UBQL4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBQL4_MOUSE
• UniProt AC: Q99NB8
• Protein Name: Ubiquilin-4
• Gene Name: Ubqln4
• Organism: Mus musculus (Mouse).
• Sequence Length: 596
• Subcellular Localization: Nucleus . Cytoplasm . Endoplasmic reticulum . Cytoplasm, perinuclear region . Cytoplasmic vesicle, autophagosome . Colocalizes with the proteasome, both in nucleus and cytoplasm (By similarity).
• Protein Description: Plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (By similarity). Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1. [PubMed: 18079109]
• Protein Sequence: MAEPSGAETRPQIRVTVKTPKDKEEIVICDQASVKEFKEEISRRFKAQQDQLVLIFAGKILKDGDTLSQHGIKDGLTVHLVIKTPQKAQDPVTAAASPPSTPDSASAPSTTPASPAAAPVQPCSSGNTTSDAGSGGGPSPVAAEGPSSATASILSGFGGILGLGSLGLGSANFMELQQQMQRQLMSNPEMLSQIMENPLVQDMMSNPDLMRHMIMANPQMQQLMERNPEISHMLNNPELMRQTMELARNPAMMQEMMRNQDRALSNLESVPGGYNALRRMYTDIQEPMFTAAREQFGNNPFSSLAGNSDNSSSQPLRTENREPLPNPWSPSPPTSQAPGSGGEGTGGSGTSQVHPTVSNPFGINAASLGSGMFNSPEMQALLQQISENPQLMQNVISAPYMRTMMQTLAQNPDFAAQMMVNVPLFAGNPQLQEQLRLQLPVFLQQMQNPESLSILTNPRAMQALLQIQQGLQTLQTEAPGLVPSLGSFGTPRTSVPLAGSNSGSSAEAPTSSPGVPATSPPSAGSNAQQQLMQQMIQLLSGSGNSQVPMPEVRFQQQLEQLNSMGFINREANLQALIATGGDINAAIERLLGSQLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Ubiquitination	EEISRRFKAQQDQLV HHHHHHHHHHHHHEE	43.40	22790023
59	Ubiquitination	LVLIFAGKILKDGDT EEEEEECEECCCCCC	41.24	-
139	Phosphorylation	AGSGGGPSPVAAEGP CCCCCCCCCCCCCCC	34.97	-
231	Phosphorylation	MERNPEISHMLNNPE HHHCHHHHHHHCCHH	10.94	22871156
274	Phosphorylation	LESVPGGYNALRRMY HHHCCCHHHHHHHHH	11.81	28059163
282	Phosphorylation	NALRRMYTDIQEPMF HHHHHHHHHCCCCHH	19.79	-
313	Phosphorylation	GNSDNSSSQPLRTEN CCCCCCCCCCCCCCC	35.32	-
494	Phosphorylation	SFGTPRTSVPLAGSN CCCCCCCCCCCCCCC	24.02	23649490

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBQL4_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
48	K	ubiquitylation	May undergo both 'Lys-48'- and 'Lys-63'-linked polyubiquitination.	-
313	S	Phosphorylation	Phosphorylated by ATM at Ser-313 in response to DNA damage, leading to localization in the nucleus and recruitment to sites of DNA damage.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBQL4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of UBQL4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.