5HT3C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 5HT3C_HUMAN
• UniProt AC: Q8WXA8
• Protein Name: 5-hydroxytryptamine receptor 3C
• Gene Name: HTR3C
• Organism: Homo sapiens (Human).
• Sequence Length: 447
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.
• Protein Description: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel..
• Protein Sequence: MEGGWPARQSALLCLTVSLLLQGRGDAFTINCSGFDQHGVDPAVFQAVFDRKAFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVLAENLWLPDIFIVESMDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPKMSMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMNDLLPASGTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHSLLLHCTSPGRCCPTAPQKGNKGLGLTLTHLPGPKEPGELAGKKLGPRETEPDGGSGWTKTQLMELWVQFSHAMDTLLFRLYLLFMASSILTVIVLWNT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
234	Phosphorylation	MSMGNNLYDQIMFYV CCCCCCHHHHHHHHH	14.13	50517033
398	Phosphorylation	KKLGPRETEPDGGSG CCCCCCCCCCCCCCC	54.84	50517037
404	Phosphorylation	ETEPDGGSGWTKTQL CCCCCCCCCCCHHHH	36.37	50517029
407	Phosphorylation	PDGGSGWTKTQLMEL CCCCCCCCHHHHHHH	27.95	50558119

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 5HT3C_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 5HT3C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 5HT3C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MBOA7_HUMAN	MBOAT7	physical	26186194
LSR_HUMAN	LSR	physical	26186194
MET25_HUMAN	METTL25	physical	26186194
TM87A_HUMAN	TMEM87A	physical	26186194
PIGO_HUMAN	PIGO	physical	26186194
MGAT1_HUMAN	MGAT1	physical	26186194
ALG9_HUMAN	ALG9	physical	26186194
GPAA1_HUMAN	GPAA1	physical	26186194
ENTP6_HUMAN	ENTPD6	physical	26186194
TMTC3_HUMAN	TMTC3	physical	26186194
K2013_HUMAN	KIAA2013	physical	26186194
NSDHL_HUMAN	NSDHL	physical	26186194
TPST2_HUMAN	TPST2	physical	26186194
MANEL_HUMAN	MANEAL	physical	26186194
S38AA_HUMAN	SLC38A10	physical	26186194
MAN1_HUMAN	LEMD3	physical	26186194
S35B2_HUMAN	SLC35B2	physical	26186194
SPP2B_HUMAN	SPPL2B	physical	26186194
TMED4_HUMAN	TMED4	physical	26186194
IDD_HUMAN	DGCR2	physical	26186194
C1GLC_HUMAN	C1GALT1C1	physical	26186194
TM186_HUMAN	TMEM186	physical	26186194
DIA1_HUMAN	C3orf58	physical	26186194
IPRI_HUMAN	ITPRIP	physical	26186194
PGAP1_HUMAN	PGAP1	physical	26186194
SC11C_HUMAN	SEC11C	physical	26186194
AT11C_HUMAN	ATP11C	physical	26186194
RDH11_HUMAN	RDH11	physical	26186194
GRM1A_HUMAN	GRAMD1A	physical	26186194
FZD2_HUMAN	FZD2	physical	26186194
NHLC3_HUMAN	NHLRC3	physical	26186194
CC50A_HUMAN	TMEM30A	physical	26186194
NETO2_HUMAN	NETO2	physical	26186194
WLS_HUMAN	WLS	physical	26186194
FA69B_HUMAN	FAM69B	physical	26186194
ERMP1_HUMAN	ERMP1	physical	26186194
POMT2_HUMAN	POMT2	physical	26186194
FUT8_HUMAN	FUT8	physical	26186194
PIGM_HUMAN	PIGM	physical	26186194
UD3A2_HUMAN	UGT3A2	physical	26186194
IMPA3_HUMAN	IMPAD1	physical	26186194
TMPPE_HUMAN	TMPPE	physical	26186194
FA69A_HUMAN	FAM69A	physical	26186194
SEM4C_HUMAN	SEMA4C	physical	26186194
ABHD3_HUMAN	ABHD3	physical	26186194
CXA1_HUMAN	GJA1	physical	26186194
TM39A_HUMAN	TMEM39A	physical	26186194
TM223_HUMAN	TMEM223	physical	26186194
TM206_HUMAN	TMEM206	physical	26186194
SUN1_HUMAN	SUN1	physical	26186194
S38A9_HUMAN	SLC38A9	physical	26186194
POMT1_HUMAN	POMT1	physical	26186194
SPG7_HUMAN	SPG7	physical	26186194
DAG1_HUMAN	DAG1	physical	26186194
PRAF3_HUMAN	ARL6IP5	physical	26186194
LMF1_HUMAN	LMF1	physical	26186194
WRB_HUMAN	WRB	physical	26186194
TMX2_HUMAN	TMX2	physical	26186194
TUSC3_HUMAN	TUSC3	physical	26186194
TM104_HUMAN	TMEM104	physical	26186194
T179B_HUMAN	TMEM179B	physical	26186194
B4GT1_HUMAN	B4GALT1	physical	26186194
F189B_HUMAN	FAM189B	physical	26186194
AG10A_HUMAN	ALG10	physical	26186194
TM231_HUMAN	TMEM231	physical	26186194
CHSTC_HUMAN	CHST12	physical	26186194
RHBL4_HUMAN	RHBDD1	physical	26186194
LRC8A_HUMAN	LRRC8A	physical	26186194
ABHGA_HUMAN	ABHD16A	physical	26186194
GP1BB_HUMAN	GP1BB	physical	26186194
EDA_HUMAN	EDA	physical	26186194
S47A1_HUMAN	SLC47A1	physical	26186194
CJ035_HUMAN	C10orf35	physical	26186194
LRFN3_HUMAN	LRFN3	physical	26186194
EMC8_HUMAN	EMC8	physical	26186194
LMF2_HUMAN	LMF2	physical	26186194
LNP_HUMAN	KIAA1715	physical	26186194
GOLI_HUMAN	RNF130	physical	26186194
BRI3B_HUMAN	BRI3BP	physical	26186194
ABHGA_HUMAN	ABHD16A	physical	28514442
UD3A2_HUMAN	UGT3A2	physical	28514442
SC11C_HUMAN	SEC11C	physical	28514442
TPST2_HUMAN	TPST2	physical	28514442
TUSC3_HUMAN	TUSC3	physical	28514442
TM186_HUMAN	TMEM186	physical	28514442
TMTC3_HUMAN	TMTC3	physical	28514442
SPP2B_HUMAN	SPPL2B	physical	28514442
TM104_HUMAN	TMEM104	physical	28514442
MET25_HUMAN	METTL25	physical	28514442
S38A9_HUMAN	SLC38A9	physical	28514442
FA69A_HUMAN	FAM69A	physical	28514442
TM231_HUMAN	TMEM231	physical	28514442
S47A1_HUMAN	SLC47A1	physical	28514442
WLS_HUMAN	WLS	physical	28514442
S38AA_HUMAN	SLC38A10	physical	28514442
LRC8A_HUMAN	LRRC8A	physical	28514442
GP1BB_HUMAN	GP1BB	physical	28514442
ALG9_HUMAN	ALG9	physical	28514442
EDA_HUMAN	EDA	physical	28514442
ERMP1_HUMAN	ERMP1	physical	28514442
DAG1_HUMAN	DAG1	physical	28514442
S35B2_HUMAN	SLC35B2	physical	28514442
CXA1_HUMAN	GJA1	physical	28514442
PIGM_HUMAN	PIGM	physical	28514442
IMPA3_HUMAN	IMPAD1	physical	28514442
PIGO_HUMAN	PIGO	physical	28514442
MAN1_HUMAN	LEMD3	physical	28514442
POMT1_HUMAN	POMT1	physical	28514442
TM39A_HUMAN	TMEM39A	physical	28514442
LRFN3_HUMAN	LRFN3	physical	28514442
TM223_HUMAN	TMEM223	physical	28514442
CJ035_HUMAN	C10orf35	physical	28514442
GRM1A_HUMAN	GRAMD1A	physical	28514442
IPRI_HUMAN	ITPRIP	physical	28514442
TMED4_HUMAN	TMED4	physical	28514442
TMPPE_HUMAN	TMPPE	physical	28514442
CHSTC_HUMAN	CHST12	physical	28514442
NETO2_HUMAN	NETO2	physical	28514442
GL8D1_HUMAN	GLT8D1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.