CC50B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CC50B_HUMAN
• UniProt AC: Q3MIR4
• Protein Name: Cell cycle control protein 50B
• Gene Name: TMEM30B
• Organism: Homo sapiens (Human).
• Sequence Length: 351
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to the plasma membrane..
• Protein Sequence: MTWSATARGAHQPDNTAFTQQRLPAWQPLLSASIALPLFFCAGLAFIGLGLGLYYSSNGIKELEYDYTGDPGTGNCSVCAAAGQGRALPPPCSCAWYFSLPELFQGPVYLYYELTNFYQNNRRYGVSRDDAQLSGLPSALRHPVNECAPYQRSAAGLPIAPCGAIANSLFNDSFSLWHQRQPGGPYVEVPLDRSGIAWWTDYHVKFRNPPLVNGSLALAFQGTAPPPNWRRPVYELSPDPNNTGFINQDFVVWMRTAALPTFRKLYARIRQGNYSAGLPRGAYRVNITYNYPVRAFGGHKLLIFSSISWMGGKNPFLGIAYLVVGSLCILTGFVMLVVYIRYQDQDDDDEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTWSATARG ------CCCCCCCCC	28.29	-
4	Phosphorylation	----MTWSATARGAH ----CCCCCCCCCCC	13.43	-
6	Phosphorylation	--MTWSATARGAHQP --CCCCCCCCCCCCC	16.04	-
75	N-linked_Glycosylation	TGDPGTGNCSVCAAA CCCCCCCCCCEEECC	18.09	UniProtKB CARBOHYD
213	N-linked_Glycosylation	FRNPPLVNGSLALAF ECCCCCCCCEEEEEE	41.86	UniProtKB CARBOHYD
286	N-linked_Glycosylation	PRGAYRVNITYNYPV CCCCEEEEEEEECCC	16.34	UniProtKB CARBOHYD
291	Phosphorylation	RVNITYNYPVRAFGG EEEEEEECCCEEECC	7.84	-
305	Phosphorylation	GHKLLIFSSISWMGG CEEEEEEEECCCCCC	21.55	28348404
306	Phosphorylation	HKLLIFSSISWMGGK EEEEEEEECCCCCCC	15.19	28348404
308	Phosphorylation	LLIFSSISWMGGKNP EEEEEECCCCCCCCC	16.98	28348404
321	Phosphorylation	NPFLGIAYLVVGSLC CCCHHHHHHHHHHHH	9.71	25332170
339	Phosphorylation	GFVMLVVYIRYQDQD HHEEEEEEEECCCCC	3.38	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CC50B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CC50B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CC50B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCD17_HUMAN	PCDH17	physical	28514442
PRTG_HUMAN	PRTG	physical	28514442
SGCE_HUMAN	SGCE	physical	28514442
IGDC4_HUMAN	IGDCC4	physical	28514442
PCDGB_HUMAN	PCDHGA11	physical	28514442
TYRO3_HUMAN	TYRO3	physical	28514442
FGFR4_HUMAN	FGFR4	physical	28514442
TM230_HUMAN	TMEM230	physical	28514442
FGFR2_HUMAN	FGFR2	physical	28514442
PDXL2_HUMAN	PODXL2	physical	28514442
PCDGL_HUMAN	PCDHGC4	physical	28514442
NECT2_HUMAN	PVRL2	physical	28514442
FGFR3_HUMAN	FGFR3	physical	28514442
MA1A1_HUMAN	MAN1A1	physical	28514442
SDK2_HUMAN	SDK2	physical	28514442
TTMP_HUMAN	C3orf52	physical	28514442
PLXA2_HUMAN	PLXNA2	physical	28514442
FUT8_HUMAN	FUT8	physical	28514442
PCDGK_HUMAN	PCDHGC3	physical	28514442
PCD10_HUMAN	PCDH10	physical	28514442
TM143_HUMAN	TMEM143	physical	28514442
NALD2_HUMAN	NAALAD2	physical	28514442
JAG2_HUMAN	JAG2	physical	28514442
KIRR1_HUMAN	KIRREL	physical	28514442
EPHA7_HUMAN	EPHA7	physical	28514442
CELR2_HUMAN	CELSR2	physical	28514442
OCLN_HUMAN	OCLN	physical	28514442
CDHR1_HUMAN	CDHR1	physical	28514442
CC50A_HUMAN	TMEM30A	physical	28514442
KLH15_HUMAN	KLHL15	physical	28514442
I27RA_HUMAN	IL27RA	physical	28514442
TNFL9_HUMAN	TNFSF9	physical	28514442
ULBP3_HUMAN	ULBP3	physical	28514442
AGRL1_HUMAN	LPHN1	physical	28514442
C1QRF_HUMAN	C1QL1	physical	28514442
ULBP2_HUMAN	ULBP2	physical	28514442
MPZL1_HUMAN	MPZL1	physical	28514442
SCRB1_HUMAN	SCARB1	physical	28514442
MFAP3_HUMAN	MFAP3	physical	28514442
LRFN1_HUMAN	LRFN1	physical	28514442
B4GT1_HUMAN	B4GALT1	physical	28514442
F1712_HUMAN	FAM171A2	physical	28514442
CAH12_HUMAN	CA12	physical	28514442
APBB2_HUMAN	APBB2	physical	28514442
PCDH7_HUMAN	PCDH7	physical	28514442
K319L_HUMAN	KIAA0319L	physical	28514442
TSN3_HUMAN	TSPAN3	physical	28514442
IGSF8_HUMAN	IGSF8	physical	28514442
FCGRN_HUMAN	FCGRT	physical	28514442
STX4_HUMAN	STX4	physical	28514442
TSN6_HUMAN	TSPAN6	physical	28514442
SIDT2_HUMAN	SIDT2	physical	28514442
A4_HUMAN	APP	physical	28514442
DSC2_HUMAN	DSC2	physical	28514442
TIP_HUMAN	ITFG1	physical	28514442
FGFR1_HUMAN	FGFR1	physical	28514442
GOT1B_HUMAN	GOLT1B	physical	28514442
KLRG2_HUMAN	KLRG2	physical	28514442
C1QL4_HUMAN	C1QL4	physical	28514442
CELR3_HUMAN	CELSR3	physical	28514442
LRC8A_HUMAN	LRRC8A	physical	28514442
DSC3_HUMAN	DSC3	physical	28514442
PTPRF_HUMAN	PTPRF	physical	28514442
MKS3_HUMAN	TMEM67	physical	28514442
ACV1B_HUMAN	ACVR1B	physical	28514442
CD276_HUMAN	CD276	physical	28514442
INGR1_HUMAN	IFNGR1	physical	28514442
GPC5C_HUMAN	GPRC5C	physical	28514442
SEM4F_HUMAN	SEMA4F	physical	28514442
NETO2_HUMAN	NETO2	physical	28514442
MA1A2_HUMAN	MAN1A2	physical	28514442
MANEA_HUMAN	MANEA	physical	28514442
NGBR_HUMAN	NUS1	physical	28514442
SEM4C_HUMAN	SEMA4C	physical	28514442
PTPRS_HUMAN	PTPRS	physical	28514442
GP1BB_HUMAN	GP1BB	physical	28514442
STXB3_HUMAN	STXBP3	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.