MET25_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MET25_HUMAN
• UniProt AC: Q8N6Q8
• Protein Name: Methyltransferase-like protein 25
• Gene Name: METTL25
• Organism: Homo sapiens (Human).
• Sequence Length: 603
• Protein Description: Putative methyltransferase..
• Protein Sequence: MAASCPLPVTPDLPTLRAKLQGLLQFLRDALSISNAHTVDFYTESVWEELVDLPPETVLAALRKSASETEALPSETRPLVEAEWEAGMTDFPKIFCETSQKLVSVEAFALAAKYYSVQNLGICTPFEQLLVALRGNQNQRIGENQKAVEFMNMKKSHEVQAMSELISSIADYYGIKQVIDLGSGKGYLSSFLSLKYGLKVYGIDSSNTNTHGAEERNRKLKKHWKLCHAQSRLDVNGLALKMAKERKVQNKVKNKADTEEVFNNSPTNQEKMPTSAILPDFSGSVISNIRNQMETLHSQPHQEENLCFENSFSLINLLPINAVEPTSSQQIPNRETSEANKERRKMTSKSSESNIYSPLTSFITADSELHDIIKDLEDCLMVGLHTCGDLAPNTLRIFTSNSEIKGVCSVGCCYHLLSEEFENQHKERTQEKWGFPMCHYLKEERWCCGRNARMSACLALERVAAGQGLPTESLFYRAVLQDIIKDCYGITKCDRHVGKIYSKCSSFLDYVRRSLKKLGLDESKLPEKIIMNYYEKYKPRMNELEAFNMLKVVLAPCIETLILLDRLCYLKEQEDIAWSALVKLFDPVKSPRCYAVIALKKQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
74	Phosphorylation	SETEALPSETRPLVE CCCCCCCCCCCCCHH		23532336
76	Phosphorylation	TEALPSETRPLVEAE CCCCCCCCCCCHHHH		23532336
104	Phosphorylation	ETSQKLVSVEAFALA CCCCHHHHHHHHHHH		29396449
172	Phosphorylation	LISSIADYYGIKQVI HHHHHHHHHCCCEEE		-
173	Phosphorylation	ISSIADYYGIKQVID HHHHHHHHCCCEEEE		-
187	Phosphorylation	DLGSGKGYLSSFLSL ECCCCCCHHHHHHHH		29978859
189	Phosphorylation	GSGKGYLSSFLSLKY CCCCCHHHHHHHHCC		29978859
190	Phosphorylation	SGKGYLSSFLSLKYG CCCCHHHHHHHHCCC		21815630
193	Phosphorylation	GYLSSFLSLKYGLKV CHHHHHHHHCCCEEE		29978859
196	Phosphorylation	SSFLSLKYGLKVYGI HHHHHHCCCEEEEEE		-
201	Phosphorylation	LKYGLKVYGIDSSNT HCCCEEEEEECCCCC		-
210	Phosphorylation	IDSSNTNTHGAEERN ECCCCCCCCCHHHHH		23403867
255	Ubiquitination	VQNKVKNKADTEEVF HHHHCCCCCCHHHHH		29967540
265	Phosphorylation	TEEVFNNSPTNQEKM HHHHHHCCCCCCCCC		25159151
267	Phosphorylation	EVFNNSPTNQEKMPT HHHHCCCCCCCCCCC		22199227
287	Phosphorylation	DFSGSVISNIRNQME CCCCHHHHHHHHHHH		24719451
347	Phosphorylation	NKERRKMTSKSSESN HHHHHHHCCCCCCCC		27251275
348	Phosphorylation	KERRKMTSKSSESNI HHHHHHCCCCCCCCC		27251275
350	Phosphorylation	RRKMTSKSSESNIYS HHHHCCCCCCCCCCC		26657352
351	Phosphorylation	RKMTSKSSESNIYSP HHHCCCCCCCCCCCC		27080861
353	Phosphorylation	MTSKSSESNIYSPLT HCCCCCCCCCCCCHH		27080861
356	Phosphorylation	KSSESNIYSPLTSFI CCCCCCCCCCHHHHH		27642862
357	Phosphorylation	SSESNIYSPLTSFIT CCCCCCCCCHHHHHH		25627689
367	Phosphorylation	TSFITADSELHDIIK HHHHHCCHHHHHHHH		-
505	Phosphorylation	GKIYSKCSSFLDYVR HHHHHHHHHHHHHHH		24260401
506	Phosphorylation	KIYSKCSSFLDYVRR HHHHHHHHHHHHHHH		24260401
510	Phosphorylation	KCSSFLDYVRRSLKK HHHHHHHHHHHHHHH		22817900
534	Phosphorylation	EKIIMNYYEKYKPRM HHHHHHHHHHHCCCC		25690035
583	Ubiquitination	IAWSALVKLFDPVKS HHHHHHHHHHCCCCC		29967540
583	Acetylation	IAWSALVKLFDPVKS HHHHHHHHHHCCCCC		7432025
589	Acetylation	VKLFDPVKSPRCYAV HHHHCCCCCCCEEEE		7672411

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MET25_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MET25_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MET25_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
NRDC_HUMAN	NRD1	physical	28514442
PCBP3_HUMAN	PCBP3	physical	28514442
RPGR1_HUMAN	RPGRIP1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.