ING3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ING3_MOUSE
• UniProt AC: Q8VEK6
• Protein Name: Inhibitor of growth protein 3
• Gene Name: Ing3
• Organism: Mus musculus (Mouse).
• Sequence Length: 421
• Subcellular Localization: Nucleus.
• Protein Description: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome (By similarity)..
• Protein Sequence: MLYLEDYLEMIEQLPMDLRDRFTEMREMDLQVQNAMDQLEQRVSEFFMNAKKNKPEWREEQMASIKKDYYKALEDADEKVQLANQIYDLVDRHLRKLDQELAKFKMELEADNAGITEILERRSLELDAPSQPVNNHHAHSHTPVEKRKYNPTSHHAAADHIPEKKFKSEALLSTLTSDASKENTLGCRNNNSTASCNNAYNVNSSQPLASYNIGSLSSGAGAGAITMAAAQAVQATAQMKEGRRTSSLKASYEAFKNNDFQLGKEFSIPRETAGYSSSSALMTTLTQNASSSATDSRSGRKSKNNTKSSSQQSSSSSSSSSSSSLSLCSSSSTVVQEVSQQATVVPESDSNSQVDWTYDPNEPRYCICNQVSYGEMVGCDNQDCPIEWFHYGCVGLTEAPKGKWFCPQCTAAMKRRGSRHK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
123	Phosphorylation	TEILERRSLELDAPS HHHHHHCCCCCCCCC	32.20	25338131
164	Acetylation	AADHIPEKKFKSEAL CHHCCCHHHCCHHHH	59.15	23806337
167	Acetylation	HIPEKKFKSEALLST CCCHHHCCHHHHHHH	57.15	23806337
177	Phosphorylation	ALLSTLTSDASKENT HHHHHHCCCHHHCCC	34.00	25521595
180	Phosphorylation	STLTSDASKENTLGC HHHCCCHHHCCCCCC	45.55	25521595
181	Acetylation	TLTSDASKENTLGCR HHCCCHHHCCCCCCC	57.62	23806337
264	Acetylation	NNDFQLGKEFSIPRE CCCCCCCCCEECCHH	65.27	23806337
267	Phosphorylation	FQLGKEFSIPRETAG CCCCCCEECCHHHCC	32.54	26525534
272	Phosphorylation	EFSIPRETAGYSSSS CEECCHHHCCCCCHH	27.02	22871156
275	Phosphorylation	IPRETAGYSSSSALM CCHHHCCCCCHHHHH	11.69	22871156
276	Phosphorylation	PRETAGYSSSSALMT CHHHCCCCCHHHHHH	23.87	22871156
403	Acetylation	LTEAPKGKWFCPQCT CCCCCCCCCCCHHHH	43.13	23806337
410	Phosphorylation	KWFCPQCTAAMKRRG CCCCHHHHHHHHHHC	16.53	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ING3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ING3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ING3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ING3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.