| UniProt ID | DSC2_SCHPO | |
|---|---|---|
| UniProt AC | Q9UTK7 | |
| Protein Name | DSC E3 ubiquitin ligase complex subunit 2 | |
| Gene Name | dsc2 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 372 | |
| Subcellular Localization |
Golgi apparatus membrane Multi-pass membrane protein . |
|
| Protein Description | Component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation.. | |
| Protein Sequence | MSSANIVPSNMGITKFLLLTISTSSVVAGVFALKPFFHINFGLHLLSHYQYWRILLWQFIYWNSTEVFQALFIIYQARDVERLLGSHRFASFCVYMFILGMFVTPIFSFLYSLLFKNLDYIQPGPTFLIFAILYQYYYIVPSTVFVRLFNIKFTDKFQMVIPMIGLAFSHFPSTFINAFLGWTMGMFYHLSLLPGTSWRLPIRFVKPALSPTHVFIRPPYSDMQNASTFNPETLFALPTGLDAERTENENQVENPVSNADANDSPTRQNARATAIASSSNTAASFRNRQQISHPPLGRTSSSSVLPTGPASQLYDMLSGRSERPELGNIREEDINTVQTIMQTSRAQAIQALSQTNDVQRAVELLLEQTADY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 246 | Phosphorylation | TGLDAERTENENQVE CCCCHHHCCCCCCCC | 34.37 | 29996109 | |
| 257 | Phosphorylation | NQVENPVSNADANDS CCCCCCCCCCCCCCC | 27.79 | 29996109 | |
| 264 | Phosphorylation | SNADANDSPTRQNAR CCCCCCCCCCHHHHH | 28.16 | 28889911 | |
| 266 | Phosphorylation | ADANDSPTRQNARAT CCCCCCCCHHHHHHH | 49.16 | 28889911 | |
| 284 | Phosphorylation | SSSNTAASFRNRQQI CCCCCHHHHCCCCCC | 23.44 | 25720772 | |
| 299 | Phosphorylation | SHPPLGRTSSSSVLP CCCCCCCCCCCCCCC | 31.03 | 29996109 | |
| 300 | Phosphorylation | HPPLGRTSSSSVLPT CCCCCCCCCCCCCCC | 27.19 | 25720772 | |
| 301 | Phosphorylation | PPLGRTSSSSVLPTG CCCCCCCCCCCCCCC | 26.48 | 25720772 | |
| 302 | Phosphorylation | PLGRTSSSSVLPTGP CCCCCCCCCCCCCCC | 25.00 | 25720772 | |
| 303 | Phosphorylation | LGRTSSSSVLPTGPA CCCCCCCCCCCCCCH | 29.62 | 29996109 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DSC2_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DSC2_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DSC2_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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