dbPTM

C3AR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	C3AR_HUMAN
UniProt AC	Q16581
Protein Name	C3a anaphylatoxin chemotactic receptor
Gene Name	C3AR1
Organism	Homo sapiens (Human).
Sequence Length	482
Subcellular Localization	Cell membrane Multi-pass membrane protein.
Protein Description	Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production..
Protein Sequence	MASFSAETNSTDLLSQPWNEPPVILSMVILSLTFLLGLPGNGLVLWVAGLKMQRTVNTIWFLHLTLADLLCCLSLPFSLAHLALQGQWPYGRFLCKLIPSIIVLNMFASVFLLTAISLDRCLVVFKPIWCQNHRNVGMACSICGCIWVVAFVMCIPVFVYREIFTTDNHNRCGYKFGLSSSLDYPDFYGDPLENRSLENIVQPPGEMNDRLDPSSFQTNDHPWTVPTVFQPQTFQRPSADSLPRGSARLTSQNLYSNVFKPADVVSPKIPSGFPIEDHETSPLDNSDAFLSTHLKLFPSASSNSFYESELPQGFQDYYNLGQFTDDDQVPTPLVAITITRLVVGFLLPSVIMIACYSFIVFRMQRGRFAKSQSKTFRVAVVVVAVFLVCWTPYHIFGVLSLLTDPETPLGKTLMSWDHVCIALASANSCFNPFLYALLGKDFRKKARQSIQGILEAAFSEELTRSTHCPSNNVISERNSTTV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	N-linked_Glycosylation	ASFSAETNSTDLLSQ CCCCCCCCCCCCCCC	34.12	UniProtKB CARBOHYD
174	Sulfation	DNHNRCGYKFGLSSS CCCCCCCCCCCCCCC	13.53	-
174	Sulfation	DNHNRCGYKFGLSSS CCCCCCCCCCCCCCC	13.53	12871936
184	Sulfation	GLSSSLDYPDFYGDP CCCCCCCCCCCCCCC	15.25	-
184	Sulfation	GLSSSLDYPDFYGDP CCCCCCCCCCCCCCC	15.25	12871936
194	N-linked_Glycosylation	FYGDPLENRSLENIV CCCCCCCCCCHHHCC	46.66	UniProtKB CARBOHYD
215	Phosphorylation	NDRLDPSSFQTNDHP CCCCCHHHCCCCCCC	27.11	22210691
218	Phosphorylation	LDPSSFQTNDHPWTV CCHHHCCCCCCCCCC	40.37	22210691
233	O-linked_Glycosylation	PTVFQPQTFQRPSAD CCCCCCCCCCCCCCC	28.55	OGP
238	O-linked_Glycosylation	PQTFQRPSADSLPRG CCCCCCCCCCCCCCC	47.07	OGP
250	Phosphorylation	PRGSARLTSQNLYSN CCCCCCCCCCCCHHC	23.78	22673903
251	Phosphorylation	RGSARLTSQNLYSNV CCCCCCCCCCCHHCC	22.97	22673903
255	Phosphorylation	RLTSQNLYSNVFKPA CCCCCCCHHCCCCHH	13.02	22673903
256	Phosphorylation	LTSQNLYSNVFKPAD CCCCCCHHCCCCHHH	29.68	22673903
266	O-linked_Glycosylation	FKPADVVSPKIPSGF CCHHHCCCCCCCCCC	21.96	23234360
266	Phosphorylation	FKPADVVSPKIPSGF CCHHHCCCCCCCCCC	21.96	24719451
318	Sulfation	PQGFQDYYNLGQFTD CCCCHHHHCCCCCCC	16.52	12871936
318	Sulfation	PQGFQDYYNLGQFTD CCCCHHHHCCCCCCC	16.52	-
349	Phosphorylation	VVGFLLPSVIMIACY HHHHHHHHHHHHHHH	25.01	-
459	Phosphorylation	GILEAAFSEELTRST HHHHHHHCHHHHHCC	25.99	26657352
463	Phosphorylation	AAFSEELTRSTHCPS HHHCHHHHHCCCCCC	26.34	29691806
465	Phosphorylation	FSEELTRSTHCPSNN HCHHHHHCCCCCCCC	19.78	23312004
466	Phosphorylation	SEELTRSTHCPSNNV CHHHHHCCCCCCCCC	24.98	23312004
470	Phosphorylation	TRSTHCPSNNVISER HHCCCCCCCCCCCCC	46.56	28857561
475	Phosphorylation	CPSNNVISERNSTTV CCCCCCCCCCCCCCC	26.65	28857561
479	Phosphorylation	NVISERNSTTV---- CCCCCCCCCCC----	31.51	24670416
480	Phosphorylation	VISERNSTTV----- CCCCCCCCCC-----	34.82	28857561
481	Phosphorylation	ISERNSTTV------ CCCCCCCCC------	24.84	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of C3AR_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of C3AR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of C3AR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RDH14_HUMAN	RDH14	physical	28514442
PTN2_HUMAN	PTPN2	physical	28514442
PEX13_HUMAN	PEX13	physical	28514442
VEZA_HUMAN	VEZT	physical	28514442
GOGA5_HUMAN	GOLGA5	physical	28514442
ELOV2_HUMAN	ELOVL2	physical	28514442
DGAT1_HUMAN	DGAT1	physical	28514442
HACD2_HUMAN	PTPLB	physical	28514442
AT2B3_HUMAN	ATP2B3	physical	28514442
ZDH17_HUMAN	ZDHHC17	physical	28514442
ZDH21_HUMAN	ZDHHC21	physical	28514442
UB2Q1_HUMAN	UBE2Q1	physical	28514442
ZFPL1_HUMAN	ZFPL1	physical	28514442
CERS5_HUMAN	CERS5	physical	28514442
TMM56_HUMAN	TMEM56	physical	28514442
AT2B4_HUMAN	ATP2B4	physical	28514442
TMM68_HUMAN	TMEM68	physical	28514442
PTN1_HUMAN	PTPN1	physical	28514442
ARV1_HUMAN	ARV1	physical	28514442
VMA21_HUMAN	VMA21	physical	28514442
ORC5_HUMAN	ORC5	physical	28514442
S35F2_HUMAN	SLC35F2	physical	28514442
HMOX2_HUMAN	HMOX2	physical	28514442
CD032_HUMAN	C4orf32	physical	28514442
ATP7A_HUMAN	ATP7A	physical	28514442
PM34_HUMAN	SLC25A17	physical	28514442
CIA30_HUMAN	NDUFAF1	physical	28514442
NDUB1_HUMAN	NDUFB1	physical	28514442
LTMD1_HUMAN	LETMD1	physical	28514442
NDC1_HUMAN	NDC1	physical	28514442
PLCD_HUMAN	AGPAT4	physical	28514442
CSCL1_HUMAN	TMEM63A	physical	28514442
RAB2A_HUMAN	RAB2A	physical	28514442
ABCB9_HUMAN	ABCB9	physical	28514442
HELLS_HUMAN	HELLS	physical	28514442
ZDHC6_HUMAN	ZDHHC6	physical	28514442
NDUB5_HUMAN	NDUFB5	physical	28514442
T120B_HUMAN	TMEM120B	physical	28514442
TCAF2_HUMAN	FAM115C	physical	28514442
S35F5_HUMAN	SLC35F5	physical	28514442
LPAR1_HUMAN	LPAR1	physical	28514442
FITM2_HUMAN	FITM2	physical	28514442
ZDH13_HUMAN	ZDHHC13	physical	28514442
S19A2_HUMAN	SLC19A2	physical	28514442
ATP9A_HUMAN	ATP9A	physical	28514442
YIPF3_HUMAN	YIPF3	physical	28514442
S39A1_HUMAN	SLC39A1	physical	28514442
AT5F1_HUMAN	ATP5F1	physical	28514442
RTL8C_HUMAN	FAM127A	physical	28514442
MBOA5_HUMAN	LPCAT3	physical	28514442
ATP8_HUMAN	ATP8	physical	28514442
SCPDL_HUMAN	SCCPDH	physical	28514442
SNX14_HUMAN	SNX14	physical	28514442
REEP5_HUMAN	REEP5	physical	28514442
TMPPE_HUMAN	TMPPE	physical	28514442
GNPAT_HUMAN	GNPAT	physical	28514442
CERS2_HUMAN	CERS2	physical	28514442
STAT3_HUMAN	STAT3	physical	28514442
PEX16_HUMAN	PEX16	physical	28514442
CTR2_HUMAN	SLC7A2	physical	28514442
MSMO1_HUMAN	MSMO1	physical	28514442
LRC8A_HUMAN	LRRC8A	physical	28514442
TSN15_HUMAN	TSPAN15	physical	28514442
GLMN_HUMAN	GLMN	physical	28514442
AGRL3_HUMAN	LPHN3	physical	28514442
HSDL1_HUMAN	HSDL1	physical	28514442
ACAD9_HUMAN	ACAD9	physical	28514442
SC5D_HUMAN	SC5D	physical	28514442
CERS6_HUMAN	CERS6	physical	28514442
TM160_HUMAN	TMEM160	physical	28514442
MFSD8_HUMAN	MFSD8	physical	28514442
ECSIT_HUMAN	ECSIT	physical	28514442
EDA_HUMAN	EDA	physical	28514442
UBP22_HUMAN	USP22	physical	28514442
CKAP4_HUMAN	CKAP4	physical	28514442
ST7_HUMAN	ST7	physical	28514442
SG196_HUMAN	POMK	physical	28514442
CC115_HUMAN	CCDC115	physical	28514442
NAT14_HUMAN	NAT14	physical	28514442
RMND1_HUMAN	RMND1	physical	28514442
MACOI_HUMAN	TMEM57	physical	28514442
LMBR1_HUMAN	LMBR1	physical	28514442
PLD6_HUMAN	PLD6	physical	28514442
CND3_HUMAN	NCAPG	physical	28514442
ATPB_HUMAN	ATP5B	physical	28514442
SPPL3_HUMAN	SPPL3	physical	28514442
B4GT7_HUMAN	B4GALT7	physical	28514442
UQCC1_HUMAN	UQCC1	physical	28514442
S22AI_HUMAN	SLC22A18	physical	28514442
NDUAC_HUMAN	NDUFA12	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of C3AR_HUMAN

Related Literatures of Post-Translational Modification

Sulfation
Reference	PubMed
"Sulfation of tyrosine 174 in the human C3a receptor is essential forbinding of C3a anaphylatoxin."; Gao J., Choe H., Bota D., Wright P.L., Gerard C., Gerard N.P.; J. Biol. Chem. 278:37902-37908(2003). Cited for: SULFATION AT TYR-174; TYR-184 AND TYR-318.	12871936 [Abstract]