dbPTM

DEF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DEF1_HUMAN
UniProt AC	P59665
Protein Name	Neutrophil defensin 1
Gene Name	DEFA1
Organism	Homo sapiens (Human).
Sequence Length	94
Subcellular Localization	Secreted.
Protein Description	Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane..
Protein Sequence	MRTLAILAAILLVALQAQAEPLQARADEVAAAPEQIAADIPEVVVSLAWDESLAPKHPGSRKNMACYCRIPACIAGERRYGTCIYQGRLWAFCC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
67	Phosphorylation	SRKNMACYCRIPACI CCCCCEEEEECCCHH	3.84	21253578
78	ADP-ribosylation	PACIAGERRYGTCIY CCHHCCCCCCEEEEE	35.88	-
78	ADP-ribosylation	PACIAGERRYGTCIY CCHHCCCCCCEEEEE	35.88	21904558
80	Phosphorylation	CIAGERRYGTCIYQG HHCCCCCCEEEEEEC	24.02	21253578
82	Phosphorylation	AGERRYGTCIYQGRL CCCCCCEEEEEECEE	6.18	28442448
83	S-nitrosylation	GERRYGTCIYQGRLW CCCCCEEEEEECEEE	2.07	25040305
85	Phosphorylation	RRYGTCIYQGRLWAF CCCEEEEEECEEEEE	13.68	21904558
88	ADP-ribosylation	GTCIYQGRLWAFCC- EEEEEECEEEEEEC-	16.13	-
88	ADP-ribosylation	GTCIYQGRLWAFCC- EEEEEECEEEEEEC-	16.13	21904558

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DEF1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DEF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DEF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IBP2_HUMAN	IGFBP2	physical	28514442
PP2BC_HUMAN	PPP3CC	physical	28514442
TKFC_HUMAN	DAK	physical	28514442
DIAC_HUMAN	CTBS	physical	28514442
CANB1_HUMAN	PPP3R1	physical	28514442
LIFR_HUMAN	LIFR	physical	28514442
SUSD1_HUMAN	SUSD1	physical	28514442
CATF_HUMAN	CTSF	physical	28514442
PP2BA_HUMAN	PPP3CA	physical	28514442
ARSB_HUMAN	ARSB	physical	28514442
FBLN1_HUMAN	FBLN1	physical	28514442
PXDN_HUMAN	PXDN	physical	28514442
TMEM2_HUMAN	TMEM2	physical	28514442
PP2BB_HUMAN	PPP3CB	physical	28514442
MCMBP_HUMAN	MCMBP	physical	28514442
SMOC1_HUMAN	SMOC1	physical	28514442
SULF2_HUMAN	SULF2	physical	28514442
CNTP3_HUMAN	CNTNAP3	physical	28514442
COEA1_HUMAN	COL14A1	physical	28514442
LOXL2_HUMAN	LOXL2	physical	28514442
PLXB2_HUMAN	PLXNB2	physical	28514442
NID2_HUMAN	NID2	physical	28514442
CA2D1_HUMAN	CACNA2D1	physical	28514442
PLXA2_HUMAN	PLXNA2	physical	28514442
CHLE_HUMAN	BCHE	physical	28514442
PADC1_HUMAN	PRADC1	physical	28514442
COIA1_HUMAN	COL18A1	physical	28514442
LAMA3_HUMAN	LAMA3	physical	28514442
CILP2_HUMAN	CILP2	physical	28514442
IGSF3_HUMAN	IGSF3	physical	28514442
EF2_HUMAN	EEF2	physical	28514442
GRN_HUMAN	GRN	physical	28514442
AB17B_HUMAN	ABHD17B	physical	28514442
EDEM3_HUMAN	EDEM3	physical	28514442
ZO1_HUMAN	TJP1	physical	28514442
LAMA5_HUMAN	LAMA5	physical	28514442
UBE3D_HUMAN	UBE3D	physical	28514442
LAMB1_HUMAN	LAMB1	physical	28514442
T132A_HUMAN	TMEM132A	physical	28514442
LAMB2_HUMAN	LAMB2	physical	28514442
MKS3_HUMAN	TMEM67	physical	28514442
MANBA_HUMAN	MANBA	physical	28514442
TGFB1_HUMAN	TGFB1	physical	28514442
CA2D2_HUMAN	CACNA2D2	physical	28514442
COCH_HUMAN	COCH	physical	28514442
NPC2_HUMAN	NPC2	physical	28514442
NOTC3_HUMAN	NOTCH3	physical	28514442
ARSK_HUMAN	ARSK	physical	28514442
ACHA5_HUMAN	CHRNA5	physical	28514442
LRP12_HUMAN	LRP12	physical	28514442
ITAV_HUMAN	ITGAV	physical	28514442
ITA7_HUMAN	ITGA7	physical	28514442
CNPY3_HUMAN	CNPY3	physical	28514442
TM131_HUMAN	TMEM131	physical	28514442
PLXA1_HUMAN	PLXNA1	physical	28514442
BMP1_HUMAN	BMP1	physical	28514442
EGFR_HUMAN	EGFR	physical	28514442
NPTX1_HUMAN	NPTX1	physical	28514442
CO6A1_HUMAN	COL6A1	physical	28514442
LDLR_HUMAN	LDLR	physical	28514442
CBPD_HUMAN	CPD	physical	28514442
SCRB1_HUMAN	SCARB1	physical	28514442
SLIT2_HUMAN	SLIT2	physical	28514442
GALNS_HUMAN	GALNS	physical	28514442
MICA_HUMAN	MICA	physical	28514442
LGMN_HUMAN	LGMN	physical	28514442
TTC17_HUMAN	TTC17	physical	28514442
WNT5A_HUMAN	WNT5A	physical	28514442
MOXD1_HUMAN	MOXD1	physical	28514442
CATL2_HUMAN	CTSV	physical	28514442
LRFN3_HUMAN	LRFN3	physical	28514442
TGBR3_HUMAN	TGFBR3	physical	28514442
FSTL1_HUMAN	FSTL1	physical	28514442
NRP2_HUMAN	NRP2	physical	28514442
H6ST1_HUMAN	HS6ST1	physical	28514442
ERAP1_HUMAN	ERAP1	physical	28514442
TIMP3_HUMAN	TIMP3	physical	28514442
MA2A2_HUMAN	MAN2A2	physical	28514442
NXPH4_HUMAN	NXPH4	physical	28514442
TPA_HUMAN	PLAT	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DEF1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Structural and functional consequences induced by post-translationalmodifications in alpha-Defensins."; Balducci E., Bonucci A., Picchianti M., Pogni R., Talluri E.; Int. J. Pept. 2011:594723-594723(2011). Cited for: ADP-RIBOSYLATION AT ARG-78 AND ARG-88 BY ART1, AND PHOSPHORYLATION ATTYR-85.	21904558 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-85, AND MASSSPECTROMETRY.	18083107 [Abstract]