dbPTM

OSMR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	OSMR_HUMAN
UniProt AC	Q99650
Protein Name	Oncostatin-M-specific receptor subunit beta
Gene Name	OSMR
Organism	Homo sapiens (Human).
Sequence Length	979
Subcellular Localization	Membrane Single-pass type I membrane protein .
Protein Description	Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events..
Protein Sequence	MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYHQELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDDAKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCYLEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEPKDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQDSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRNNFTYLCQIELHGEGKMMQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWSGQNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSSSELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGTEGGFSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFRIYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYHVYLKSKARQCHPRFEKAVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTSAGEGPSATFTKVTTPDEHSSMLIHILLPMVFCVLLIMVMCYLKSQWIKETCYPDIPDPYKSSILSLIKFKENPHLIIMNVSDCIPDAIEVVSKPEGTKIQFLGTRKSLTETELTKPNYLYLLPTEKNHSGPGPCICFENLTYNQAASDSGSCGHVPVSPKAPSMLGLMTSPENVLKALEKNYMNSLGEIPAGETSLNYVSQLASPMFGDKDSLPTNPVEAPHCSEYKMQMAVSLRLALPPPTENSSLSSITLLDPGEHYC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	LAERLPLTPVSLKVS HHHHCCCCCEEEEEE	21.50	-
115	Ubiquitination	ATHFVRIKSLVDDAK HHEEEEHHHHHCCCC	27.46	29967540
163	N-linked_Glycosylation	KLVEEGTNVTICYVS HEEECCCCEEEEEEC	39.53	UniProtKB CARBOHYD
168	Phosphorylation	GTNVTICYVSRNIQN CCCEEEEEECCCCCC	9.52	22817900
180	Phosphorylation	IQNNVSCYLEGKQIH CCCCEEEEECCCEEC	10.57	22817900
209	Ubiquitination	SVPFIRNKGTNIYCE CCCCCCCCCCCEEEE	58.21	21963094
241	Ubiquitination	SKVLEEPKDFSCETE EHHCCCCCCCCCCCC	74.76	29967540
251	Ubiquitination	SCETEDFKTLHCTWD CCCCCCCCEEEEEEC	63.60	21963094
269	Ubiquitination	DTALGWSKQPSQSYT CCCCCCCCCCCCCEE	60.77	21963094
285	Ubiquitination	FESFSGEKKLCTHKN EECCCCCCEECCCCC	55.35	29967540
320	Phosphorylation	ENYLRKRSVNILFNL EHHHHHCCEEEEEEC	23.66	20068231
326	N-linked_Glycosylation	RSVNILFNLTHRVYL CCEEEEEECCCEEEE	40.35	UniProtKB CARBOHYD
379	Phosphorylation	GEGKMMQYNVSIKVN CCCCEEEEEEEEEEC	10.31	20068231
380	N-linked_Glycosylation	EGKMMQYNVSIKVNG CCCEEEEEEEEEECC	12.27	UniProtKB CARBOHYD
382	Phosphorylation	KMMQYNVSIKVNGEY CEEEEEEEEEECCEE	17.04	20068231
389	Phosphorylation	SIKVNGEYFLSELEP EEEECCEEEHHCCCC	15.95	21214269
446	N-linked_Glycosylation	IVSLEPGNHTVTLFW EEECCCCCEEEEEEE	38.07	UniProtKB CARBOHYD
455	Ubiquitination	TVTLFWKPLSKLHAN EEEEEEEEHHHHHCC	32.25	23000965
457	Ubiquitination	TLFWKPLSKLHANGK EEEEEEHHHHHCCCE	41.52	23000965
502	Ubiquitination	LILDRCSYQICVIAN EEHCCCCEEEEEEEC	12.91	23000965
563	Ubiquitination	GYVVDWCDHTQDVLG EEEEECCCCCCHHHC	43.55	23503661
567	Ubiquitination	DWCDHTQDVLGDFQW ECCCCCCHHHCCEEE	38.47	23503661
580	N-linked_Glycosylation	QWKNVGPNTTSTVIS EEEECCCCCCEEEEE	50.49	UniProtKB CARBOHYD
602	Phosphorylation	VRYDFRIYGLSTKRI CCEEEEEECCCHHHE	14.04	20068231
605	Phosphorylation	DFRIYGLSTKRIACL EEEEECCCHHHEEHH	27.76	20068231
606	Phosphorylation	FRIYGLSTKRIACLL EEEECCCHHHEEHHH	29.41	20068231
615	Ubiquitination	RIACLLEKKTGYSQE HEEHHHHCCCCCCCC	56.45	29967540
616	Ubiquitination	IACLLEKKTGYSQEL EEHHHHCCCCCCCCC	37.49	29967540
677	Ubiquitination	QCHPRFEKAVLSDGS HCCCCHHHHHCCCCC	40.87	29967540
678	Ubiquitination	CHPRFEKAVLSDGSE CCCCHHHHHCCCCCC	10.57	29967540
688	Ubiquitination	SDGSECCKYKIDNPE CCCCCEEEEECCCHH	62.33	29967540
689	Phosphorylation	DGSECCKYKIDNPEE CCCCEEEEECCCHHH	10.16	22817900
689	Ubiquitination	DGSECCKYKIDNPEE CCCCEEEEECCCHHH	10.16	29967540
710	Phosphorylation	NLKPESFYEFFITPF CCCHHHHEEEEEECC	22.55	23403867
725	Phosphorylation	TSAGEGPSATFTKVT CCCCCCCCCEEEECC	51.28	23403867
727	Phosphorylation	AGEGPSATFTKVTTP CCCCCCCEEEECCCC	35.85	23403867
729	Phosphorylation	EGPSATFTKVTTPDE CCCCCEEEECCCCCH	21.91	23403867
767	Ubiquitination	YLKSQWIKETCYPDI HHHHHHHHHHCCCCC	43.97	33845483
768	Ubiquitination	LKSQWIKETCYPDIP HHHHHHHHHCCCCCC	34.67	33845483
771	Phosphorylation	QWIKETCYPDIPDPY HHHHHHCCCCCCCCC	16.03	22468782
779	Ubiquitination	PDIPDPYKSSILSLI CCCCCCCHHHHHHHH	43.02	33845483
780	Ubiquitination	DIPDPYKSSILSLIK CCCCCCHHHHHHHHC	19.43	33845483
780	Phosphorylation	DIPDPYKSSILSLIK CCCCCCHHHHHHHHC	19.43	22468782
781	Phosphorylation	IPDPYKSSILSLIKF CCCCCHHHHHHHHCC	24.32	22468782
784	Phosphorylation	PYKSSILSLIKFKEN CCHHHHHHHHCCCCC	26.78	21815630
787	Ubiquitination	SSILSLIKFKENPHL HHHHHHHCCCCCCCE	56.53	23000965
787 (in isoform 1)	Ubiquitination	-	56.53	21890473
788	Ubiquitination	SILSLIKFKENPHLI HHHHHHCCCCCCCEE	10.73	23000965
789	Ubiquitination	ILSLIKFKENPHLII HHHHHCCCCCCCEEE	52.13	29901268
790	Ubiquitination	LSLIKFKENPHLIIM HHHHCCCCCCCEEEE	78.21	29901268
800	Phosphorylation	HLIIMNVSDCIPDAI CEEEEEHHHHCCCCE	23.04	25159151
812	Ubiquitination	DAIEVVSKPEGTKIQ CCEEEECCCCCCEEE	35.16	29901268
813	Ubiquitination	AIEVVSKPEGTKIQF CEEEECCCCCCEEEE	37.43	29901268
817	Ubiquitination	VSKPEGTKIQFLGTR ECCCCCCEEEEEECC	45.42	29967540
818	Ubiquitination	SKPEGTKIQFLGTRK CCCCCCEEEEEECCC	3.34	29967540
825	Ubiquitination	IQFLGTRKSLTETEL EEEEECCCCCCCCCC	50.05	33845483
826	Phosphorylation	QFLGTRKSLTETELT EEEECCCCCCCCCCC	36.91	21945579
826	Ubiquitination	QFLGTRKSLTETELT EEEECCCCCCCCCCC	36.91	33845483
828	Phosphorylation	LGTRKSLTETELTKP EECCCCCCCCCCCCC	48.21	21945579
830	Phosphorylation	TRKSLTETELTKPNY CCCCCCCCCCCCCCE	30.93	21945579
833	Phosphorylation	SLTETELTKPNYLYL CCCCCCCCCCCEEEE	37.92	21945579
834	Ubiquitination	LTETELTKPNYLYLL CCCCCCCCCCEEEEE	43.84	23000965
834 (in isoform 1)	Ubiquitination	-	43.84	21890473
835	Ubiquitination	TETELTKPNYLYLLP CCCCCCCCCEEEEEC	29.48	23000965
837	Phosphorylation	TELTKPNYLYLLPTE CCCCCCCEEEEECCC	12.78	21945579
839	Phosphorylation	LTKPNYLYLLPTEKN CCCCCEEEEECCCCC	8.88	21945579
843	Phosphorylation	NYLYLLPTEKNHSGP CEEEEECCCCCCCCC	60.61	21945579
845	Ubiquitination	LYLLPTEKNHSGPGP EEEECCCCCCCCCCC	63.54	29967540
846	Ubiquitination	YLLPTEKNHSGPGPC EEECCCCCCCCCCCE	28.46	29967540
848	Phosphorylation	LPTEKNHSGPGPCIC ECCCCCCCCCCCEEE	56.95	21945579
860	Phosphorylation	CICFENLTYNQAASD EEEEECCCCCCCCCC	31.82	21945579
861	Phosphorylation	ICFENLTYNQAASDS EEEECCCCCCCCCCC	14.40	21945579
866	Phosphorylation	LTYNQAASDSGSCGH CCCCCCCCCCCCCCC	35.01	21945579
868	Phosphorylation	YNQAASDSGSCGHVP CCCCCCCCCCCCCCC	30.06	21945579
870	Phosphorylation	QAASDSGSCGHVPVS CCCCCCCCCCCCCCC	22.37	21945579
877	Phosphorylation	SCGHVPVSPKAPSML CCCCCCCCCCCCHHH	18.02	21945579
879	Ubiquitination	GHVPVSPKAPSMLGL CCCCCCCCCCHHHCC	66.48	29967540
880	Ubiquitination	HVPVSPKAPSMLGLM CCCCCCCCCHHHCCC	12.56	29967540
882	O-linked_Glycosylation	PVSPKAPSMLGLMTS CCCCCCCHHHCCCCC	31.34	29351928
882	Phosphorylation	PVSPKAPSMLGLMTS CCCCCCCHHHCCCCC	31.34	29514088
888	Phosphorylation	PSMLGLMTSPENVLK CHHHCCCCCHHHHHH	46.29	22199227
889	Phosphorylation	SMLGLMTSPENVLKA HHHCCCCCHHHHHHH	19.09	25159151
895	Ubiquitination	TSPENVLKALEKNYM CCHHHHHHHHHHHHH	46.79	23503661
896	Ubiquitination	SPENVLKALEKNYMN CHHHHHHHHHHHHHH	19.45	23503661
899	Ubiquitination	NVLKALEKNYMNSLG HHHHHHHHHHHHCCC	54.98	23503661
900	Ubiquitination	VLKALEKNYMNSLGE HHHHHHHHHHHCCCC	31.73	23503661
901	Phosphorylation	LKALEKNYMNSLGEI HHHHHHHHHHCCCCC	14.56	22817900
913	Phosphorylation	GEIPAGETSLNYVSQ CCCCCCCCHHHHHHH	37.28	29523821
914	Phosphorylation	EIPAGETSLNYVSQL CCCCCCCHHHHHHHH	15.43	29523821
917	Phosphorylation	AGETSLNYVSQLASP CCCCHHHHHHHHCCC	13.53	26356563
919	Phosphorylation	ETSLNYVSQLASPMF CCHHHHHHHHCCCCC	14.76	29523821
923	Phosphorylation	NYVSQLASPMFGDKD HHHHHHCCCCCCCCC	26.03	29523821
929	Ubiquitination	ASPMFGDKDSLPTNP CCCCCCCCCCCCCCC	49.98	29967540
930	Ubiquitination	SPMFGDKDSLPTNPV CCCCCCCCCCCCCCC	61.21	29967540
931	Phosphorylation	PMFGDKDSLPTNPVE CCCCCCCCCCCCCCC	41.82	26356563
934	Phosphorylation	GDKDSLPTNPVEAPH CCCCCCCCCCCCCCC	58.40	26356563
943	Phosphorylation	PVEAPHCSEYKMQMA CCCCCCCCHHHCHHE	40.71	25627689
945	Phosphorylation	EAPHCSEYKMQMAVS CCCCCCHHHCHHEEE	8.75	27259358
952	Phosphorylation	YKMQMAVSLRLALPP HHCHHEEEEEECCCC	9.76	26270265
961	Phosphorylation	RLALPPPTENSSLSS EECCCCCCCCCCCCC	54.28	26356563
964	Phosphorylation	LPPPTENSSLSSITL CCCCCCCCCCCCEEE	26.82	26356563
965	Phosphorylation	PPPTENSSLSSITLL CCCCCCCCCCCEEEE	43.80	26356563
967	Phosphorylation	PTENSSLSSITLLDP CCCCCCCCCEEEECC	22.95	26356563
968	Phosphorylation	TENSSLSSITLLDPG CCCCCCCCEEEECCC	25.53	26356563
970	Phosphorylation	NSSLSSITLLDPGEH CCCCCCEEEECCCCC	24.18	26356563
978	Phosphorylation	LLDPGEHYC------ EECCCCCCC------	100.00	25884760

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of OSMR_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of OSMR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of OSMR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ERBB2_HUMAN	ERBB2	physical	11821958
ERBB2_HUMAN	ERBB2	physical	25241761
EGFR_HUMAN	EGFR	physical	27110918
ONCM_HUMAN	OSM	physical	17028186
JAK1_HUMAN	JAK1	physical	28514442
ANKL2_HUMAN	ANKLE2	physical	28514442

Drug and Disease Associations

Kegg Disease
H01217	Primary localized cutaneous amyloidosis (PLCA)
OMIM Disease
105250	Amyloidosis, primary localized cutaneous, 1 (PLCA1)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of OSMR_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-826 AND SER-889, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-837, AND MASSSPECTROMETRY.	18083107 [Abstract]