MMS22_SCHPO - dbPTM
MMS22_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MMS22_SCHPO
UniProt AC O14207
Protein Name Protein mms22
Gene Name mus7
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1888
Subcellular Localization Nucleus .
Protein Description Involved in protection against replication-dependent DNA damage. May act by restoring active replication forks, repairing unusual DNA structures, and/or preventing aberrant DNA rearrangement at arrested replication forks..
Protein Sequence MNSFLLLDHVSDSQDSGSEWSNTHGSLISQRGNEYDGITPATKEKNQNKLEILNNETTIGSTKSSVSSLPELNRNVSFEKSDQNLAETKREEENKRTEVFKKDAEHEAVVVKRDFRPRRPEQTRPYTYDFLRHQIEFKRIGLVPITVPHGFSSDRSITSKSSHKPVNVIVRNRASSRKPPLTSTHRFRRYGAVISDSDDDESNTEQDHSKESNLNTADNDLALSSTIEGKKTSTSKEALESESLLSDSDQSMTNISSNSTVSDLNLKTLKKRLRGVLPPSFLTLQEKKKLENRGVKKKTSLHKSVIEGEKIKGVARRKLHPRSTAKLSSELGNEISDSDNSISTPTPTDDSRFDTSEFLDSISRDNGWLKEDVVDQLWLPKRSLSALKKSSSLTSENPFQLNVAANAVSTIPVYRTTKTKMKKNRFKYVEVEKLPDLILESYGKKAPKFLRVFARSSSHIPKMIRRKRQMDSKKYFSFDKESDRQVIDQVLSDWYSGKHELVQQSHSYKKPSDSKSVGGNIFSVNSKKHSVNINAKTAANNGLSHLQNFSEELLKKRKLFSSLFSNNVSYKKSKKLKRTHTVHDKCQKVAKLDHYIRDNIELNSKEREHDCYEGTLAVPQVNTEIRKSSRKQKAQRFIRDDFDTVFFQSSSNPNYFTDVNPFWNIGIWSTTFNVITFRPGLSLPNNSFIKTQGLNSILQLDIVTHPFKSVYAFSCLFNIQDDVFKTFEKLKDTFETVLENLPYFTNSETVDLYNLLSFCSAFILHSQVSMGLVNLASSFLETYALVNDRVSSISGLNRSQLVEKIAVLFQTFQVVFYCEFELGNQQNINKVSWLASDLISKLLSAGQSGLLECYRNLRIQASDTTVIDTLFLESWSILNHILFHVYKKKYALWEQVNSFFDLQKKELSILEMEKIWYVIMTLNPVFQIGLNGTTHSPGNNSFWPLIIRVSESAFKMHKDGHNVKVVERYLRTVFLRIHFLISEWRWEDVAQILFLIFDFFSHRKFNDLSSEISEDTPTDFPDFVKSLDRPPNLHVTALDTCFVIYLKVILISISRLRQVDENTNSIKRIVSRLQPLHSRQYTRESPFSIKDFMSLEHTHTLLICLYWAAPENCRPSLNRIRDIVIVDNSHLKARLISLKAWLHLMKYVIKEGTDYELAQGMEWFNSILKVTFDEYLALFSNGTSVGEMQLAEYSKHQLENALIVAFHSLQDLIPNSSVYISRINVLVTEQSCRRILKDSHFFPPRVTLECILFLKKFLQYQSNTEPPKVTVVGSTSHDSQDAYFDSDVLDDNTLILEQEKFERKYEVAQILRTFVSPFLYQTISYLVGNDEDKENYIRILLLPLMECMAICASFAVEAKINDWSYYIDFGSESWERIRNTPLKRSLSTTFYSFLISYNDSFIKKHEEKVLTVWFESLGALDEDHAAQFTILLLQKNLKNPILLNLPISVKIEEISINYFKSVHLNLLTAVFCNMAKLYADAKTNGFASSQYLQSLFIHYLSSLLSSMQHSYETNGHSSDTHSLFVINSQRVVGDILQYCSQFANDRNLPALRYFMDSTKFPQPPERLEYTALRLRSYARKTLTNSASQNALFSFLKANFDVALLEQKQTETSNLLRLAMGFHNQNSSSKWDVEISSLRKFCVKELLLSYLGEGSLAAMFYSLLLLEGLSRTYNSFRRIYLQPYIQQLLCEEISVFVADLEKYALLYENKRPLLSGRIYYLISSFVAISMTNKTSGLPSSLICNLQNFLARIARDFLLELCWNIEGSEFPPPYNTVDCRSKFVKTIQQHCSADWYDNVTNIVHKSRKKKLVLPSQVEQEEEYWSGLMEVTIQIWKHDKGFLEPELDRFLNVICSYAPDMSGLPTKIKCFLDKIGYSWMTEENDFDIVLF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
77PhosphorylationPELNRNVSFEKSDQN
HHHCCCCCCHHHHHC		31.1025720772
383PhosphorylationQLWLPKRSLSALKKS
HHHCCHHHHHHHHHC		32.5721712547
385PhosphorylationWLPKRSLSALKKSSS
HCCHHHHHHHHHCCC		32.5724763107
1052PhosphorylationYLKVILISISRLRQV
HHHHHHHHHHHHHHC		15.8621712547
1054PhosphorylationKVILISISRLRQVDE
HHHHHHHHHHHHCCC		20.6221712547
1065PhosphorylationQVDENTNSIKRIVSR
HCCCCCHHHHHHHHH		27.7021712547
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MMS22_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MMS22_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MMS22_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CSN5_SCHPOcsn5genetic
18931302
PLI1_SCHPOpli1genetic
18931302
RES2_SCHPOres2genetic
18931302
CSN7_SCHPOcsn71genetic
18931302
DDB1_SCHPOddb1genetic
18931302
DAD2_SCHPOdad2genetic
18931302
PUB2_SCHPOpub2genetic
18931302
CCE1_SCHPOcce1genetic
18931302
FEN1_SCHPOrad2genetic
18931302
YDEF_SCHPOSPAC12B10.15cgenetic
18931302
SRS2_SCHPOsrs2genetic
18931302
RAD22_SCHPOrad52genetic
17660542
RAD54_SCHPOrad54genetic
17660542
RAD57_SCHPOrad57genetic
17660542
HUS2_SCHPOrqh1genetic
17660542
DPOD_SCHPOcdc6genetic
17660542
RAD13_SCHPOrad13genetic
17307401
TOP1_SCHPOtop1genetic
17307401
RAD22_SCHPOrad52genetic
17307401
MUS81_SCHPOmus81genetic
17307401
HUS2_SCHPOrqh1genetic
17307401
SWI3_SCHPOswi3genetic
17660542
SWI1_SCHPOswi1genetic
17660542
CHK1_SCHPOchk1genetic
17660542
RAD24_SCHPOrad24physical
26771498
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MMS22_SCHPO

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Related Literatures of Post-Translational Modification

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