| UniProt ID | PEG10_MOUSE | |
|---|---|---|
| UniProt AC | Q7TN75 | |
| Protein Name | Retrotransposon-derived protein PEG10 | |
| Gene Name | Peg10 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 958 | |
| Subcellular Localization | Nucleus. Cytoplasm. Detected predominantly in the cytoplasm of breast and prostate carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells. Colocalized with ALK1 (By similarity).. | |
| Protein Description | May have a role in cell growth promotion, apoptotic resistance and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1 (By similarity). Involved at the immediate early stage of adipocyte differentiation. May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter.. | |
| Protein Sequence | MAAAGGSSNCPPPPPPPPPNNNNNNNTPKSPGVPDAEDDDERRHDELPEDINNFDEDMNRQFENMNLLDQVELLAQSYSLLDHLDDFDDDDEDDDFDPEPDQDELPEYSDDDDLELQGAAAAPIPNFFSDDDCLEDLPEKFDGNPDMLGPFMYQCQLFMEKSTRDFSVDRIRVCFVTSMLIGRAARWATAKLQRCTYLMHNYTAFMMELKHVFEDPQRREAAKRKIRRLRQGPGPVVDYSNAFQMIAQDLDWTEPALMDQFQEGLNPDIRAELSRQEAPKTLAALITACIHIERRLARDAAAKPDPSPRALVMPPNSQTDPTEPVGGARMRLSKEEKERRRKMNLCLYCGNGGHFADTCPAKASKNSPPGKLPGPAVGGPSATGPERIRSPPSEASTQHLQVMLQIHMPGRPTLFVRAMIDSGASGNFIDQDFVIQNAIPLRIKDWPVMVEAIDGHPIASGPIILETHHLIVDLGDHREILSFDVTQSPFFPIVLGIRWLSTHDPHITWSTRSIVFNSDYCRLRCRMFAQIPSNLLFTVPQPNLHPYLLHHVHPHVHPHMHQHLHQHLHQFLHPDPHQYPHPDPHYHHHQQADMQHQLQQYLYQYLYYHLYPVMHHHLPPDQHEHLHEYLHQYLHQYLHQFLHHHLHPDLHQYLYQYLHNHMNPDPHHHPHPDPPQDPHHPPHQDPHQHPDPHQDPPHQDPHQDAHQDPHMDPHLHQHQHPQPQPHPQQHPNHPQQPPFFYHMAGFRIYHPVRYYYIQNVYTPVDEHVYPGHRVVDPNIEMIPGAHSLPSGHLYSMSESEMNALRNFVDRNVKDGLMTPTVAPNGAQVLQVKRGWKLQVTYNCRAPQSGTIQNQYLRMSLPNMGDPAHLASYGEFVQVPGYPYPAYVYYTSPHMMTAWYPVGRDVHGRIIVVPVVITWSQNTNRQPPVPQYPPPQPPPPPPPPPPPPPPPPASSCSAA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 30 | Phosphorylation | NNNNTPKSPGVPDAE CCCCCCCCCCCCCCC | 28.26 | 21149613 | |
| 161 | Ubiquitination | QCQLFMEKSTRDFSV HHHHHHCCCCCCCCC | 45.39 | - | |
| 191 | Ubiquitination | AARWATAKLQRCTYL HHHHHHHHHHHHHHH | 40.58 | - | |
| 210 | Ubiquitination | TAFMMELKHVFEDPQ HHHHHHHHHHHCCHH | 25.15 | - | |
| 280 | Ubiquitination | LSRQEAPKTLAALIT HHHCCCHHHHHHHHH | 64.32 | - | |
| 303 | Ubiquitination | LARDAAAKPDPSPRA HHHHHHCCCCCCCCC | 45.27 | 27667366 | |
| 307 | Phosphorylation | AAAKPDPSPRALVMP HHCCCCCCCCCEECC | 34.10 | 21149613 | |
| 334 | Ubiquitination | GARMRLSKEEKERRR HHHCCCCHHHHHHHH | 74.59 | - | |
| 342 | Ubiquitination | EEKERRRKMNLCLYC HHHHHHHHCEEEEEC | 30.26 | - | |
| 364 (in isoform 2) | Phosphorylation | - | 31.50 | 22006019 | |
| 367 (in isoform 2) | Phosphorylation | - | 35.89 | 29233185 | |
| 390 | Phosphorylation | TGPERIRSPPSEAST CCCCCCCCCCCHHHH | 38.50 | 26824392 | |
| 753 | Methylation | FRIYHPVRYYYIQNV CEECCCCEEEEEEEE | 20.42 | 24129315 | |
| 754 | Phosphorylation | RIYHPVRYYYIQNVY EECCCCEEEEEEEEE | 10.80 | 25293948 | |
| 755 | Phosphorylation | IYHPVRYYYIQNVYT ECCCCEEEEEEEEEC | 5.41 | 25293948 | |
| 756 | Phosphorylation | YHPVRYYYIQNVYTP CCCCEEEEEEEEECC | 6.26 | 25293948 | |
| 761 | Phosphorylation | YYYIQNVYTPVDEHV EEEEEEEECCCCCCC | 16.93 | 25293948 | |
| 762 | Phosphorylation | YYIQNVYTPVDEHVY EEEEEEECCCCCCCC | 16.74 | 25293948 | |
| 769 | Phosphorylation | TPVDEHVYPGHRVVD CCCCCCCCCCCCCCC | 12.85 | 25293948 | |
| 794 | Phosphorylation | SLPSGHLYSMSESEM CCCCCCEECCCHHHH | 9.17 | 26060331 | |
| 795 | Phosphorylation | LPSGHLYSMSESEMN CCCCCEECCCHHHHH | 23.38 | 26060331 | |
| 813 | Ubiquitination | NFVDRNVKDGLMTPT HHHHHCCCCCCCCCC | 50.02 | - | |
| 818 | Phosphorylation | NVKDGLMTPTVAPNG CCCCCCCCCCCCCCC | 22.35 | 26370283 | |
| 820 | Phosphorylation | KDGLMTPTVAPNGAQ CCCCCCCCCCCCCCE | 21.82 | 26060331 | |
| 832 | Ubiquitination | GAQVLQVKRGWKLQV CCEEEEEECCEEEEE | 32.03 | - | |
| 844 | Methylation | LQVTYNCRAPQSGTI EEEEEECCCCCCCCC | 45.74 | 24129315 | |
| 857 | Methylation | TIQNQYLRMSLPNMG CCCCCEECHHCCCCC | 14.01 | 24129315 | |
| 861 | Ubiquitination | QYLRMSLPNMGDPAH CEECHHCCCCCCHHH | 22.81 | 27667366 | |
| 880 | Ubiquitination | GEFVQVPGYPYPAYV CCEEECCCCCCCEEE | 36.87 | 27667366 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PEG10_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PEG10_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PEG10_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PEG10_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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