TFCP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TFCP2_MOUSE
• UniProt AC: Q9ERA0
• Protein Name: Alpha-globin transcription factor CP2
• Gene Name: Tfcp2
• Organism: Mus musculus (Mouse).
• Sequence Length: 502
• Subcellular Localization: Nucleus.
• Protein Description: Binds a variety of cellular promoters including fibrinogen, alpha-globin promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter (By similarity)..
• Protein Sequence: MAWALKLPLADEVIESGLVQDFDASLSGIGQELGAGAYSMSDVLALPIFKQEESSLPPDNENEILPFQYVLCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKLGELPELNGKLVKSIFRVVFHDRRLQYTEHQQLEGWRWNRPGDRILDIDIPMSVGVIDPRANPTQLNTVEFLWDPSKRTSVFIQVHCISTEFTMRKHGGEKGVPFRVQIDTFKENGNGEYTEHLHSASCQIKVFKPKGADRKQKIDREKMEKRTPHEKEKYQPSYETTILTECSPWPEITYVNNSPSPGFNSSHSSFSLGEGNGSPNHQPEPPPPVTDNLLPTTTPQEAQQWLHRNRFSTFTRLFTNFSGADLLKLTRDDVIQICGPADGIRLFNALKGRMVRPRLTIYVCQESLQLREQQPQPQPQPQKQEDGDSNGTFFVYHAIYLEELTAVELTEKIAQLFSISPHQISQIYKQGPTGIHVVISDEMVQNFQEEACFILDTMEAETSDSYHVILK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
55	Phosphorylation	IFKQEESSLPPDNEN HHCCCHHCCCCCCCC	48.45	25338131
309	Phosphorylation	SLGEGNGSPNHQPEP CCCCCCCCCCCCCCC	26.91	21082442
350	Phosphorylation	STFTRLFTNFSGADL HHHHHHHHCCCCCHH	39.69	23984901
353	Phosphorylation	TRLFTNFSGADLLKL HHHHHCCCCCHHHHC	34.83	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TFCP2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TFCP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TFCP2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TF2L1_MOUSE	Tfcp2l1	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.