dbPTM

CUF1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CUF1_SCHPO
UniProt AC	Q09728
Protein Name	Metal-binding regulatory protein cuf1
Gene Name	cuf1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	411
Subcellular Localization	Cytoplasm . Nucleus . Cytoplasmic in presence of excess copper ions. The Cys-His motif (328-342) interacts with the N-terminal nuclear localization signal region leading to sequestration in the cytoplasm. Nuclear under copper starvation conditions.
Protein Description	Copper-sensing transcription factor that regulates iron uptake genes. Under copper starvation conditions activates the transcription of the copper transport genes, ctr4, ctr5 and ctr6..
Protein Sequence	MVVINNVKMACMKCIRGHRSSTCKHNDRELFPIRPKGRPISQCEKCRIARITRHLHVKCTCNSRKKGSKCSTSSTTDLDSSSASNSSCSIPSSISEKLLPRDNVKTHCPKRSASCCGKKPDVMPLKINLESQTDFMGMPLQSQRPHSESYRMLPEPEKFKSEYGYPSQFLPIEKLTSNVAYPPNYNNYLKSPYQQPTNFPPEIQYNYSHSPQHSIQEAEEAAVYGPPVYRSGYQILYNNNTDSIAAAAATHDLYPQPDVPLTFAMLADGNYVPLPSSTNTYGPSNSYGYEININESTNHVDSSYLPHPIQLSNYFTLPSSCAQADAACQCGDNCECLGCLTHPNNATTLAALNHISALEKETISHTDLHHTFKHEVNSSNNYELTNDELAASSPLYTSSSVPPSHITTGST

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of CUF1_SCHPO !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CUF1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CUF1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CUF1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUF1_SCHPO	cuf1	physical	23695164
MEI4_SCHPO	mei4	genetic	24569997
CUF1_SCHPO	cuf1	physical	26771498

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CUF1_SCHPO

Related Literatures of Post-Translational Modification