ZN143_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN143_MOUSE
• UniProt AC: O70230
• Protein Name: Zinc finger protein 143
• Gene Name: Znf143
• Organism: Mus musculus (Mouse).
• Sequence Length: 638
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8 (By similarity)..
• Protein Sequence: MLLAQINRDSQGMTEFPGGGMEAQHVTLCLTEAVTVADGDNLENMEGVSLQAVTLADGSTAYIQHNSKDGRLIDGQVIQLEDGSAAYVQHVPIPKSTGDSLRLEDGQAVQLEDGTTAFIHHTSKDSYDQSSLQAVQLEDGTTAYIHHAVQVPQSDTILAIQADGTVAGLHTGDATIDPDTISALEQYAAKVSIDGSDGVTSTGMIGENEQEKKMQIVLQGHATRVTPKSQQSGEKAFRCKYDGCGKLYTTAHHLKVHERSHTGDRPYQCEHSGCGKAFATGYGLKSHFRTHTGEKPYRCSEDNCTKSFKTSGDLQKHIRTHTGERPFKCPIEGCGRSFTTSNIRKVHIRTHTGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTHSKPYNCNHCGKTYKQISTLAMHKRTAHNDTEPIEEEQEAFFEPPPGQGDDVLKGSQITYVTGVDGEDIVSTQVATVTQSGLSQQVTLISQDGTQHVNISQADMQAIGNTITMVTQDGTPITVPTHDAVISSAGTHSVAMVTAEGTEGQQVAIVAQDLAAFHTASSEMGHQQHSHHLVTTETRPLTLVATSNGTQIAVQLGEQPSLEEAIRIASRIQQGETPGLDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MLLAQINR -------CCEEECCC	6.63	-
262	Phosphorylation	KVHERSHTGDRPYQC EEECCCCCCCCCEEC	41.86	25266776
337	Phosphorylation	PIEGCGRSFTTSNIR CCCCCCCCEECCCEE	16.54	28285833
338	Phosphorylation	IEGCGRSFTTSNIRK CCCCCCCEECCCEEE	9.23	24719451
339	Phosphorylation	EGCGRSFTTSNIRKV CCCCCCEECCCEEEE	30.48	24719451
341	Phosphorylation	CGRSFTTSNIRKVHI CCCCEECCCEEEEEE	27.48	28285833
350	Phosphorylation	IRKVHIRTHTGERPY EEEEEEEECCCCCCE	24.16	26643407
352	Phosphorylation	KVHIRTHTGERPYYC EEEEEECCCCCCEEE	39.87	26643407
357	Phosphorylation	THTGERPYYCTEPGC ECCCCCCEEECCCCC	19.86	26643407
399	Phosphorylation	PGCDKRFTEYSSLYK CCCCCCHHHHHHHHC	37.74	-
402	Phosphorylation	DKRFTEYSSLYKHHV CCCHHHHHHHHCCCE	13.97	29176673
403	Phosphorylation	KRFTEYSSLYKHHVV CCHHHHHHHHCCCEE	34.51	29176673
405	Phosphorylation	FTEYSSLYKHHVVHT HHHHHHHHCCCEEEC	15.38	28576409

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN143_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN143_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN143_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PO5F1_MOUSE	Pou5f1	physical	18687992

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.