PUB2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PUB2_SCHPO
• UniProt AC: Q9UTG2
• Protein Name: E3 ubiquitin-protein ligase pub2
• Gene Name: pub2
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 671
• Subcellular Localization: Membrane ; Peripheral membrane protein . Cytoplasm . Predominantly found at the cell surface of the polar regions.
• Protein Description: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Has a role in the G2/M transition..
• Protein Sequence: MENIRFEVQLTILHVEGLWKNGLLRSLKPYLLISVDDDQFIKTNVASGTLRLSWGFTQKLTVSPQSIILLQLFDEKQKNETSDGFVGLGAAVVNSFLPFNNPKDDYKTRITLRSPSGSYRGSVVCLFKRSKFLPEELPADKSQICTDIIDDASGCAWETRIDEFGHVYYLKSPQLSVISAISHEKLENLTPKQLKEVFSQFLFNNQSKSSLKINLEYKVIKHLLEHYPLALSVRQQVAVEKGPLPAGWEMRLSEDYHVYFVDHSTKTTTWSDPRDNVVASDSVSENTDSIQQINDEYQRKIAYMYDRPEMAVNDAQLQLKVSRATTFEDAYDIISKLSVSDMKKKLLIRFRNEDGLDYGGVSREFFYILSHAIFNPGYSLFEYATDDNYGLQISPLSSVNPDFRSYFRFVGRVMGLAIYHRRYLDVQFVLPFYKRILQKPLCLEDVKDVDEVYYESLKWIKNNDVDESLCLNFSVEENRFGESVTVDLIPNGRNIAVNNQNKMNYLKALTEHKLVTSTEEQFNALKGGLNELIPDSVLQIFNENELDTLLNGKRDIDVQDWKRFTDYRSYTETDDIVIWFWELLSEWSPEKKAKLLQFATGTSRLPLSGFKDMHGSDGPRKFTIEKVGHISQLPKAHTCFNRLDIPPYNSKEELEQKLTIAIQETAGFGTE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
280	Phosphorylation	PRDNVVASDSVSENT CCCCCCCCCCCCCCC	20.86	25720772
284	Phosphorylation	VVASDSVSENTDSIQ CCCCCCCCCCCHHHH	29.13	25720772
287	Phosphorylation	SDSVSENTDSIQQIN CCCCCCCCHHHHHHC	27.37	25720772
289	Phosphorylation	SVSENTDSIQQINDE CCCCCCHHHHHHCHH	21.91	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PUB2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PUB2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PUB2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FLP1_SCHPO	clp1	physical	18418059
UBC13_SCHPO	ubc13	genetic	26365378

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.