SATB2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SATB2_MOUSE
• UniProt AC: Q8VI24
• Protein Name: DNA-binding protein SATB2
• Gene Name: Satb2
• Organism: Mus musculus (Mouse).
• Sequence Length: 733
• Subcellular Localization: Nucleus matrix .
• Protein Description: Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating Bcl11b expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation..
• Protein Sequence: MERRSESPCLRDSPDRRSGSPDVKGPPPVKVARLEQNGSPMGARGRPNGAVAKAVGGLMIPVFCVVEQLDGSLEYDNREEHAEFVLVRKDVLFSQLVETALLALGYSHSSAAQAQGIIKLGRWNPLPLSYVTDAPDATVADMLQDVYHVVTLKIQLQSCSKLEDLPAEQWNHATVRNALKELLKEMNQSTLAKECPLSQSMISSIVNSTYYANVSATKCQEFGRWYKKYKKIKVERVERENLSDYCVLGQRPMHLPNMNQLASLGKTNEQSPHSQIHHSTPIRNQVPALQPIMSPGLLSPQLSPQLVRQQIAMAHLINQQIAVSRLLAHQHPQAINQQFLNHPPIPRAVKPEPTNSSVEVSPDIYQQVRDELKRASVSQAVFARVAFNRTQGLLSEILRKEEDPRTASQSLLVNLRAMQNFLNLPEVERDRIYQDERERSMNPNVSMVSSASSSPSSSRTPQAKTSTPTTDLPIKVDGANVNITAAIYDEIQQEMKRAKVSQALFAKVAANKSQGWLCELLRWKENPSPENRTLWENLCTIRRFLNLPQHERDVIYEEESRHHHSERMQHVVQLPPEPVQVLHRQQSQPTKESSPPREEAPPPPPPTEDSCAKKPRSRTKISLEALGILQSFIHDVGLYPDQEAIHTLSAQLDLPKHTIIKFFQNQRYHVKHHGKLKEHLGSAVDVAEYKDEELLTESEENDSEEGSEEMYKVEAEEENADKSKAAPAETDQR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MERRSESPCLRD ---CCCCCCCCCCCC	48.96	28066266
7	Phosphorylation	-MERRSESPCLRDSP -CCCCCCCCCCCCCC	23.35	28066266
13	Phosphorylation	ESPCLRDSPDRRSGS CCCCCCCCCCCCCCC	23.43	25168779
18	Phosphorylation	RDSPDRRSGSPDVKG CCCCCCCCCCCCCCC	44.51	26160508
20	Phosphorylation	SPDRRSGSPDVKGPP CCCCCCCCCCCCCCC	21.12	27899381
39	Phosphorylation	ARLEQNGSPMGARGR EEEECCCCCCCCCCC	21.18	23527152
376	Phosphorylation	RDELKRASVSQAVFA HHHHHHCCHHHHHHH	26.74	23140645
440	Phosphorylation	YQDERERSMNPNVSM HHHHHHHHCCCCCCC	20.40	23527152
452	Phosphorylation	VSMVSSASSSPSSSR CCCCCCCCCCCCCCC	33.04	24719451
454	Phosphorylation	MVSSASSSPSSSRTP CCCCCCCCCCCCCCC	26.72	25521595
467	Phosphorylation	TPQAKTSTPTTDLPI CCCCCCCCCCCCCCE	29.86	-
528	Phosphorylation	LRWKENPSPENRTLW HHCCCCCCCCCCHHH	57.33	21659604
587	Phosphorylation	QVLHRQQSQPTKESS HHHHCCCCCCCCCCC	29.77	19060867
593	Phosphorylation	QSQPTKESSPPREEA CCCCCCCCCCCCCCC	50.10	25521595
594	Phosphorylation	SQPTKESSPPREEAP CCCCCCCCCCCCCCC	39.76	25521595
607	Phosphorylation	APPPPPPTEDSCAKK CCCCCCCCCCCCCCC	59.19	25777480
610	Phosphorylation	PPPPTEDSCAKKPRS CCCCCCCCCCCCCCC	15.11	25777480
698	Phosphorylation	DEELLTESEENDSEE CHHHHCCCCCCCCCC	45.00	-
707	Phosphorylation	ENDSEEGSEEMYKVE CCCCCCCCHHHHHHH	33.39	-
711	Phosphorylation	EEGSEEMYKVEAEEE CCCCHHHHHHHHHHH	18.37	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SATB2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SATB2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SATB2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATF4_MOUSE	Atf4	physical	16751105
RUNX2_MOUSE	Runx2	physical	16751105

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.