AP2B_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AP2B_SCHPO
• UniProt AC: O43005
• Protein Name: AP-2 complex subunit beta
• Gene Name: apl1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 677
• Subcellular Localization: Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane..
• Protein Description: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Beta adaptin is a subunit of the plasma membrane adaptor (By similarity)..
• Protein Sequence: MSSSSSHFSSTAADLLAVFSSDNKDKSANKRISALKKAIAGISYGYDMSSLFPSVISSMESNNLELKKLCYLYLKIYASVKPTEAKRAVKLILNDIYSSNPMIRSLALRTLTSVNIKNFWVAAMDPIVRLLDDTDPYVRKTAAIGIAKLYSYDKKMVESSGLIDHLKEMLSDESSVVVANSLAALMNIVNSSTGFKLTFSREISNKLVKSLTDCSEWLQVAILDALIFYVPQKPGEAESFAERISPWLQHGNAAVCMGAVKVILYLTNYMKDDNRVKEYFMKTQPPLVTLLARKSSATQYVILRNIQIILEQCPEMFANDIHFFYCNFDDPIYVKLEKLDILTKIADIHNLDQILPEFVEYASEIDVELVRKSVKCIGYLAIKIEERKNDCIDSLIELMNTKVTYVIQEAVIVIRDILRKYPGSYKSLVPILYENLDSLDEPDAKSAVIWILGQYAEEIEDSITLLNDYLKGFFDEPLEIQLTLLTAVIKVFLKKPTAAADMVTNVLQWCTDEVNDPDLRDRGIIYSRMLSANPELAKKVILANMPPVNVGTGMYDPDTTEQLMLNISTLSSIYHKPPNRFVKGAQVAYCEPSPVLRLRTRDSNPSNTDSRESNHKKYNHFHQKSQTRRVMEQYDRNSWNPSPFSDESNSNTFSGKFDSADQENLGMPMTPETHLMD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSSSSHFS ------CCCCCHHHH	38.64	21712547
3	Phosphorylation	-----MSSSSSHFSS -----CCCCCHHHHC	32.70	21712547
638	Phosphorylation	MEQYDRNSWNPSPFS HHHHHCCCCCCCCCC	29.17	29996109
642	Phosphorylation	DRNSWNPSPFSDESN HCCCCCCCCCCCCCC	35.05	29996109
645	Phosphorylation	SWNPSPFSDESNSNT CCCCCCCCCCCCCCC	43.80	29996109
648	Phosphorylation	PSPFSDESNSNTFSG CCCCCCCCCCCCCCC	51.02	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AP2B_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AP2B_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AP2B_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of AP2B_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.