TF2L1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TF2L1_MOUSE
• UniProt AC: Q3UNW5
• Protein Name: Transcription factor CP2-like protein 1
• Gene Name: Tfcp2l1
• Organism: Mus musculus (Mouse).
• Sequence Length: 479
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs). [PubMed: 23942233]
• Protein Sequence: MLFWHTQPEHYNQHNSGSYLRDVLALPIFKQEEPQLSPENGARLPPLQYVLCAATSPAVKLHEETLTYLNQGQSYEIRLLENRKLGDFQDLNTKYVKSIIRVVFHDRRLQYTEYQQLEGWRWSRPGDRILDIDIPLSVGILDPRASPTQLNAVEFLWDPSKRASAFIQVHCISTEFTPRKHGGEKGVPFRVQIDTFKQNESGDYSEHLHSASCQIKVFKPKGADRKQKTDREKMEKRTAQEKEKYQPSYETTILTECSPWPDVPYQANNTPSPSYNGSPNSFGLREGNSSPNHPVEPLPLGSDHLLPSASIQDAQQWLHRNRFSQFCWLFASFSGADLLKMSRDDLVQVCGPADGIRLFNAIKGRNVRPKMTIYVCQELEQNQLPLPQKQDDSGDNSLCVYHAIFLEELTTLELTEKIASLYSIPPQHIHRVYRQGPAGIHVVVSNEMVQNFQDESCFILSTLKAESNDGYHIILKCGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	KQEEPQLSPENGARL CCCCCCCCCCCCCCC	25.56	26239621
84	Ubiquitination	IRLLENRKLGDFQDL EEEECCCCCCCHHHC	69.29	22790023
84	Ubiquitination	IRLLENRKLGDFQDL EEEECCCCCCCHHHC	69.29	22790023
111	Phosphorylation	FHDRRLQYTEYQQLE HCCCCCCCEEEHHHC	13.21	30635358
112	Phosphorylation	HDRRLQYTEYQQLEG CCCCCCCEEEHHHCC	18.43	30635358
114	Phosphorylation	RRLQYTEYQQLEGWR CCCCCEEEHHHCCCC	8.18	30635358
177	Phosphorylation	HCISTEFTPRKHGGE EEEECCCCCCCCCCC	18.89	-
289	Phosphorylation	FGLREGNSSPNHPVE CCCCCCCCCCCCCCC	59.01	26239621
290	Phosphorylation	GLREGNSSPNHPVEP CCCCCCCCCCCCCCC	33.45	26239621
308	Phosphorylation	GSDHLLPSASIQDAQ CCCCCCCCCCHHHHH	34.32	26239621
310	Phosphorylation	DHLLPSASIQDAQQW CCCCCCCCHHHHHHH	25.72	26239621
401	Phosphorylation	GDNSLCVYHAIFLEE CCCCCHHHHHHHHHH	5.64	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
177	T	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TF2L1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TF2L1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHD4_MOUSE	Chd4	physical	20362541
P66A_MOUSE	Gatad2a	physical	20362541
MTA1_MOUSE	Mta1	physical	20362541
MTA2_MOUSE	Mta2	physical	20362541
P66B_MOUSE	Gatad2b	physical	20362541
HDAC1_MOUSE	Hdac1	physical	20362541
RBBP7_MOUSE	Rbbp7	physical	20362541
HDAC2_MOUSE	Hdac2	physical	20362541
MTA3_MOUSE	Mta3	physical	20362541
MBD3_MOUSE	Mbd3	physical	20362541
MBD2_MOUSE	Mbd2	physical	20362541
RUVB2_MOUSE	Ruvbl2	physical	20362541
EP400_MOUSE	Ep400	physical	20362541
RUVB1_MOUSE	Ruvbl1	physical	20362541
ACL6A_MOUSE	Actl6a	physical	20362541
YETS4_MOUSE	Yeats4	physical	20362541
VPS72_MOUSE	Vps72	physical	20362541
DMAP1_MOUSE	Dmap1	physical	20362541
BRD8_MOUSE	Brd8	physical	20362541
ING3_MOUSE	Ing3	physical	20362541
MRGBP_MOUSE	Mrgbp	physical	20362541
SMRC1_MOUSE	Smarcc1	physical	20362541
SMCA4_MOUSE	Smarca4	physical	20362541
ARI1A_MOUSE	Arid1a	physical	20362541
SMRC2_MOUSE	Smarcc2	physical	20362541
SMCE1_MOUSE	Smarce1	physical	20362541
SMRD1_MOUSE	Smarcd1	physical	20362541
SNF5_MOUSE	Smarcb1	physical	20362541
SMRD2_MOUSE	Smarcd2	physical	20362541
RING2_MOUSE	Rnf2	physical	20362541
PHC1_MOUSE	Phc1	physical	20362541
PCGF6_MOUSE	Pcgf6	physical	20362541
RYBP_MOUSE	Rybp	physical	20362541
SALL4_MOUSE	Sall4	physical	20362541
UBIP1_MOUSE	Ubp1	physical	20362541
TFCP2_MOUSE	Tfcp2	physical	20362541
KDM1A_MOUSE	Kdm1a	physical	20362541
ERR2_MOUSE	Esrrb	physical	20362541
SMCA5_MOUSE	Smarca5	physical	20362541
WDR5_MOUSE	Wdr5	physical	20362541
PEG10_MOUSE	Peg10	physical	20362541
YETS2_MOUSE	Yeats2	physical	20362541
HCFC1_MOUSE	Hcfc1	physical	20362541
ZMYM4_MOUSE	Zmym4	physical	20362541
HELLS_MOUSE	Hells	physical	20362541
MGAP_MOUSE	Mga	physical	20362541
PO5F1_MOUSE	Pou5f1	physical	20362541
REQU_MOUSE	Dpf2	physical	20362541
POGZ_MOUSE	Pogz	physical	20362541
ZN143_MOUSE	Zfp143	physical	20362541
SIN3A_MOUSE	Sin3a	physical	20362541
ROAA_MOUSE	Hnrnpab	physical	20362541
WIZ_MOUSE	Wiz	physical	20362541
SATB2_MOUSE	Satb2	physical	20362541
KIF5A_MOUSE	Kif5a	physical	20362541
TRI33_MOUSE	Trim33	physical	20362541
MYBB_MOUSE	Mybl2	physical	20362541
GRHL2_MOUSE	Grhl2	physical	20362541
LMBL2_MOUSE	L3mbtl2	physical	20362541
ZZZ3_MOUSE	Zzz3	physical	20362541
EHMT1_MOUSE	Ehmt1	physical	20362541
CHAP1_MOUSE	Champ1	physical	20362541
RIF1_MOUSE	Rif1	physical	20362541
ZCHC8_MOUSE	Zcchc8	physical	20362541
SP16H_MOUSE	Supt16	physical	20362541
OGT1_MOUSE	Ogt	physical	20362541
XRCC6_MOUSE	Xrcc6	physical	20362541
XRCC5_MOUSE	Xrcc5	physical	20362541
MSH2_MOUSE	Msh2	physical	20362541
LITD1_MOUSE	L1td1	physical	20362541
MSH6_MOUSE	Msh6	physical	20362541
RBM14_MOUSE	Rbm14	physical	20362541
XRCC1_MOUSE	Xrcc1	physical	20362541
DPOLB_MOUSE	Polb	physical	20362541
EMSY_MOUSE	2210018M11Rik	physical	20362541
RFA1_MOUSE	Rpa1	physical	20362541
PRKDC_MOUSE	Prkdc	physical	20362541
KANL3_MOUSE	Kansl3	physical	20362541
AKAP8_MOUSE	Akap8	physical	20362541
ASF1A_MOUSE	Asf1a	physical	20362541
CAMP3_MOUSE	Camsap3	physical	20362541
UBQL4_MOUSE	Ubqln4	physical	20362541

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.