KANL3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KANL3_MOUSE
• UniProt AC: A2RSY1
• Protein Name: KAT8 regulatory NSL complex subunit 3
• Gene Name: Kansl3
• Organism: Mus musculus (Mouse).
• Sequence Length: 903
• Subcellular Localization: Nucleus.
• Protein Description: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription..
• Protein Sequence: MAHRGGERDFQTSARRMGTSLLFQLSVHERELDLVFLDHSYAKPWSAHPDASSARPTRMLFVTPRRQQENTIESDVPIDVETVTATPVPLYDNQKARSVMNECERHVIFARTDADAPPPPEDWEEHVNRTGWTVAQNKLFNKILKALQSDRLARLANEGACNEPVLRRVAVDKCARRVRQALASVSWDTKLTQWLHTTLVETLSLPMLAAYLDALQTLKGKIPTLIDRMLVSSNTKTGAAGAEALSLLLKRPWDPAVGVLSHNKPSKLPGSPLILIVSSGPSSSVFPASRRHRFWQSQLSCLGKVIPVATHLLNNGSGVGVLQCLEHMIGAVRSKVLEIHSHFPHKPIILIGWNTGALVACHVSVMEYVTAVVCLGFPLLTVDGPRGDVDDPLLDMKTPVLFVIGQNSLQCHPEAMEDFREKIRAENSLVVVGGADDNLRISKAKKKSEGLTQSMVDRCIQDEIVDFLTGVLTRAEGHVGSEPRDQDAEKKKKPRDLTRRDLAFEIPERGSRPASPAARLPTSPSGSEDLSSVSSSPTSSPKTKVTTVTSTQKSSQIGTSQLLKRHVQRTEAVLTHRQAQAQFAAFLKQNMLVRKAFPPGTSSCLFVPISSESVEDIEKEELRVQLKRHHSSSPLPGAKPSKRPKIKVSLISQGDTVGGPCTLSQGGTPEAAGGKPITMTLGASAGAKELTGLLTTAKSSSSEGGGTASTTPSVASSSATPNAIHTLQSRLVATSPGSSLPGTASASSLLQGLSFSLQDISSKTSGLPGSPSPGPAPQATSVKLPTPMQSLGAITTGTSTIVRTIPVATTLSSLGATPGGKPTAIHQLLTNGSLAKLASSLPGLAQISNQASGLKVPTTITLTLRGQPSRITTLSPMGSGATPSEEPNSQMLPSSSQRLPPAP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
63	Phosphorylation	PTRMLFVTPRRQQEN CEEEEEECCCHHCCC	12.07	-
184	Phosphorylation	RVRQALASVSWDTKL HHHHHHHHCCCCHHH	19.96	26643407
186	Phosphorylation	RQALASVSWDTKLTQ HHHHHHCCCCHHHHH	19.42	26643407
261	Phosphorylation	DPAVGVLSHNKPSKL CCCCCHHCCCCCCCC	23.70	25338131
493	Acetylation	QDAEKKKKPRDLTRR CCHHHHCCCCCCCHH	54.91	19856595
511	Phosphorylation	FEIPERGSRPASPAA HCCCCCCCCCCCCCC	41.11	21082442
515	Phosphorylation	ERGSRPASPAARLPT CCCCCCCCCCCCCCC	20.11	21082442
522	Phosphorylation	SPAARLPTSPSGSED CCCCCCCCCCCCCCC	58.84	21082442
523	Phosphorylation	PAARLPTSPSGSEDL CCCCCCCCCCCCCCH	18.35	21082442
525	Phosphorylation	ARLPTSPSGSEDLSS CCCCCCCCCCCCHHH	55.51	25521595
527	Phosphorylation	LPTSPSGSEDLSSVS CCCCCCCCCCHHHCC	32.07	28833060
531	Phosphorylation	PSGSEDLSSVSSSPT CCCCCCHHHCCCCCC	40.80	28833060
532	Phosphorylation	SGSEDLSSVSSSPTS CCCCCHHHCCCCCCC	33.06	28833060
534	Phosphorylation	SEDLSSVSSSPTSSP CCCHHHCCCCCCCCC	27.35	28833060
535	Phosphorylation	EDLSSVSSSPTSSPK CCHHHCCCCCCCCCC	37.88	28833060
536	Phosphorylation	DLSSVSSSPTSSPKT CHHHCCCCCCCCCCC	25.37	21082442
538	Phosphorylation	SSVSSSPTSSPKTKV HHCCCCCCCCCCCEE	43.73	28833060
539	Phosphorylation	SVSSSPTSSPKTKVT HCCCCCCCCCCCEEE	48.29	28833060
540	Phosphorylation	VSSSPTSSPKTKVTT CCCCCCCCCCCEEEE	32.66	21082442
543	Phosphorylation	SPTSSPKTKVTTVTS CCCCCCCCEEEEEEC	33.85	29895711
546	Phosphorylation	SSPKTKVTTVTSTQK CCCCCEEEEEECCCC	19.66	29895711
547	Phosphorylation	SPKTKVTTVTSTQKS CCCCEEEEEECCCCC	25.44	29895711
549	Phosphorylation	KTKVTTVTSTQKSSQ CCEEEEEECCCCCCC	24.78	29895711
550	Phosphorylation	TKVTTVTSTQKSSQI CEEEEEECCCCCCCC	25.22	21183079
551	Phosphorylation	KVTTVTSTQKSSQIG EEEEEECCCCCCCCC	30.56	21183079
555	Phosphorylation	VTSTQKSSQIGTSQL EECCCCCCCCCHHHH	32.62	21183079
559	Phosphorylation	QKSSQIGTSQLLKRH CCCCCCCHHHHHHHH	18.22	29895711
560	Phosphorylation	KSSQIGTSQLLKRHV CCCCCCHHHHHHHHH	17.39	29895711
631	Phosphorylation	VQLKRHHSSSPLPGA HHHHHHCCCCCCCCC	26.79	29472430
632	Phosphorylation	QLKRHHSSSPLPGAK HHHHHCCCCCCCCCC	31.45	28418008
633	Phosphorylation	LKRHHSSSPLPGAKP HHHHCCCCCCCCCCC	33.21	25266776
641	Phosphorylation	PLPGAKPSKRPKIKV CCCCCCCCCCCCEEE	40.36	25266776
734	Phosphorylation	LQSRLVATSPGSSLP HHHCCEECCCCCCCC	28.16	25338131
735	Phosphorylation	QSRLVATSPGSSLPG HHCCEECCCCCCCCC	19.95	23649490
739	Phosphorylation	VATSPGSSLPGTASA EECCCCCCCCCCCCH	44.49	23649490
764	Phosphorylation	LQDISSKTSGLPGSP HHHHHHCCCCCCCCC	29.94	29472430
765	Phosphorylation	QDISSKTSGLPGSPS HHHHHCCCCCCCCCC	41.91	26643407
770	Phosphorylation	KTSGLPGSPSPGPAP CCCCCCCCCCCCCCC	21.92	25266776
772	Phosphorylation	SGLPGSPSPGPAPQA CCCCCCCCCCCCCCC	44.16	26643407
809	Phosphorylation	VRTIPVATTLSSLGA EECCCCCCCHHHCCC	28.62	-
858	O-linked_Glycosylation	ASGLKVPTTITLTLR CCCCCCCEEEEEEEC	33.54	51588447
872	Phosphorylation	RGQPSRITTLSPMGS CCCCCEEEEEECCCC	22.15	25777480
873	Phosphorylation	GQPSRITTLSPMGSG CCCCEEEEEECCCCC	23.90	25777480
875	Phosphorylation	PSRITTLSPMGSGAT CCEEEEEECCCCCCC	15.68	25777480
879	Phosphorylation	TTLSPMGSGATPSEE EEEECCCCCCCCCCC	21.00	25777480
882	Phosphorylation	SPMGSGATPSEEPNS ECCCCCCCCCCCCCC	30.76	25777480
884	Phosphorylation	MGSGATPSEEPNSQM CCCCCCCCCCCCCCC	50.68	25777480
889	Phosphorylation	TPSEEPNSQMLPSSS CCCCCCCCCCCCCHH	27.90	25777480
894	Phosphorylation	PNSQMLPSSSQRLPP CCCCCCCCHHCCCCC	38.36	25777480
895	Phosphorylation	NSQMLPSSSQRLPPA CCCCCCCHHCCCCCC	28.66	25777480
896	Phosphorylation	SQMLPSSSQRLPPAP CCCCCCHHCCCCCCC	24.53	25777480

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KANL3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KANL3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KANL3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of KANL3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.