the spindle (By similarity). May play an important role during the embryonic development and differentiation of the central nervous system. [PubMed: 1378265]
Protein Sequence	MQENLRFASSGDDVKIWDASFLTLVDKFNPHTSPHGISSICWSSNNNFLVTASSSGDKIVVSSCKCKPVPLLELAEGQKQTCVDLNSTSMYLASGGLNNTVNIWDLKSKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIILHSVTTNTSSTPFGHGSKQPIRHIKYSLFRKSLLGSVSDNGVVTLWDVNSQSSYHTFDSTHKAPASGICFSPVNELLFVTIGLDKRIILYDTSSKKLVKTLVADTPLTAVDFMPDGATLAIGSSRGKIYQYDLRMLKSPVKTISAHKTSVQCIAFQYSTSLTKASLSKGSSNKATAVNKRSVPVSSSSGAAQNSGIVREAPSPSIATVLPQPVTTALGKGSGAAQDEAGLARSKSTDIFSKETDAGKSQDFSSFDDTGKNSLGDMFSPIRDDAVVSKGGDESIGKGDGLDFLPQLNSVFPLRKNAGASSSLVLHSSPLNVLMGSSGKEENESHEPSAESKRAYLGKQEPKDAMKQFTKLISSGAEPGILNTCPSSNQARNLEKFEKPEKDIEAQLIHEPSVNGSSTTVPKAASSVTAGVASSLSEKIVDTLGNSRPGAPLTSVQIRFIQNMIQETLDDFREACHRDIVNLQVEMIKQFHIQLNEMHSLLERYSVNEGLVAEIERLREENKRLRAHF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	DVKIWDASFLTLVDK CEEEEEHHHHHHHHH	20.51	26060331
23	Phosphorylation	IWDASFLTLVDKFNP EEEHHHHHHHHHCCC	23.79	28285833
282	Phosphorylation	YDLRMLKSPVKTISA EEHHHHCCCCEEECC	30.85	24719451
325	Phosphorylation	ATAVNKRSVPVSSSS CEECCCCCCCCCCCC	32.17	27566939
346	Phosphorylation	GIVREAPSPSIATVL CCCCCCCCCCCEEEC	38.02	25266776
348	Phosphorylation	VREAPSPSIATVLPQ CCCCCCCCCEEECCC	29.23	25266776
351	Phosphorylation	APSPSIATVLPQPVT CCCCCCEEECCCCCE	22.39	25777480
358	Phosphorylation	TVLPQPVTTALGKGS EECCCCCEECCCCCC	17.03	25777480
359	Phosphorylation	VLPQPVTTALGKGSG ECCCCCEECCCCCCC	21.81	25777480
377	Phosphorylation	DEAGLARSKSTDIFS CHHHHCCCCCCCCCC	25.92	28833060
379	Phosphorylation	AGLARSKSTDIFSKE HHHCCCCCCCCCCCC	32.34	25521595
380	Phosphorylation	GLARSKSTDIFSKET HHCCCCCCCCCCCCC	36.53	27742792
384	Phosphorylation	SKSTDIFSKETDAGK CCCCCCCCCCCCCCC	29.89	28833060
387	Phosphorylation	TDIFSKETDAGKSQD CCCCCCCCCCCCCCC	34.58	23684622
392	Phosphorylation	KETDAGKSQDFSSFD CCCCCCCCCCCCCCC	33.78	28464351
396	Phosphorylation	AGKSQDFSSFDDTGK CCCCCCCCCCCCCCC	38.08	25521595
397	Phosphorylation	GKSQDFSSFDDTGKN CCCCCCCCCCCCCCC	32.46	25266776
401	Phosphorylation	DFSSFDDTGKNSLGD CCCCCCCCCCCCCCC	52.48	28066266
405	Phosphorylation	FDDTGKNSLGDMFSP CCCCCCCCCCCCCCC	36.90	22817900
411	Phosphorylation	NSLGDMFSPIRDDAV CCCCCCCCCCCCCCE	16.87	26745281
420	Phosphorylation	IRDDAVVSKGGDESI CCCCCEEECCCCCCC	20.98	27742792
426	Phosphorylation	VSKGGDESIGKGDGL EECCCCCCCCCCCCC	41.19	23984901
468	Phosphorylation	PLNVLMGSSGKEENE CCHHHCCCCCCCCCC	23.19	-
483	Phosphorylation	SHEPSAESKRAYLGK CCCCCHHHHHHHHCC	27.45	23567750
487	Phosphorylation	SAESKRAYLGKQEPK CHHHHHHHHCCCCCH	21.74	29514104
550	Phosphorylation	PSVNGSSTTVPKAAS CCCCCCCCCCCCHHH	33.25	-
637	Phosphorylation	HSLLERYSVNEGLVA HHHHHHHCCCHHHHH	25.37	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
397	S	Phosphorylation	Kinase	PLK1	Q07832	Uniprot
426	S	Phosphorylation	Kinase	PLK1	Q07832	Uniprot
550	T	Phosphorylation	Kinase	CDK1	P11440	Uniprot
637	S	Phosphorylation	Kinase	PLK1	Q07832	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
397	S	Phosphorylation	-
During mitosis, prior phosphorylation on Thr-550 by CDK1 promotes subsequent phosphorylation by PLK1 on Ser-397, Ser-426 and Ser-637.
426	S	Phosphorylation	-
During mitosis, prior phosphorylation on Thr-550 by CDK1 promotes subsequent phosphorylation by PLK1 on Ser-397, Ser-426 and Ser-637.
550	T	Phosphorylation	-
During mitosis, prior phosphorylation on Thr-550 by CDK1 promotes subsequent phosphorylation by PLK1 on Ser-397, Ser-426 and Ser-637.
637	S	Phosphorylation	-
During mitosis, prior phosphorylation on Thr-550 by CDK1 promotes subsequent phosphorylation by PLK1 on Ser-397, Ser-426 and Ser-637.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NEDD1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SET_HUMAN	SET	physical	20360068
NEDD1_HUMAN	NEDD1	physical	20360068
ACV1B_HUMAN	ACVR1B	physical	26496610
ATM_HUMAN	ATM	physical	26496610
CFAB_HUMAN	CFB	physical	26496610
TCPZ_HUMAN	CCT6A	physical	26496610
DHC24_HUMAN	DHCR24	physical	26496610
ECHM_HUMAN	ECHS1	physical	26496610
IF5A1_HUMAN	EIF5A	physical	26496610
DHB4_HUMAN	HSD17B4	physical	26496610
NP1L4_HUMAN	NAP1L4	physical	26496610
NDUV3_HUMAN	NDUFV3	physical	26496610
PCM1_HUMAN	PCM1	physical	26496610
TRY1_HUMAN	PRSS1	physical	26496610
TRY3_HUMAN	PRSS3	physical	26496610
TRI27_HUMAN	TRIM27	physical	26496610
S10A4_HUMAN	S100A4	physical	26496610
S10A6_HUMAN	S100A6	physical	26496610
TCPA_HUMAN	TCP1	physical	26496610
TPD52_HUMAN	TPD52	physical	26496610
TCPG_HUMAN	CCT3	physical	26496610
TBG1_HUMAN	TUBG1	physical	26496610
THIO_HUMAN	TXN	physical	26496610
RT29_HUMAN	DAP3	physical	26496610
AK17A_HUMAN	AKAP17A	physical	26496610
USP9X_HUMAN	USP9X	physical	26496610
TRADD_HUMAN	TRADD	physical	26496610
GUAA_HUMAN	GMPS	physical	26496610
BCL10_HUMAN	BCL10	physical	26496610
TOP3B_HUMAN	TOP3B	physical	26496610
MOT4_HUMAN	SLC16A3	physical	26496610
CP110_HUMAN	CCP110	physical	26496610
MLEC_HUMAN	MLEC	physical	26496610
ARHGB_HUMAN	ARHGEF11	physical	26496610
MOONR_HUMAN	KIAA0753	physical	26496610
ACOT8_HUMAN	ACOT8	physical	26496610
PDCD6_HUMAN	PDCD6	physical	26496610
INADL_HUMAN	INADL	physical	26496610
GCP3_HUMAN	TUBGCP3	physical	26496610
PIBF1_HUMAN	PIBF1	physical	26496610
HNRPQ_HUMAN	SYNCRIP	physical	26496610
TCPH_HUMAN	CCT7	physical	26496610
TCPD_HUMAN	CCT4	physical	26496610
TCPB_HUMAN	CCT2	physical	26496610
CELF2_HUMAN	CELF2	physical	26496610
CGRF1_HUMAN	CGRRF1	physical	26496610
TCPQ_HUMAN	CCT8	physical	26496610
GCP2_HUMAN	TUBGCP2	physical	26496610
BAZ1A_HUMAN	BAZ1A	physical	26496610
RRAS2_HUMAN	RRAS2	physical	26496610
DHX30_HUMAN	DHX30	physical	26496610
TCPE_HUMAN	CCT5	physical	26496610
CP131_HUMAN	CEP131	physical	26496610
PALLD_HUMAN	PALLD	physical	26496610
ZC3HD_HUMAN	ZC3H13	physical	26496610
DNMBP_HUMAN	DNMBP	physical	26496610
FBXL4_HUMAN	FBXL4	physical	26496610
NARF_HUMAN	NARF	physical	26496610
GCP4_HUMAN	TUBGCP4	physical	26496610
NDK7_HUMAN	NME7	physical	26496610
CHMP3_HUMAN	CHMP3	physical	26496610
GAR1_HUMAN	GAR1	physical	26496610
PALMD_HUMAN	PALMD	physical	26496610
MSTO1_HUMAN	MSTO1	physical	26496610
SMU1_HUMAN	SMU1	physical	26496610
M18BP_HUMAN	MIS18BP1	physical	26496610
PLXA3_HUMAN	PLXNA3	physical	26496610
HAUS7_HUMAN	HAUS7	physical	26496610
PR40A_HUMAN	PRPF40A	physical	26496610
CEP72_HUMAN	CEP72	physical	26496610
FGD6_HUMAN	FGD6	physical	26496610
BDP1_HUMAN	BDP1	physical	26496610
CAND1_HUMAN	CAND1	physical	26496610
RCC2_HUMAN	RCC2	physical	26496610
AK1BA_HUMAN	AKR1B10	physical	26496610
Z286A_HUMAN	ZNF286A	physical	26496610
MIB1_HUMAN	MIB1	physical	26496610
WDR35_HUMAN	WDR35	physical	26496610
BRCC3_HUMAN	BRCC3	physical	26496610
CEP97_HUMAN	CEP97	physical	26496610
EFL1_HUMAN	EFTUD1	physical	26496610
DYHC2_HUMAN	DYNC2H1	physical	26496610
DHX40_HUMAN	DHX40	physical	26496610
CJ088_HUMAN	C10orf88	physical	26496610
CE290_HUMAN	CEP290	physical	26496610
GRPE1_HUMAN	GRPEL1	physical	26496610
TRUA_HUMAN	PUS1	physical	26496610
ZFP91_HUMAN	ZFP91	physical	26496610
MED10_HUMAN	MED10	physical	26496610
CCD77_HUMAN	CCDC77	physical	26496610
LZIC_HUMAN	LZIC	physical	26496610
HOOK3_HUMAN	HOOK3	physical	26496610
FBH1_HUMAN	FBXO18	physical	26496610
GCP6_HUMAN	TUBGCP6	physical	26496610
ACBD5_HUMAN	ACBD5	physical	26496610
GCP5_HUMAN	TUBGCP5	physical	26496610
ADIP_HUMAN	SSX2IP	physical	26496610
ALKB2_HUMAN	ALKBH2	physical	26496610
FOPNL_HUMAN	FOPNL	physical	26496610
RBM45_HUMAN	RBM45	physical	26496610
SGO1_HUMAN	SGOL1	physical	26496610
VP13B_HUMAN	VPS13B	physical	26496610
SNX33_HUMAN	SNX33	physical	26496610
MZT2A_HUMAN	MZT2A	physical	26496610
CCD61_HUMAN	CCDC61	physical	26496610

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NEDD1_MOUSE

Related Literatures of Post-Translational Modification

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