dbPTM

BMR1A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BMR1A_MOUSE
UniProt AC	P36895
Protein Name	Bone morphogenetic protein receptor type-1A
Gene Name	Bmpr1a
Organism	Mus musculus (Mouse).
Sequence Length	532
Subcellular Localization	Membrane Single-pass type I membrane protein.
Protein Description	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. [PubMed: 24098149 Mediates induction of adipogenesis by GDF6]
Protein Sequence	MTQLYTYIRLLGACLFIISHVQGQNLDSMLHGTGMKSDLDQKKPENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLTSGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVVLISMAVCIVAMIIFSSCFCYKHYCKSISSRGRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDIPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	GACLFIISHVQGQNL HHHHHHHHHHCCCCH	16.88	-
73	N-linked_Glycosylation	HCPDDAINNTCITNG CCCCCHHCCCEEECC	39.21	-
232	Ubiquitination	LVQRTIAKQIQMVRQ HHHHHHHHHHHHHHH	44.05	22790023
453	Phosphorylation	TGGIVEEYQLPYYNM HCCHHEEEECCCCCC	11.22	22729085
457	Phosphorylation	VEEYQLPYYNMVPSD HEEEECCCCCCCCCC	18.96	22729085
458	Phosphorylation	EEYQLPYYNMVPSDP EEEECCCCCCCCCCC	8.54	22729085
467	Phosphorylation	MVPSDPSYEDMREVV CCCCCCCHHHHHHHE	22.72	22729085
523	Ubiquitination	RIKKTLAKMVESQDV HHHHHHHHHHHCCCC	46.74	22790023
527	Phosphorylation	TLAKMVESQDVKI-- HHHHHHHCCCCCC--	21.92	21659604

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
453	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
453	Y	Phosphorylation	Kinase	ABL	P00520	PSP
457	Y	Phosphorylation	Kinase	ABL	P00519	PSP
457	Y	Phosphorylation	Kinase	ABL	P00520	PSP
458	Y	Phosphorylation	Kinase	ABL	P00519	PSP
458	Y	Phosphorylation	Kinase	ABL	P00520	PSP
467	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
467	Y	Phosphorylation	Kinase	ABL	P00520	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BMR1A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BMR1A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTNB1_MOUSE	Ctnnb1	genetic	20043884
BMR1A_HUMAN	BMPR1A	physical	20360068
ANXA1_HUMAN	ANXA1	physical	26496610
AT1A1_HUMAN	ATP1A1	physical	26496610
AT2B1_HUMAN	ATP2B1	physical	26496610
ATPA_HUMAN	ATP5A1	physical	26496610
VATA_HUMAN	ATP6V1A	physical	26496610
VATB2_HUMAN	ATP6V1B2	physical	26496610
VPP1_HUMAN	ATP6V0A1	physical	26496610
VAS1_HUMAN	ATP6AP1	physical	26496610
AUP1_HUMAN	AUP1	physical	26496610
BST2_HUMAN	BST2	physical	26496610
CAV1_HUMAN	CAV1	physical	26496610
CD44_HUMAN	CD44	physical	26496610
CLCN7_HUMAN	CLCN7	physical	26496610
CBPM_HUMAN	CPM	physical	26496610
CTNA1_HUMAN	CTNNA1	physical	26496610
DHCR7_HUMAN	DHCR7	physical	26496610
DSG2_HUMAN	DSG2	physical	26496610
EGFR_HUMAN	EGFR	physical	26496610
EMD_HUMAN	EMD	physical	26496610
STOM_HUMAN	STOM	physical	26496610
ETFB_HUMAN	ETFB	physical	26496610
FLOT2_HUMAN	FLOT2	physical	26496610
G3P_HUMAN	GAPDH	physical	26496610
PUR2_HUMAN	GART	physical	26496610
DHE3_HUMAN	GLUD1	physical	26496610
GBB2_HUMAN	GNB2	physical	26496610
HSPB1_HUMAN	HSPB1	physical	26496610
HS90A_HUMAN	HSP90AA1	physical	26496610
HS90B_HUMAN	HSP90AB1	physical	26496610
IMDH2_HUMAN	IMPDH2	physical	26496610
JAK1_HUMAN	JAK1	physical	26496610
PLAK_HUMAN	JUP	physical	26496610
LIFR_HUMAN	LIFR	physical	26496610
TNR3_HUMAN	LTBR	physical	26496610
NDUA7_HUMAN	NDUFA7	physical	26496610
NDUB4_HUMAN	NDUFB4	physical	26496610
NDUS1_HUMAN	NDUFS1	physical	26496610
NDUV1_HUMAN	NDUFV1	physical	26496610
NDUS5_HUMAN	NDUFS5	physical	26496610
NOTC2_HUMAN	NOTCH2	physical	26496610
PHB_HUMAN	PHB	physical	26496610
PPIA_HUMAN	PPIA	physical	26496610
ABCD3_HUMAN	ABCD3	physical	26496610
RAB1A_HUMAN	RAB1A	physical	26496610
RCN1_HUMAN	RCN1	physical	26496610
RNF5_HUMAN	RNF5	physical	26496610
GTR1_HUMAN	SLC2A1	physical	26496610
S12A2_HUMAN	SLC12A2	physical	26496610
S12A3_HUMAN	SLC12A3	physical	26496610
MOT1_HUMAN	SLC16A1	physical	26496610
SYUG_HUMAN	SNCG	physical	26496610
FSCN1_HUMAN	FSCN1	physical	26496610
SOAT1_HUMAN	SOAT1	physical	26496610
TAP1_HUMAN	TAP1	physical	26496610
TFR1_HUMAN	TFRC	physical	26496610
ENPL_HUMAN	HSP90B1	physical	26496610
QCR1_HUMAN	UQCRC1	physical	26496610
YES_HUMAN	YES1	physical	26496610
ZSC21_HUMAN	ZSCAN21	physical	26496610
ZNT1_HUMAN	SLC30A1	physical	26496610
RAB7A_HUMAN	RAB7A	physical	26496610
NCOA4_HUMAN	NCOA4	physical	26496610
TR10B_HUMAN	TNFRSF10B	physical	26496610
RAI3_HUMAN	GPRC5A	physical	26496610
VA0D1_HUMAN	ATP6V0D1	physical	26496610
OSMR_HUMAN	OSMR	physical	26496610
XPR1_HUMAN	XPR1	physical	26496610
VAPB_HUMAN	VAPB	physical	26496610
RAB9A_HUMAN	RAB9A	physical	26496610
S4A7_HUMAN	SLC4A7	physical	26496610
GOSR1_HUMAN	GOSR1	physical	26496610
PDIA4_HUMAN	PDIA4	physical	26496610
IST1_HUMAN	IST1	physical	26496610
BRE1B_HUMAN	RNF40	physical	26496610
LGAT1_HUMAN	LPGAT1	physical	26496610
ABCB6_HUMAN	ABCB6	physical	26496610
FLOT1_HUMAN	FLOT1	physical	26496610
CHIP_HUMAN	STUB1	physical	26496610
BASP1_HUMAN	BASP1	physical	26496610
HAX1_HUMAN	HAX1	physical	26496610
HYOU1_HUMAN	HYOU1	physical	26496610
SPTC1_HUMAN	SPTLC1	physical	26496610
ERLN1_HUMAN	ERLIN1	physical	26496610
AFG32_HUMAN	AFG3L2	physical	26496610
CKAP4_HUMAN	CKAP4	physical	26496610
GCN1_HUMAN	GCN1L1	physical	26496610
MIC60_HUMAN	IMMT	physical	26496610
WWP2_HUMAN	WWP2	physical	26496610
ERLN2_HUMAN	ERLIN2	physical	26496610
PDXD1_HUMAN	PDXDC1	physical	26496610
FAF2_HUMAN	FAF2	physical	26496610
FKBP8_HUMAN	FKBP8	physical	26496610
CHM2B_HUMAN	CHMP2B	physical	26496610
LRP10_HUMAN	LRP10	physical	26496610
PKHG3_HUMAN	PLEKHG3	physical	26496610
TOIP1_HUMAN	TOR1AIP1	physical	26496610
SERA_HUMAN	PHGDH	physical	26496610
MYOF_HUMAN	MYOF	physical	26496610
PACN3_HUMAN	PACSIN3	physical	26496610
STML2_HUMAN	STOML2	physical	26496610
LSR_HUMAN	LSR	physical	26496610
S38A2_HUMAN	SLC38A2	physical	26496610
RMD3_HUMAN	RMDN3	physical	26496610
RIF1_HUMAN	RIF1	physical	26496610
NDC1_HUMAN	NDC1	physical	26496610
NDUAC_HUMAN	NDUFA12	physical	26496610
GBG12_HUMAN	GNG12	physical	26496610
S39AA_HUMAN	SLC39A10	physical	26496610
KDIS_HUMAN	KIDINS220	physical	26496610
SQOR_HUMAN	SQRDL	physical	26496610
SRPRB_HUMAN	SRPRB	physical	26496610
FAKD5_HUMAN	FASTKD5	physical	26496610
TM237_HUMAN	TMEM237	physical	26496610
AHNK_HUMAN	AHNAK	physical	26496610
MBOA7_HUMAN	MBOAT7	physical	26496610
TMM43_HUMAN	TMEM43	physical	26496610
CYBR1_HUMAN	CYBRD1	physical	26496610
ERMP1_HUMAN	ERMP1	physical	26496610
T120A_HUMAN	TMEM120A	physical	26496610
MIC25_HUMAN	CHCHD6	physical	26496610
CC115_HUMAN	CCDC115	physical	26496610
ATAD1_HUMAN	ATAD1	physical	26496610
ANM9_HUMAN	PRMT9	physical	26496610
TIM50_HUMAN	TIMM50	physical	26496610
CAVN3_HUMAN	PRKCDBP	physical	26496610
CHM4B_HUMAN	CHMP4B	physical	26496610
MITD1_HUMAN	MITD1	physical	26496610
CD109_HUMAN	CD109	physical	26496610
AR6P6_HUMAN	ARL6IP6	physical	26496610
ESCO2_HUMAN	ESCO2	physical	26496610
CAVN1_HUMAN	PTRF	physical	26496610
RABL3_HUMAN	RABL3	physical	26496610
AT11C_HUMAN	ATP11C	physical	26496610
S35B2_HUMAN	SLC35B2	physical	26496610
1A02_HUMAN	HLA-A	physical	26496610
1A03_HUMAN	HLA-A	physical	26496610
1A01_HUMAN	HLA-A	physical	26496610
1A26_HUMAN	HLA-A	physical	26496610
1C07_HUMAN	HLA-C	physical	26496610

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BMR1A_MOUSE

Related Literatures of Post-Translational Modification